進階搜尋


   電子論文尚未授權公開,紙本請查館藏目錄
(※如查詢不到或館藏狀況顯示「閉架不公開」,表示該本論文不在書庫,無法取用。)
系統識別號 U0026-2507201217480400
論文名稱(中文) 探討cAMP次級傳遞因子如何調控人類血癌細胞株HEL的移動能力情況
論文名稱(英文) cAMP regulates human erythroleukemia cell mobility
校院名稱 成功大學
系所名稱(中) 藥理學研究所
系所名稱(英) Department of Pharmacology
學年度 100
學期 2
出版年 101
研究生(中文) 羅永臻
研究生(英文) Yong-Zhen Lo
學號 s26991128
學位類別 碩士
語文別 中文
論文頁數 68頁
口試委員 指導教授-簡偉明
口試委員-陳清玉
口試委員-錢偉鈞
中文關鍵字 細胞遷徙  侵潤  轉移  細胞遷移的可塑性  環腺苷酸單磷酸  佛波醇乙酸酯  HEL血癌細胞株  視頻時差顯微技術  雙極細胞  移動速率 
英文關鍵字 cell migration  invasion  metastasis  plasticity of cell migration  cAMP  PMA  human erythroleukemia (HEL) cells  time-lapse microscope  dipolar cells  migration rate 
學科別分類
中文摘要 細胞遷移是許多生物反應的基本過程,包括細胞的浸潤和轉移。但過去,細胞如何根據不同的刺激或環境變化修改其移動能力仍未被深入的探討。此種細胞適應環境的過程又可稱作細胞遷移的可塑性,其中涉及形態以及遷移速率的改變。這種可塑性例子的其中之一是藥物引起的可塑性,因此提共了藉由不同藥物處理的方式達到分析細胞遷移能力改變的研究方法與概念。例如,過去研究指出,不同的細胞內cAMP濃度會影響纖維母細胞,角質細胞以及嗜中性顆粒球的移動能力情形。然而此種因細胞內不同的cAMP濃度,對細胞移動能力所造成的影響仍然頗具爭議且似乎是依據細胞種類而有所不同。因此,為了探討cAMP在人類血癌細胞株HEL分化時的移動能力情形;此處,我們選用佛波指酸 (phorbol 12-myristate 13-acetate)作為誘導分化的致效劑,此藥物為PKC致效劑,並可誘導其下游訊息傳遞路徑而促進HEL細胞的分化,但不會誘導cAMP的產生,因此藉由對人類血癌細胞株HEL在有無forskolin前處理的情況下,接受PMA的刺激,進而獨立探討cAMP於其中的角色為何。此處我們使用,視頻時差顯微技術(time lapse microscopy)紀錄視野下HEL細胞的移動狀態,並發現在forskolin前處理的情況下,會改變PMA刺激後HEL細胞的移動模式。例如,PMA刺激之下,細胞型態會產生異質化的情況,並主要分為五類: 紡錘狀細胞,單極細胞,雙極細胞,盤狀或扇形細胞,以及圓狀且快速移動細胞。有趣的是,在前處理forskolin的HEL細胞,經由PMA刺激後,雙極細胞的比例與細胞的移動速率皆有明顯的增加。
英文摘要 Cell migration is fundamental processes of several biological responses including cell invasion and metastasis. But in the past, how cells modify their mobility upon different stimuli or environmental changes is still largely unexplored. These kinds of adaptive processes is refer to plasticity of cell migration which were involved changes of morphology and migration rate. One of this plasticity is drugs induced plasticity which allowed switching of cell migration can be analyzed by different drugs treatment. For instance, in previously finding, intracellular cAMP level can influence fibroblast, keratinocyte and neutrophil cell mobility; however, their effects on cell mobility is still controversial and seem to cell type dependent. Therefore, to determine what roles of cAMP participate in human erythroleukemia (HEL) cell mobility and what roles of cAMP can modify cell morphology and/or migration pattern of HEL cell during their course of differentiation; here, we chose phorbol 12-myristate 13-acetate (PMA) as a differentiation agent which is a PKC agonist and doesn't elicit intracellular cAMP elevation. As a result, HEL cell pretreated with or without forskolin provided the solitary role of cAMP to be analyzed. For cell migration analysis, we used time-lapse microscope to record dynamic mobility of human erythroleukemia (HEL) cells upon PMA stimulation, and found cells pre-treating forskolin can switch the pattern of PMA-stimulated HEL cells mobility during differentiation. That is, the morphology of PMA-stimulated HEL cells is heterogeneous and can be categorized into five types base on their morphology: spindle-like dipolar, uni-polar, dish and fan-shaped spreading and rounded fast moving cells, with remarkably different degree of ruffling membrane and migration rate. Intriguingly, forskolin (FSK)-pretreated HEL cells substantially increase in proportion of dipolar cell count and migration rate upon PMA stimulation.
論文目次 目錄
口試合格證明----------------------------------------------------I
摘要------------------------------------------------------------II
Abstract--------------------------------------------------------IV
致謝------------------------------------------------------------VI
目錄------------------------------------------------------------VII
圖表目錄--------------------------------------------------------VIII
縮寫表----------------------------------------------------------IX
緒論------------------------------------------------------------1
材料與方法------------------------------------------------------26
實驗結果--------------------------------------------------------32
討論------------------------------------------------------------34
參考文獻--------------------------------------------------------43
附錄------------------------------------------------------------61
參考文獻 參考文獻

Abercrombie, M., Dunn, G.A., and Heath, J.P. (1977). The shape and movement of fibroblasts in culture. Soc Gen Physiol Ser 32, 57-70.
Acloque, H., Adams, M.S., Fishwick, K., Bronner-Fraser, M., and Nieto, M.A. (2009). Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest 119, 1438-1449.
Adams, J.C. (2001). Cell-matrix contact structures. Cell Mol Life Sci 58, 371-392.
Apgar, J.R. (1991). Regulation of the antigen-induced F-actin response in rat basophilic leukemia cells by protein kinase C. J Cell Biol 112, 1157-1163.
Bach, P.B., and Schrag, D. (2002). Risk charts: putting cancer in context. J Natl Cancer Inst 94, 1584-1585; author reply 1585-1586.
Alvin M. Malkinson and Martin S. Butley. (1981). Alterations in cyclic adenosine 3':5'-monophosphate-dependent protein kinases during normal and neoplastic lung development. CANCER RESEARCH 41, 1334-1341.
