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系統識別號 U0026-3001201804425400
論文名稱(中文) 應用最佳化方法於軟組織切片針之幾何形狀與切削參數之研究
論文名稱(英文) Optimizing Geometric and Cutting Parameters of Biopsy Needle
校院名稱 成功大學
系所名稱(中) 機械工程學系
系所名稱(英) Department of Mechanical Engineering
學年度 106
學期 1
出版年 106
研究生(中文) 鄭育宸
研究生(英文) Yu-Chen Jheng
學號 N16041391
學位類別 碩士
語文別 中文
論文頁數 71頁
口試委員 指導教授-林啟倫
口試委員-藍兆杰
口試委員-陳家豪
中文關鍵字 穿刺法  旋轉切削法  針頭組織切片  切削力 
英文關鍵字 insertion cutting method  rotational cutting method  needle biopsy  cutting force 
學科別分類
中文摘要 組織切片技術已被廣為應用於醫療領域中,其切片針頭在切削過程中的切削力為影響取出樣本品質之重要因素,降低切削力有助於獲取較完整之樣本,進而提升診斷之準確率。為了解切削時針頭形狀與其參數配置對切削行為之影響,本研究應用最佳化方法於針頭之幾何參數以及切削參數以最小化切削力,並進一步探討各參數之效應。
現今之乳癌切片技術主要可分為兩類:穿刺法與旋轉切削法,本研究使用人工軟組織吉利丁模擬乳房組織,運用田口品質設計方法於柳葉針、後斜面針兩種穿刺針之幾何形狀中,透過計算針頭之傾角預測切削力之大小,並由信號雜音比獲取之最佳幾何參數組合交互比對,此外亦輸出變異數分析表探討其對切削力之影響程度;在旋轉針的部分,本文使用了反應曲面法尋找其最佳切削參數組合,透過一階模型的擬合與逐步的搜尋程序,獲取最佳之軸向速度與轉速比配置,並進一部由確認實驗驗證結果之準確度。研究結果顯示利用穿刺針傾角所預測之最佳幾何形狀與田口方法之結果相互驗證;而旋轉針之最佳參數配置與確認實驗也僅有1.82%之誤差。
英文摘要 The needle biopsy technology has been widely applied to many medical fields. In the biopsy procedure, the tissue cutting force is a key factor which affects the quality of obtained samples. The quality of tissue samples can be improved with a reduced cutting force, which leads to more accurate cancer diagnosis. To study the influence of needle geometry and parameter configuration to the cutting force, this research applies design optimization methodologies to find optimal geometric and cutting parameters of the biopsy needles that minimize the cutting force. The effect of each parameter is also investigated.
Two main needle cutting methods, stationary needle insertion and rotational cutting methods are concerned in this study. Gelatin tissue phantom is used to mimic the breast tissue. Taguchi method is applied to optimize the geometry of needles with lancet and back bevel tips. The relative magnitude of cutting force is predicted by solving inclination angle of these two types of needles, and the results are compared with optimal geometric configuration which produced the largest signal-to-noise ratio (SNR) in the Taguchi method. The ANOVA is also used to investigate the main effect of these geometric parameters. For the rotational needles, response surface methodology (RSM) is used to search optimal cutting parameters. From the response surface, the minimal cutting force is found when axial speed and slice-push ratio (SPR) are 2.01 mm/s and 4.66, respectively. As a result, this study provided optimal geometric parameters of two types of non-rotational needles and cutting parameters of rotational needles to minimize the tissue cutting force.
論文目次 摘要 I
Optimizing Geometric and Cutting Parameters of Biopsy Needle II
致謝 IX
目錄 X
表目錄 XIII
圖目錄 XIV
符號說明 XVI
第一章 緒論 1
1.1 研究背景 1
1.2 研究動機 2
1.3 文獻回顧 4
1.4 研究目的 8
1.5 本文架構 9
第二章 組織與穿刺針之製作 11
2.1 組織製作與性質量測 11
2.1.1 組織製作流程 11
2.1.2 壓痕試驗與驗證 12
2.2 實驗設備及針頭幾何形狀 15
2.2.1 穿刺針製作流程 15
2.2.2 穿刺針之傾角 17
第三章 穿刺針與旋轉針之實驗設計 25
3.1 田口品質設計方法 25
3.1.1 直交表 26
3.1.2 信號雜音比 27
3.1.3 變異數分析 28
3.2 反應曲面法 32
3.2.1 中心合成設計 34
3.2.2 一階模式與缺適性檢定 36
3.2.3 最陡坡度法 37
3.2.4 二階模式與平穩點 38
第四章 實驗結果分析與討論 40
4.1 組織性質與穿刺針幾何特性 40
4.1.1 組織性質與有限元素模型驗證 40
4.1.2 穿刺針之傾角 41
4.2 穿刺針之最佳幾何參數 45
4.2.1 幾何參數與特性對切削力之影響 46
4.2.2 柳葉針幾何參數分析 48
4.2.3 後斜面針幾何參數分析 50
4.3 旋轉針之最佳切削參數 53
4.3.1 一階反應曲面分析 54
4.3.2 最陡坡度法 56
4.3.3 二階反應曲面分析 59
4.4 切削實驗結果之討論 63
4.4.1 穿刺針切削之總結 63
4.4.2 旋轉針切削之總結 65
第五章 結論與建議 67
5.1 結論 67
5.2 未來研究方向 68
參考文獻 69

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