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系統識別號 U0026-2408201212204400
論文名稱(中文) 職場員工病態大樓症候群之生物指標研究-評估適應負荷模式之可行性
論文名稱(英文) Exploration for biomarkers of sick building syndrome: feasibility study of allostatic load model
校院名稱 成功大學
系所名稱(中) 環境醫學研究所
系所名稱(英) Institute of Environmental and Occupational Health
學年度 100
學期 2
出版年 101
研究生(中文) 梁修豪
研究生(英文) Hsiu-Hao Liang
學號 s76981018
學位類別 碩士
語文別 中文
論文頁數 90頁
口試委員 指導教授-蘇慧貞
口試委員-李俊璋
口試委員-杜宗禮
口試委員-李慧玲
中文關鍵字 室內環境品質  病態大樓症候群  適應負荷模式  8-OHdG 
英文關鍵字 indoor air quality  sick building syndromes  allostatic load model  8-OhdG 
學科別分類
中文摘要 中文摘要
病態建築症候群 (Sick building syndrome, SBS) 係指人員在不良的室內環境內產生非特異性的症狀,但當離開此環境後,症狀則會減緩或消失。然而,個人因子如壓力等亦會引發人員產生類似SBS之症狀。目前研究採用的SBS評估方法多僅能呈現環境或個人因素等單一因子對SBS的影響,以至於無法更清楚瞭解影響SBS的主要因子,進而降低SBS的風險。回顧晚近文獻發現適應負荷模式 (Allostatic load model) 為一可反映環境與個人因子對個體生理機能造成影響之客觀指標。因此,本研究嘗試利用線性迴歸模式探討適應負荷模式與職場員工SBS的關係,及其表現是否會受到室內環境汙染物的濃度變化及個人因子的影響,並與過去研究採用的8-OHdG比較,以瞭解適應負荷模式的適用性。本研究共收集70人的健康指標、生物檢體及所處空間的環境品質指標,經分析發現 (1)可培養性真菌濃度與適應負荷模式有顯著相關,而8-OHdG則與相對濕度和光照度有顯著相關;(2) 適應負荷模式與8-OHdG和受試者的SBS表現均無顯著關係,但適應負荷中與代謝系統和受試者SBS的表現有顯著關係 (p<0.05);(3) 利用適應負荷模式的生物指標初步建構評估SBS嚴重程度之方程式為SBS總積分=0.311一秒用力吐氣量 (l) +0.276肌酸酐 (mg/dl) +0.189正腎上腺素 (μg/g creatinine) +0.117每週工作時數 (hr)-0.426性別 (女性:0;男性:1) -0.321種族 (漢人:1;非漢人:2)。此方程式之解釋力為40.1%,且達統計上顯著意義 (p=0.001)。本研究為第一篇探討適應負荷模式和SBS關係之研究,研究雖僅發現可培養性真菌濃度與適應負荷模式有顯著相關,且僅適應負荷模式中的代謝系統與SBS有顯著關係,但仍初步證實環境暴露與適應負荷模式有關,且適應負荷模式與SBS有關。因此,本研究結果也提供未來探討SBS影響因子的方向,以更深入釐清影響SBS的因素進而降低其風險。
英文摘要 Abstract
Sick building syndromes (SBS) include a group of non-specific symptoms, usually disappearing after leaving the suspected environments. Meanwhile, personal stress is also linked to reporting symptoms almost identical to those mentioned above. To assess the SBS, most studies have either taken the approach of questionnaires interview, or by measuring 8-OHdG levels only. None of the above can be considered to serve as a comprehensive surrogate for SBS severity. Allostatic load model, on the other hand, has been reported as an objective biomarker to reflect the effect of environmental exposure or personal stress. This study therefore aimed to assess the feasibility of using allostatic load model to characterize SBS and to examine the potential associations among environmental concentrations, personal factors and biomarkers of interest (8-OHdG). Health indicators and bio-samples (saliva and urine) were collected for 70 subjects, some of which were used to calculate allostatic Score. The quality of indoor air where these subjects worked was also measured. Results showed that allostatic load scores were significantly correlated with total culturable fungi, and 8-OHdG levels were with relative humidity and light intensity. No significant relations were found between allostatic load score and reporting SBS, but effect of metabolic system included in allostatic load model was positively associated with SBS. Association between 8-OHdG levels and reporting SBS was of no significance. Based on the study results, we proposed a model for estimating SBS severity as the following: SBS index= 0.311*forced expiratory volume in 1 second (FEV1, L)+0.276*creatinine (mg/dl) +0.189*norepinephrine (μg/g creatinine)+0.117*working hour (hr)-0.426*gender (female as 0, male as 1)-0.321*race (han as 1, nonhan as 2) (R2=0.401, p=0.001). This study was the first study to characterize the relation among allostatic load scores, reporting SBS, and environmental factors.