Alvin M. Malkinson. (1985). Changes in cyclic adenosine 3':5'-monophosphate-dependent protein kinases during the progression of urethan-induced mouse lung tumors. CANCER RESEARCH 45, 3677-3685.
A. J. Shaywitz and M. E. Greenberg. (1999). “CREB: a stimulus induced transcription factor activated by a diverse array of extracellular signals,” Annual Review of Biochemistry, 68, 821–861.
Ally, S., Clair. T.. Katsaros. D.. Tortora, G.. Yokozaki, H.. Finch, R. A., Avery, T. L.. and Cho-Chung, Y. S. (1989). Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by siteselective 8-Cl-cyclic adenosine monophosphate. CANCER RESEARCH, 49, 5650-5655.
Ballestrem, C., Hinz, B., Imhof, B.A., and Wehrle-Haller, B. (2001). Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior. J Cell Biol 155, 1319-1332.
Barsoum, I.B., and King-Smith, C. (2007). Myosin II and Rho kinase activity are required for melanosome aggregation in fish retinal pigment epithelial cells. Cell Motil Cytoskeleton 64, 868-879.
Bear, J.E., Loureiro, J.J., Libova, I., Fassler, R., Wehland, J., and Gertler, F.B. (2000). Negative regulation of fibroblast motility by Ena/VASP proteins. Cell 101, 717-728.
Bear, J.E., Svitkina, T.M., Krause, M., Schafer, D.A., Loureiro, J.J., Strasser, G.A., Maly, I.V., Chaga, O.Y., Cooper, J.A., Borisy, G.G., et al. (2002). Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell 109, 509-521.
Bell, C.D., and Waizbard, E. (1986). Variability of cell size in primary and metastatic human breast carcinoma. Invasion Metastasis 6, 11-20.
Bhowmick, N.A., and Moses, H.L. (2005). Tumor-stroma interactions. Curr Opin Genet Dev 15, 97-101.
Birchmeier, C., Birchmeier, W., and Brand-Saberi, B. (1996). Epithelial-mesenchymal transitions in cancer progression. Acta Anat (Basel) 156, 217-226.
Bowden, E.T., Onikoyi, E., Slack, R., Myoui, A., Yoneda, T., Yamada, K.M., and Mueller, S.C. (2006). Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. Exp Cell Res 312, 1240-1253.
Brakebusch, C., Fillatreau, S., Potocnik, A.J., Bungartz, G., Wilhelm, P., Svensson, M., Kearney, P., Korner, H., Gray, D., and Fassler, R. (2002). Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Immunity 16, 465-477.
Bruserud, O., Ryningen, A., Wergeland, L., Glenjen, N.I., and Gjertsen, B.T. (2004). Osteoblasts increase proliferation and release of pro-angiogenic interleukin 8 by native human acute myelogenous leukemia blasts. Haematologica 89, 391-402.
Buensuceso, C.S., Obergfell, A., Soriani, A., Eto, K., Kiosses, W.B., Arias-Salgado, E.G., Kawakami, T., and Shattil, S.J. (2005). Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta. J Biol Chem 280, 644-653.
Byers, S.W., Sommers, C.L., Hoxter, B., Mercurio, A.M., and Tozeren, A. (1995). Role of E-cadherin in the response of tumor cell aggregates to lymphatic, venous and arterial flow: measurement of cell-cell adhesion strength. J Cell Sci 108 ( Pt 5), 2053-2064.
Bowden, E.T., Barth, M., Thomas, D., Glazer, R.I., and Mueller, S.C. (1999). An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation. Oncogene 18, 4440-4449.
Burridge, K., and Connell, L. (1983). A new protein of adhesion plaques and ruffling membranes. The Journal of cell biology 97, 359-367.
Campbell, M., and Trimble, E.R. (2005). Modification of PI3K- and MAPK-dependent chemotaxis in aortic vascular smooth muscle cells by protein kinase CbetaII. Circ Res 96, 197-206.
Cardone, R.A., Bellizzi, A., Busco, G., Weinman, E.J., Dell'Aquila, M.E., Casavola, V., Azzariti, A., Mangia, A., Paradiso, A., and Reshkin, S.J. (2007). The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells. Mol Biol Cell 18, 1768-1780.
Carmeliet, P., and Jain, R.K. (2000). Angiogenesis in cancer and other diseases. Nature 407, 249-257.
Carnevale, K.A., and Cathcart, M.K. (2003). Protein kinase C beta is required for human monocyte chemotaxis to MCP-1. J Biol Chem 278, 25317-25322.
Carroll, R.C., Butler, R.G., Morris, P.A., and Gerrard, J.M. (1982). Separable assembly of platelet pseudopodal and contractile cytoskeletons. Cell 30, 385-393.
Chaffer, C.L., Thompson, E.W., and Williams, E.D. (2007). Mesenchymal to epithelial transition in development and disease. Cells Tissues Organs 185, 7-19.
Chao, C., Lotz, M.M., Clarke, A.C., and Mercurio, A.M. (1996). A function for the integrin alpha6beta4 in the invasive properties of colorectal carcinoma cells. Cancer Res 56, 4811-4819.
Choi, J.H., Choi, K.C., Auersperg, N., and Leung, P.C. (2006). Gonadotropins activate proteolysis and increase invasion through protein kinase A and phosphatidylinositol 3-kinase pathways in human epithelial ovarian cancer cells. Cancer Res 66, 3912-3920.
Christian, F., Szaszak, M., Friedl, S., Drewianka, S., Lorenz, D., Goncalves, A., Furkert, J., Vargas, C., Schmieder, P., Gotz, F., et al. (2011). Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. J Biol Chem 286, 9079-9096.
Critchley, D.R., and Gingras, A.R. (2008). Talin at a glance. J Cell Sci 121, 1345-1347.
Collen, A., Hanemaaijer, R., Lupu, F., Quax, P.H., van Lent, N., Grimbergen, J., Peters, E., Koolwijk, P., and van Hinsbergh, V.W. (2003). Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix. Blood 101, 1810-1817.
Condeelis, J., Jones, J., and Segall, J.E. (1992). Chemotaxis of metastatic tumor cells: clues to mechanisms from the Dictyostelium paradigm. Cancer Metastasis Rev 11, 55-68.
Coussens, L.M., Fingleton, B., and Matrisian, L.M. (2002). Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 295, 2387-2392.
Cress, A.E., Rabinovitz, I., Zhu, W., and Nagle, R.B. (1995). The alpha 6 beta 1 and alpha 6 beta 4 integrins in human prostate cancer progression. Cancer Metastasis Rev 14, 219-228.
Christian Rohlff, Timothy Clair, and Yoon S. Cho-Chung. (1993). 8-Cl-CAMP Induces Truncation and down-regulation of the RI, Subunit and Up-regulation of the RIIB Subunit of cAMP-dependent Protein Kinase Leading to Type II Holoenzyme-dependent Growth Inhibition and Differentiation of HL-60 Leukemia Cells. THE JOURNA L OF BIOLOGICAL CHEMISTRY, 268, 5774-5782.
d'Ortho, M.P., Stanton, H., Butler, M., Atkinson, S.J., Murphy, G., and Hembry, R.M. (1998). MT1-MMP on the cell surface causes focal degradation of gelatin films. FEBS Lett 421, 159-164.
Chris C. Carlson., Stacy L. Smithers., Karen A. Yeh., Laura L. Burnham and Daniel T. Dransfield. (1999). Protein kinase A regulatory subunit in colon cancer. Neoplasia 1, 373-378.
Christian Rohlff, Timothy Clair, and Yoon S. Cho-Chung. (1993). 8-Cl-CAMP Induces Truncation and down-regulation of the RI, Subunit and Up-regulation of the RIIB Subunit of cAMP-dependent Protein Kinase Leading to Type II Holoenzyme-dependent Growth Inhibition and Differentiation of HL-60 Leukemia Cells. THE JOURNA L OF BIOLOGICAL CHEMISTRY, 268, 5774-5782.
Cho-Chung, Y. S. (1989). Commentary: site-selective 8-chloro-cyclic adenosine 3',5'-monophosphate as a biologic modulator of cancer: restoration of normal control mechanisms. J. Nati. Cancer Inst, 81, 982-987.
Cho-Chung, Y. S., Clair, T., and Shepheard. C. (1983). Anticarcinogenic effect of N6,O2' -dibutyryl cyclic adenosine 3':5'-monophosphate on 7,12-dimethylbenz(a)anthracene mammary tumor induction in the rat and its relationship to cyclic adenosine 3':5'-monophosphate metabolism and protein kinase. CANCER RESEARCH, 43, 2736-2740.
Clair T, Ally S, Tagliaferri P, Robins RK, Cho-Chung YS. (1987). Site-selective cAMP analogs indue nuclear translocation of the RII cAMP receptor protein in Ha-MuSV-transformed NIH/3T3 cells. FEBS Letters, 30, 377-384.
Dabizzi, S., Noci, I., Borri, P., Borrani, E., Giachi, M., Balzi, M., Taddei, G.L., Marchionni, M., Scarselli, G.F., and Arcangeli, A. (2003). Luteinizing hormone increases human endometrial cancer cells invasiveness through activation of protein kinase A. Cancer Res 63, 4281-4286.
Danen, E.H., van Kraats, A.A., Cornelissen, I.M., Ruiter, D.J., and van Muijen, G.N. (1996). Integrin beta 3 cDNA transfection into a highly metastatic alpha v beta 3-negative human melanoma cell line inhibits invasion and experimental metastasis. Biochem Biophys Res Commun 226, 75-81.
Danen, E.H., van Muijen, G.N., van de Wiel-van Kemenade, E., Jansen, K.F., Ruiter, D.J., and Figdor, C.G. (1993). Regulation of integrin-mediated adhesion to laminin and collagen in human melanocytes and in non-metastatic and highly metastatic human melanoma cells. Int J Cancer 54, 315-321.
Dartsch, P.C., Ritter, M., Haussinger, D., and Lang, F. (1994). Cytoskeletal reorganization in NIH 3T3 fibroblasts expressing the ras oncogene. Eur J Cell Biol 63, 316-325.
Davidson, L.A., and Keller, R.E. (1999). Neural tube closure in Xenopus laevis involves medial migration, directed protrusive activity, cell intercalation and convergent extension. Development 126, 4547-4556.
Della Porta, P., Soeltl, R., Krell, H.W., Collins, K., O'Donoghue, M., Schmitt, M., and Kruger, A. (1999). Combined treatment with serine protease inhibitor aprotinin and matrix metalloproteinase inhibitor Batimastat (BB-94) does not prevent invasion of human esophageal and ovarian carcinoma cells in vivo. Anticancer Res 19, 3809-3816.
Diviani, D., and Scott, J.D. (2001). AKAP signaling complexes at the cytoskeleton. J Cell Sci 114, 1431-1437.
Dodge-Kafka, K.L., Soughayer, J., Pare, G.C., Carlisle Michel, J.J., Langeberg, L.K., Kapiloff, M.S., and Scott, J.D. (2005). The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature 437, 574-578.
Dorman, G., Cseh, S., Hajdu, I., Barna, L., Konya, D., Kupai, K., Kovacs, L., and Ferdinandy, P. (2010). Matrix metalloproteinase inhibitors: a critical appraisal of design principles and proposed therapeutic utility. Drugs 70, 949-964.
Downey, G.P., Chan, C.K., Lea, P., Takai, A., and Grinstein, S. (1992). Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C. J Cell Biol 116, 695-706.
Dunlap, M.K. (1980). Cyclic AMP levels in migrating and non-migrating newt epidermal cells. J Cell Physiol 104, 367-373.
El Fahime, E., Torrente, Y., Caron, N.J., Bresolin, M.D., and Tremblay, J.P. (2000). In vivo migration of transplanted myoblasts requires matrix metalloproteinase activity. Exp Cell Res 258, 279-287.
Elferink, J.G., and de Koster, B.M. (1997). The stimulation of human neutrophil migration by angiotensin IL: its dependence on Ca2+ and the involvement of cyclic GMP. Br J Pharmacol 121, 643-648.
Eliasson, L., Ma, X., Renstrom, E., Barg, S., Berggren, P.O., Galvanovskis, J., Gromada, J., Jing, X., Lundquist, I., Salehi, A., et al. (2003). SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells. J Gen Physiol 121, 181-197.
Falcioni, R., Cimino, L., Gentileschi, M.P., D'Agnano, I., Zupi, G., Kennel, S.J., and Sacchi, A. (1994). Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human lung carcinoma cells of different histotypes. Exp Cell Res 210, 113-122.
Farina, K.L., Wyckoff, J.B., Rivera, J., Lee, H., Segall, J.E., Condeelis, J.S., and Jones, J.G. (1998). Cell motility of tumor cells visualized in living intact primary tumors using green fluorescent protein. Cancer Res 58, 2528-2532.
Fassler, R., and Meyer, M. (1995). Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev 9, 1896-1908.
Fassler, R., Pfaff, M., Murphy, J., Noegel, A.A., Johansson, S., Timpl, R., and Albrecht, R. (1995). Lack of beta 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts. J Cell Biol 128, 979-988.
Fernandez, M.I., Heuze, M.L., Martinez-Cingolani, C., Volpe, E., Donnadieu, M.H., Piel, M., Homey, B., Lennon-Dumenil, A.M., and Soumelis, V. (2011). The human cytokine TSLP triggers a cell-autonomous dendritic cell migration in confined environments. Blood 118, 3862-3869.
French, A.D., Fiori, J.L., Camilli, T.C., Leotlela, P.D., O'Connell, M.P., Frank, B.P., Subaran, S., Indig, F.E., Taub, D.D., and Weeraratna, A.T. (2009). PKC and PKA phosphorylation affect the subcellular localization of claudin-1 in melanoma cells. Int J Med Sci 6, 93-101.
Friedl, P. (2004). Prespecification and plasticity: shifting mechanisms of cell migration. Curr Opin Cell Biol 16, 14-23.
Friedl, P., Borgmann, S., and Brocker, E.B. (2001). Amoeboid leukocyte crawling through extracellular matrix: lessons from the Dictyostelium paradigm of cell movement. J Leukoc Biol 70, 491-509.
Friedl, P., and Brocker, E.B. (2000). The biology of cell locomotion within three-dimensional extracellular matrix. Cell Mol Life Sci 57, 41-64.
Friedl, P., Noble, P.B., Walton, P.A., Laird, D.W., Chauvin, P.J., Tabah, R.J., Black, M., and Zanker, K.S. (1995). Migration of coordinated cell clusters in mesenchymal and epithelial cancer explants in vitro. Cancer Res 55, 4557-4560.
Friedl, P., Zanker, K.S., and Brocker, E.B. (1998). Cell migration strategies in 3-D extracellular matrix: differences in morphology, cell matrix interactions, and integrin function. Microsc Res Tech 43, 369-378.
Fukuyama, T., Sueoka, E., Sugio, Y., Otsuka, T., Niho, Y., Akagi, K., and Kozu, T. (2001). MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes. Oncogene 20, 6225-6232.
Fumiaki Nakajima, Shinsaku Imashuku, Judith Wilimas, John E. Champion, and Alexander A. Green. (1984). Distribution and Properties of Type I and Type II Binding Proteins in the Cyclic Adenosine 3':5'-Monophosphate-dependent Protein Kinase System in Wilms' Tumor. CANCER RESEARCH 44,5182-5187.
Gallagher, S.J., Rambow, F., Kumasaka, M., Champeval, D., Bellacosa, A., Delmas, V., and Larue, L. (2012). Beta-catenin inhibits melanocyte migration but induces melanoma metastasis. Oncogene.
Giese, A., Laube, B., Zapf, S., Mangold, U., and Westphal, M. (1998). Glioma cell adhesion and migration on human brain sections. Anticancer Res 18, 2435-2447.
Goyal, A., Martin, T.A., Mansel, R.E., and Jiang, W.G. (2008). Real time PCR analyses of expression of E-cadherin, alpha-, beta- and gamma-catenin in human breast cancer for predicting clinical outcome. World J Surg Oncol 6, 56.
Gruber, R., Kandler, B., Holzmann, P., Vogele-Kadletz, M., Losert, U., Fischer, M.B., and Watzek, G. (2005). Bone marrow stromal cells can provide a local environment that favors migration and formation of tubular structures of endothelial cells. Tissue engineering 11, 896-903.
Gupta, S.K., Oommen, S., Aubry, M.C., Williams, B.P., and Vlahakis, N.E. (2012). Integrin alpha9beta1 promotes malignant tumor growth and metastasis by potentiating epithelial-mesenchymal transition. Oncogene.
Harrington, E.O., Loffler, J., Nelson, P.R., Kent, K.C., Simons, M., and Ware, J.A. (1997). Enhancement of migration by protein kinase Calpha and inhibition of proliferation and cell cycle progression by protein kinase Cdelta in capillary endothelial cells. J Biol Chem 272, 7390-7397.
Giampaolo Tortora, Timothy Clair, Dionyssios Katsaros, Shamsia Ally, Oscar Colamonici, Leonard M. Neckers, Pierosandro Tagliaferri, Tore Jahnsen, Roland K. Robins, and Yoon Sang Cho-Chung. (1989). Induction of megakaryocytic differentiation and modulation of protein kinase gene expression by site-selective cAMP analogs in K-562 human leukemic cells. Proc. Nati. Acad. Sci. USA, 86, 2849-2852.
Giampaolo Tortora, Stefano Pepe, Anna Maria Cirafici, Fortunato Ciardiello,Antonio Porcellini, Tim Clair, Giulia Colletta, Yoon Sang Cho-Chung, and A. Raffaele Bianco. (1993). Thyroid-stimulating Hormone-regulated Growth and Cell Cycle Distribution of Thyroid Cells Involve Type I Isozyme of Cyclic AMP-dependent Protein Kinase. Cell Growth & Differentiation, 4, 359-365.
Hashizume, R., Koizumi, H., Ihara, A., Ohta, T., and Uchikoshi, T. (1996). Expression of beta-catenin in normal breast tissue and breast carcinoma: a comparative study with epithelial cadherin and alpha-catenin. Histopathology 29, 139-146.
Hatfield, K., Ryningen, A., Corbascio, M., and Bruserud, O. (2006). Microvascular endothelial cells increase proliferation and inhibit apoptosis of native human acute myelogenous leukemia blasts. International journal of cancer Journal international du cancer 119, 2313-2321.
He, Y., and Grinnell, F. (1994). Stress relaxation of fibroblasts activates a cyclic AMP signaling pathway. J Cell Biol 126, 457-464.
Hegerfeldt, Y., Tusch, M., Brocker, E.B., and Friedl, P. (2002). Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies. Cancer Res 62, 2125-2130.
Holz, G.G., Kang, G., Harbeck, M., Roe, M.W., and Chepurny, O.G. (2006). Cell physiology of cAMP sensor Epac. J Physiol 577, 5-15.
Honczarenko, M., Le, Y., Swierkowski, M., Ghiran, I., Glodek, A.M., and Silberstein, L.E. (2006). Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem cells (Dayton, Ohio) 24, 1030-1041.
Howe, A.K., Baldor, L.C., and Hogan, B.P. (2005). Spatial regulation of the cAMP-dependent protein kinase during chemotactic cell migration. Proc Natl Acad Sci U S A 102, 14320-14325.
Itoh, K., Yoshioka, K., Akedo, H., Uehata, M., Ishizaki, T., and Narumiya, S. (1999). An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat Med 5, 221-225.
Iwabu, A., Smith, K., Allen, F.D., Lauffenburger, D.A., and Wells, A. (2004). Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway. J Biol Chem 279, 14551-14560.
Iwasaki, T., Chen, J.D., Kim, J.P., Wynn, K.C., and Woodley, D.T. (1994). Dibutyryl cyclic AMP modulates keratinocyte migration without alteration of integrin expression. J Invest Dermatol 102, 891-897.
Jacques, T.S., Relvas, J.B., Nishimura, S., Pytela, R., Edwards, G.M., Streuli, C.H., and ffrench-Constant, C. (1998). Neural precursor cell chain migration and division are regulated through different beta1 integrins. Development 125, 3167-3177.
Jaspars, L.H., Bonnet, P., Bloemena, E., and Meijer, C.J. (1996). Extracellular matrix and beta 1 integrin expression in nodal and extranodal T-cell lymphomas. J Pathol 178, 36-43.
Jingbo Qiao, Fang C. Mei, Vsevolod L. Popov, Leoncio A. Vergara, and Xiaodong Cheng. (2002). Cell Cycle-dependent Subcellular Localization of Exchange Factor Directly Activated by cAMP. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 26581–26586.
Wei Wong and John D. Scott. (2004). AKAP SIGNALLING COMPLEXES:FOCAL POINTS IN SPACE AND TIME. NATURE REVIEWS, MOLECULAR CELL BIOLOGY, 5, 959-970.
Johan de Rooij, Fried J. T. Zwartkruis, Mark H. G. Verheijen, Robbert H. Cool,
Sebastian M. B. Nijman, Alfred Wittinghofer & Johannes L. Bos. (1998). Epac is a Rap1 guanine nucleotide-exchange factor directly activated by cyclic AMP. NATURE, 396,474-477.
Kaneko, K., Satoh, K., Masamune, A., Satoh, A., and Shimosegawa, T. (2002). Myosin light chain kinase inhibitors can block invasion and adhesion of human pancreatic cancer cell lines. Pancreas 24, 34-41.
Kang, G., Chepurny, O.G., Rindler, M.J., Collis, L., Chepurny, Z., Li, W.H., Harbeck, M., Roe, M.W., and Holz, G.G. (2005). A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells. J Physiol 566, 173-188.
Khosravi-Far, R., Chrzanowska-Wodnicka, M., Solski, P.A., Eva, A., Burridge, K., and Der, C.J. (1994). Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras. Mol Cell Biol 14, 6848-6857.
Kiermayer, S., Biondi, R.M., Imig, J., Plotz, G., Haupenthal, J., Zeuzem, S., and Piiper, A. (2005). Epac activation converts cAMP from a proliferative into a differentiation signal in PC12 cells. Mol Biol Cell 16, 5639-5648.
Kiley, S.C., Clark, K.J., Duddy, S.K., Welch, D.R., and Jaken, S. (1999). Increased protein kinase C delta in mammary tumor cells: relationship to transformtion and metastatic progression. Oncogene 18, 6748-6757.
Klein, C.E., Steinmayer, T., Kaufmann, D., Weber, L., and Brocker, E.B. (1991). Identification of a melanoma progression antigen as integrin VLA-2. J Invest Dermatol 96, 281-284.
Klinowska, T.C., Soriano, J.V., Edwards, G.M., Oliver, J.M., Valentijn, A.J., Montesano, R., and Streuli, C.H. (1999). Laminin and beta1 integrins are crucial for normal mammary gland development in the mouse. Dev Biol 215, 13-32.
Kolega, J. (1981). The movement of cell clusters in vitro: morphology and directionality. J Cell Sci 49, 15-32.
Kraus, A.C., Ferber, I., Bachmann, S.O., Specht, H., Wimmel, A., Gross, M.W., Schlegel, J., Suske, G., and Schuermann, M. (2002). In vitro chemo- and radio-resistance in small cell lung cancer correlates with cell adhesion and constitutive activation of AKT and MAP kinase pathways. Oncogene 21, 8683-8695.
Kruger, A., Soeltl, R., Sopov, I., Kopitz, C., Arlt, M., Magdolen, V., Harbeck, N., Gansbacher, B., and Schmitt, M. (2001). Hydroxamate-type matrix metalloproteinase inhibitor batimastat promotes liver metastasis. Cancer Res 61, 1272-1275.
Katsaros, D., Tortora. G.. Tagliaferri. P.. Clair. T.. Ally. S., Neckers. L., Robins. R. K., and Cho-Chung, Y. S. (1987). Site-selective cyclic AMP analogs provide a new approach in the control of cancer cell growth. FEBS Letter, 225, 97-103.
Kimberly L. Dodge-Kafka, Joseph Soughayer, Genevieve C., Jennifer J. Carlisle Michel, Lorene K. Langeberg, Michael S. Kapiloff & John D. Scott. (2005). The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature letters, 437, 574-578.
Lambrechts, A., Kwiatkowski, A.V., Lanier, L.M., Bear, J.E., Vandekerckhove, J., Ampe, C., and Gertler, F.B. (2000). cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains. J Biol Chem 275, 36143-36151.
Lauffenburger, D.A., and Horwitz, A.F. (1996). Cell migration: a physically integrated molecular process. Cell 84, 359-369.
Li, C., Wernig, F., Leitges, M., Hu, Y., and Xu, Q. (2003). Mechanical stress-activated PKCdelta regulates smooth muscle cell migration. FASEB J 17, 2106-2108.
Lim, C.J., Han, J., Yousefi, N., Ma, Y., Amieux, P.S., McKnight, G.S., Taylor, S.S., and Ginsberg, M.H. (2007). Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nat Cell Biol 9, 415-421.
Lim, C.J., Kain, K.H., Tkachenko, E., Goldfinger, L.E., Gutierrez, E., Allen, M.D., Groisman, A., Zhang, J., and Ginsberg, M.H. (2008). Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell 19, 4930-4941.
Logue, J.S., Whiting, J.L., and Scott, J.D. (2011). Sequestering Rac with PKA confers cAMP control of cytoskeletal remodeling. Small Gtpases 2, 173-176.
Loureiro, J.J., Rubinson, D.A., Bear, J.E., Baltus, G.A., Kwiatkowski, A.V., and Gertler, F.B. (2002). Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration. Mol Biol Cell 13, 2533-2546.
Ludowyke, R.I., Kawasugi, K., and French, P.W. (1994). PMA and calcium ionophore induce myosin and F-actin rearrangement during histamine secretion from RBL-2H3 cells. Cell Motil Cytoskeleton 29, 354-365.
Lange-Carter, C. A., Fossli, T., Jahnsen, T., and Malkinson, A. M. (1990). Decreased expression of the type 1 isoenzyme of cAMP-dependent protein kinase in tumor cell lines of lung epithelial origin. J. Biol. Chem, 74, 7814-7818.
Lanotte M, Riviere JB, Hermouet S, Houge G, Vintermyr OK, Gjertsen BT, Døskeland SO. (1991). Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate-kinase I in a myeloid leukemia cell line. J Cell Physiology, 146, 73-80.
Madhavan, M., Srinivas, P., Abraham, E., Ahmed, I., Mathew, A., Vijayalekshmi, N.R., and Balaram, P. (2001). Cadherins as predictive markers of nodal metastasis in breast cancer. Mod Pathol 14, 423-427.
Mandeville, J.T., Lawson, M.A., and Maxfield, F.R. (1997). Dynamic imaging of neutrophil migration in three dimensions: mechanical interactions between cells and matrix. J Leukoc Biol 61, 188-200.
Masur, K., Lang, K., Niggemann, B., Zanker, K.S., and Entschladen, F. (2001). High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells. Mol Biol Cell 12, 1973-1982.
Mathur, A., Hong, Y., Martin, J., and Erusalimsky, J. (2001). Megakaryocytic differentiation is accompanied by a reduction in cell migratory potential. Br J Haematol 112, 459-465.
McKenzie, A.J., Campbell, S.L., and Howe, A.K. (2011). Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasion. PLoS One 6, e26552.
Moll, R., Mitze, M., Frixen, U.H., and Birchmeier, W. (1993). Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas. Am J Pathol 143, 1731-1742.
Nabeshima, K., Inoue, T., Shimao, Y., Okada, Y., Itoh, Y., Seiki, M., and Koono, M. (2000). Front-cell-specific expression of membrane-type 1 matrix metalloproteinase and gelatinase A during cohort migration of colon carcinoma cells induced by hepatocyte growth factor/scatter factor. Cancer Res 60, 3364-3369.
Netelenbos, T., Zuijderduijn, S., Van Den Born, J., Kessler, F.L., Zweegman, S., Huijgens, P.C., and Drager, A.M. (2002). Proteoglycans guide SDF-1-induced migration of hematopoietic progenitor cells. J Leukoc Biol 72, 353-362.
Newell-Litwa, K.A., and Horwitz, A.R. (2011). Cell migration: PKA and RhoA set the pace. Curr Biol 21, R596-598.
Ng, T., Parsons, M., Hughes, W.E., Monypenny, J., Zicha, D., Gautreau, A., Arpin, M., Gschmeissner, S., Verveer, P.J., Bastiaens, P.I., et al. (2001). Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility. EMBO J 20, 2723-2741.
Niu, M.Y., Mills, J.C., and Nachmias, V.T. (1997). Development of polarity in human erythroleukemia cells: roles of membrane ruffling and the centrosome. Cell Motil Cytoskeleton 36, 203-215.
Nakahara, H., Mueller, S.C., Nomizu, M., Yamada, Y., Yeh, Y., and Chen, W.T. (1998). Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia. J Biol Chem 273, 9-12.
Nurismah, M.I., Noriah, O., Suryati, M.Y., and Sharifah, N.A. (2008). E-cadherin expression correlates with histologic type but not tumour grade in invasive breast cancer. Asian Pac J Cancer Prev 9, 699-702.
Nada Ledinko and I-JA David Chan. (1984). Increase in Type I Cyclic Adenosine 3':5'-Monophosphate-dependent Protein Kinase Activity and Specific Accumulation of Type I Regulatory Subunits in Adenovirus Type 12-transformed Cells. CANCER RESEARCH 44, 2622-2627.
O'Connor, K.L., and Mercurio, A.M. (2001). Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells. J Biol Chem 276, 47895-47900.
Overall, C.M., and Lopez-Otin, C. (2002). Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer 2, 657-672.
Osgood, E. E. (1957). A unifying concept of the etiology of the leukemius, lymphomas, and cancers. J. Nail. Cancer Inst, 18, 155-166.
Pankova, K., Rosel, D., Novotny, M., and Brabek, J. (2010). The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells. Cell Mol Life Sci 67, 63-71.
Parent, C.A., and Devreotes, P.N. (1999). A cell's sense of direction. Science 284, 765-770.
Paulus, W., Baur, I., Beutler, A.S., and Reeves, S.A. (1996). Diffuse brain invasion of glioma cells requires beta 1 integrins. Lab Invest 75, 819-826.
Pinner, S., and Sahai, E. (2008). Imaging amoeboid cancer cell motility in vivo. J Microsc 231, 441-445.
Polette, M., Gilles, C., de Bentzmann, S., Gruenert, D., Tournier, J.M., and Birembaut, P. (1998). Association of fibroblastoid features with the invasive phenotype in human bronchial cancer cell lines. Clin Exp Metastasis 16, 105-112.
Putz, E., Witter, K., Offner, S., Stosiek, P., Zippelius, A., Johnson, J., Zahn, R., Riethmuller, G., and Pantel, K. (1999). Phenotypic characteristics of cell lines derived from disseminated cancer cells in bone marrow of patients with solid epithelial tumors: establishment of working models for human micrometastases. Cancer Res 59, 241-248.
Pierce. G. B., Nakanc. P. K., and Mazurkiewicz, J. E. (1974). Natural history of malignant stem cells. In: W. Nakahara. T. Ono, T. Sugimura, and H. Sugano (eds.), Differentiation and Control of Malignancy of Tumor Cells, Tokyo: University of Tokyo Press, 453-472.
Pierosandro Tagliaferri, Dionyssios Katsaros, Timothy Clair, Leonard Neckers,Roland K. Robins, and Yoon Sang Cho-Chung. (1988). Reverse Transformation of Harvey Murine Sarcoma Virus transformed NIH/ST3 Cells by Site-selective Cyclic AMP Analogs. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 263, 409-416.
Philip J. S. Stork and Tara J. Dillon. Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions. (2005). BLOOD, 106, 2952-2961.
Qiu, R.G., Chen, J., McCormick, F., and Symons, M. (1995). A role for Rho in Ras transformation. Proc Natl Acad Sci U S A 92, 11781-11785.
Rintoul, R.C., and Sethi, T. (2001). The role of extracellular matrix in small-cell lung cancer. Lancet Oncol 2, 437-442.
Robinson, E.E., Zazzali, K.M., Corbett, S.A., and Foty, R.A. (2003). Alpha5beta1 integrin mediates strong tissue cohesion. J Cell Sci 116, 377-386.
Rannels, S. R., and Corbin, J. D. (1980). Two different intrachain cAMP binding sites of cAMP-dependent protein kinases. J. Biol. Chem, 255, 7085-7088.
Sabbisetti, V.S., Chirugupati, S., Thomas, S., Vaidya, K.S., Reardon, D., Chiriva-Internati, M., Iczkowski, K.A., and Shah, G.V. (2005). Calcitonin increases invasiveness of prostate cancer cells: role for cyclic AMP-dependent protein kinase A in calcitonin action. Int J Cancer 117, 551-560.
RAKESH K. SRIVASTAVA, YOUL NAM LEE, KOHEI NOGUCHI, YUN GYU PARK, MATTHEW J. C. ELLIS, JIN-SOOK JEONG, SE NYUN KIM, AND YOON S. CHO-CHUNG. (1998). The RIIb regulatory subunit of protein kinase A binds to cAMP response element: An alternative cAMP signaling pathway. Proc. Natl. Acad. Sci. USA, 95, 6687–6692.
Sahai, E., and Marshall, C.J. (2003). Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol 5, 711-719.
Sakkab, D., Lewitzky, M., Posern, G., Schaeper, U., Sachs, M., Birchmeier, W., and Feller, S.M. (2000). Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL. J Biol Chem 275, 10772-10778.
Schirner, M., Herzberg, F., Schmidt, R., Streit, M., Schoning, M., Hummel, M., Kaufmann, C., Thiel, E., and Kreuser, E.D. (1998). Integrin alpha5beta1: a potent inhibitor of experimental lung metastasis. Clin Exp Metastasis 16, 427-435.
Schutze, K., Maniotis, A., and Schliwa, M. (1991). The position of the microtubule-organizing center in directionally migrating fibroblasts depends on the nature of the substratum. Proc Natl Acad Sci U S A 88, 8367-8371.
Seftor, E.A., Meltzer, P.S., Kirschmann, D.A., Pe'er, J., Maniotis, A.J., Trent, J.M., Folberg, R., and Hendrix, M.J. (2002). Molecular determinants of human uveal melanoma invasion and metastasis. Clin Exp Metastasis 19, 233-246.
Shannon, K.E., Keene, J.L., Settle, S.L., Duffin, T.D., Nickols, M.A., Westlin, M., Schroeter, S., Ruminski, P.G., and Griggs, D.W. (2004). Anti-metastatic properties of RGD-peptidomimetic agents S137 and S247. Clin Exp Metastasis 21, 129-138.
Shibasaki, T., Sunaga, Y., Fujimoto, K., Kashima, Y., and Seino, S. (2004). Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis. J Biol Chem 279, 7956-7961.
Sibony-Benyamini, H., and Gil-Henn, H. (2012). Invadopodia: The leading force. Eur J Cell Biol.
Simian, M., Hirai, Y., Navre, M., Werb, Z., Lochter, A., and Bissell, M.J. (2001). The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells. Development 128, 3117-3131.
Small, J.V., Kaverina, I., Krylyshkina, O., and Rottner, K. (1999). Cytoskeleton cross-talk during cell motility. FEBS Lett 452, 96-99.
Sood, A.K., Seftor, E.A., Fletcher, M.S., Gardner, L.M., Heidger, P.M., Buller, R.E., Seftor, R.E., and Hendrix, M.J. (2001). Molecular determinants of ovarian cancer plasticity. Am J Pathol 158, 1279-1288.
Stoker, M., and Perryman, M. (1985). An epithelial scatter factor released by embryo fibroblasts. J Cell Sci 77, 209-223.
Strobel, T., and Cannistra, S.A. (1999). Beta1-integrins partly mediate binding of ovarian cancer cells to peritoneal mesothelium in vitro. Gynecol Oncol 73, 362-367.
Sara S. Roscioni., Carolina R. S. Elzinga & Martina Schmidt. (2008). Epac: effectors and biological functions., review. Naunyn-Schmiedeberg’s Arch Pharmacol, 377, 345-357.
Sachs. L. (1978). Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukemia. Nature (Lond.), 274, 535-539.
Russel,D. H. (1978). Type I cyclic AMP-dependent protein kinase as a positive effector of growth. Adv. Cyclic Nucleotide Res, 9, 493-506.
Simon J.Cook, Bonnee Rubinfeld, Iris Albert and Frank McCormick. (1993).RapVl 2 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. The EMBO Journal, 12, 3475-3485.
Simone Kiermayer, Ricardo M. Biondi, Jochen Imig, Guido Plotz, Jorg Haupenthal, Stefan Zeuzem, and Albrecht Piiper. (2005). Epac Activation Converts cAMP from a Proliferative into a Differentiation Signal in PC12 Cells. Molecular Biology of the Cell, 16, 5639–5648.
Tang, S., Morgan, K.G., Parker, C., and Ware, J.A. (1997). Requirement for protein kinase C theta for cell cycle progression and formation of actin stress fibers and filopodia in vascular endothelial cells. J Biol Chem 272, 28704-28711.
Tester, A.M., Ruangpanit, N., Anderson, R.L., and Thompson, E.W. (2000). MMP-9 secretion and MMP-2 activation distinguish invasive and metastatic sublines of a mouse mammary carcinoma system showing epithelial-mesenchymal transition traits. Clin Exp Metastasis 18, 553-560.
Thiery, J.P. (2009). [Epithelial-mesenchymal transitions in cancer onset and progression]. Bull Acad Natl Med 193, 1969-1978; discussion 1978-1969.
Trikha, M., Timar, J., Lundy, S.K., Szekeres, K., Cai, Y., Porter, A.T., and Honn, K.V. (1997). The high affinity alphaIIb beta3 integrin is involved in invasion of human melanoma cells. Cancer Res 57, 2522-2528.
Tomofusa Fukuyama, Eisaburo Sueoka, Yasuhiro Sugio, Teruhisa Otsuka, Yoshiyuki Niho, Kiwamu Akagi1 and Tomoko Kozu. (2001). MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes. Oncogene, 20, 6225-6232.
Tiwari S, Felekkis K, Moon EY, Flies A, Sherr DH, Lerner A. (2004). Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis. Blood, 103, 2661–2667.
Tortora, G., Tagliaferri, P., Clair, T., Colamonici, O., Neckers, L. M., Robins, R. K., and Cho-Chung. Y. S. (1988). Site-selective cAMP analogs at micromolar concentrations induce growth arrest and differentiation of acute promyelocytic, chronic myelocytic, and acute lymphocytic human leukemia cell lines. Blood, 71, 230-233.
Tortora, G., Clair, T., and Cho-Chung, Y. S. (1990). An antisense oligodeoxynucleotide targeted against the type IIβ regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects. Proc. Nati. Acad. Sci. USA, 87, 705-708.
Vaughan, R.B., and Trinkaus, J.P. (1966). Movements of epithelial cell sheets in vitro. J Cell Sci 1, 407-413.
Voermans, C., Rood, P.M., Hordijk, P.L., Gerritsen, W.R., and van der Schoot, C.E. (2000). Adhesion molecules involved in transendothelial migration of human hematopoietic progenitor cells. Stem Cells 18, 435-443.
Volkov, Y., Long, A., McGrath, S., Ni Eidhin, D., and Kelleher, D. (2001). Crucial importance of PKC-beta(I) in LFA-1-mediated locomotion of activated T cells. Nat Immunol 2, 508-514.
Weaver, A.M. (2006). Invadopodia: specialized cell structures for cancer invasion. Clinical & experimental metastasis 23, 97-105.
Webb, S.E., Lee, K.K., Tang, M.K., and Ede, D.A. (1997). Fibroblast growth factors 2 and 4 stimulate migration of mouse embryonic limb myogenic cells. Dev Dyn 209, 206-216.
Wehland, J., Osborn, M., and Weber, K. (1979). Cell-to-substratum contacts in living cells: a direct correlation between interference-reflexion and indirect-immunofluorescence microscopy using antibodies against actin and alpha-actinin. Journal of cell science 37, 257-273.
Werr, J., Xie, X., Hedqvist, P., Ruoslahti, E., and Lindbom, L. (1998). beta1 integrins are critically involved in neutrophil locomotion in extravascular tissue In vivo. J Exp Med 187, 2091-2096.
Whittard, J.D., and Akiyama, S.K. (2001). Activation of beta1 integrins induces cell-cell adhesion. Exp Cell Res 263, 65-76.
Whittard, J.D., Craig, S.E., Mould, A.P., Koch, A., Pertz, O., Engel, J., and Humphries, M.J. (2002). E-cadherin is a ligand for integrin alpha2beta1. Matrix Biol 21, 525-532.
Wolf, K., Mazo, I., Leung, H., Engelke, K., von Andrian, U.H., Deryugina, E.I., Strongin, A.Y., Brocker, E.B., and Friedl, P. (2003a). Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol 160, 267-277.
Wolf, K., Muller, R., Borgmann, S., Brocker, E.B., and Friedl, P. (2003b). Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases. Blood 102, 3262-3269.
Wong, W., and Scott, J.D. (2004). AKAP signalling complexes: focal points in space and time. Nat Rev Mol Cell Biol 5, 959-970.
Worthylake, R.A., and Burridge, K. (2003). RhoA and ROCK promote migration by limiting membrane protrusions. J Biol Chem 278, 13578-13584.
Xu, X., Johnson, P., and Mueller, S.C. (2009). Breast cancer cell movement: imaging invadopodia by TIRF and IRM microscopy. Methods in molecular biology (Clifton, NJ) 571, 209-225.
Yamazaki, D., Kurisu, S., and Takenawa, T. (2009). Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates. Oncogene 28, 1570-1583.
Yan, X., Walkiewicz, M., Carlson, J., Leiphon, L., and Grove, B. (2009). Gravin dynamics regulates the subcellular distribution of PKA. Exp Cell Res 315, 1247-1259.
Young, M.R., Montpetit, M., Lozano, Y., Djordjevic, A., Devata, S., Matthews, J.P., Yedavalli, S., and Chejfec, G. (1995). Regulation of Lewis lung carcinoma invasion and metastasis by protein kinase A. Int J Cancer 61, 104-109.
Yokozaki. H., Clair, T., Mednieks, M.. Tortora, G., Ally, S., Merlo, G., and Cho-Chung. Y. S. (1989). Nuclear translocation of the regulatory subunit of type II protein kinase correlates with increased DNA (CRE)-protein binding activity in human cancer cell lines treated with site-selective analogs of cAMP. Proc. Am. Assoc. CANCER RESEARCH, 30.
Zucker, S., Cao, J., and Chen, W.T. (2000). Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment. Oncogene 19, 6642-6650.
Zutter, M.M., Santoro, S.A., Staatz, W.D., and Tsung, Y.L. (1995). Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells. Proc Natl Acad Sci U S A 92, 7411-7415.


論文全文使用權限
  • 同意授權校內瀏覽/列印電子全文服務,於2022-12-31起公開。
  • 同意授權校外瀏覽/列印電子全文服務,於2022-12-31起公開。


  • 如您有疑問,請聯絡圖書館
    聯絡電話:(06)2757575#65773
    聯絡E-mail:etds@email.ncku.edu.tw