論文目次 目錄
致謝 i
中文摘要 iii
Abstract iv
目錄 v
表目錄 viii
圖目錄 ix
第一章 序論 1
1-1 研究緣起 1
1-2研究目的 3
第二章 文獻回顧 4
2-1室內環境品質 4
2-2 室內環境品質與人體健康效應 5
2-2-1建築物相關疾病 (Building Related Illness) 5
2-2-2病態大樓症候群 (Sick Building Syndrome) 7
2-3 生理指標發展現況與限制 10
2-4 適應性負荷模式 (Allostatic Load Model) 13
2-4-1 適應性負荷模式的發展 14
2-4-2 適應性負荷模式的應用 14
第三章 研究方法 17
3-1 研究對象選取 17
3-1-1 研究空間選取 17
3-1-2 受試者選取 17
3-2室內環境品質監測 18
3-3生理指標之量測與收集 20
3-4 適應負荷模式分數計算 22
3-5 問卷調查 23
3-5-1病態大樓症候群調查 23
3-5-2 生活品質分數計算 25
3-6統計分析 27
第四章 結果 28
4-1 研究場址之基本特徵 28
4-2 受試者基本特徵 29
4-3生活品質指標分佈 31
4-4 受試者所處室內環境因子分佈 34
4-5 適應負荷模式 (含所計算的指標) 與尿液中8-OHdG分佈 40
4-6 受試者SBS盛行率分佈 42
4-7 基本特性、生活品質及環境因子與適應負荷模式和8-OHdG的關係 44
4-8 適應負荷模式和8-OHdG與SBS表現的關係 49
4-9生活品質及環境因子與SBS表現的關係 51
4-10 小結 55
第五章 討論 57
5-1 受試者SBS盛行率分佈 57
5-2受試者適應負荷模式之分佈 59
5-3受試者尿液中8-OHdG濃度分佈 62
5-4生活品質與環境因子和適應負荷模式與8-OHdG之關係 63
5-4-1生活品質與環境因子和適應負荷模式之關係 63
5-4-2生活品質與環境因子和8-OHdG之關係 64
5-5適應負荷模式與8-OHdG和受試者SBS表現之關係 66
5-5-1適應負荷模式與受試者SBS表現之關係 66
5-5-2 受試者尿液中8-OHdG與受試者SBS表現之關係 67
5-6生活品質與環境因子和受試者SBS表現之關係 68
5-6-1生活品質與受試者SBS表現之關係 68
5-6-2環境因子與受試者SBS表現之關係 68
5-7研究限制 70
第六章 結論與建議 71
6-1結論 71
6-2建議 72
參考文獻 73
附錄 88
附錄一 臺灣版世界衛生組織生活品質問卷使用授權書 88
附錄二 同意臨床試驗證明書 89
附錄三 臨床試驗規範訓練結業證書 90
參考文獻 參考文獻
Alvarez MA, Portilla L, Gonzalez R, Ezcurra E. 1989. Insulin response to a short stress period. Psychoneuroendocrinology 14(3): 241-244.
Apter A, Bracker A, Hodgson M, Sidman J, Leung WY. 1994. Epidemiology of the sick building syndrome. The Journal of allergy and clinical immunology 94( 2): 277-288.
Arbex MA, Martins LC, Pereira LA, Negrini F, Cardoso AA, Melchert WR, et al. 2007. Indoor NO2 air pollution and lung function of professional cooks. Brazilian journal of medical and biological research 40(4): 527-534.
Bakke JV, Norback D, Wieslander G, Hollund BE, Moen BE. 2007. Pet keeping and dampness in the dwelling: associations with airway infections, symptoms, and physiological signs from the ocular and nasal mucosa. Indoor air 17(1): 60-69.
Banerjee A, Mondal NK, Das D, Ray MR. 2012. Neutrophilic Inflammatory Response and Oxidative Stress in Premenopausal Women Chronically Exposed to Indoor Air Pollution from Biomass Burning. Inflammation 35(2): 671-683.
Becker R FM, Verhoeff AP, Adan OCG, Hoekstra ES. 1994. Fungal disfigurement of constructionsFanalysis of the effects of various factors. Air Quality Monographs (2): 361-380.
Bellingrath S, Weigl T, Kudielka BM. 2009. Chronic work stress and exhaustion is associated with higher allostastic load in female school teachers. Stress 12(1): 37-48.
Berglund L G CWS. 1989. Perceived air quality and the thermal environment. The human equation: health and comfort proceedings IAQ(89): 93-99.
Berset M, Semmer NK, Elfering A, Jacobshagen N, Meier LL. 2011. Does stress at work make you gain weight? A two-year longitudinal study. Scandinavian journal of work, environment & health 37(1): 45-53.
Billionnet C, Gay E, Kirchner S, Leynaert B, Annesi-Maesano I. 2011. Quantitative assessments of indoor air pollution and respiratory health in a population-based sample of French dwellings. Environmental research 111(3): 425-434.
Bjorkroth M K SOA, Torkki A. 1998. Chemical and sensory emissions from HVAC components and ducts. USA, Atlanta, ASHRAE (American Society of Heating Refrigeration and Air Conditioning Engineers) 1998, ISBN 1-883413-66-4.
Bluyssen PM, Fernandes ED, Groes L, Clausen G, Fanger PO, Valbjorn O, et al. 1996. European indoor air quality audit project in 56 office buildings. Indoor Air-International Journal of Indoor Air Quality and Climate 6(4): 221-238.
Boxer PA. 1990. Indoor air quality: a psychosocial perspective. Journal of occupational medicine 32(5): 425-428.
Brasche S, Bullinger M, Morfeld M, Gebhardt HJ, Bischof W. 2001. Why do women suffer from sick building syndrome more often than men?--subjective higher sensitivity versus objective causes. Indoor air 11(4): 217-222.
Brightman HS, Milton DK, Wypij D, Burge HA, Spengler JD. 2008. Evaluating building-related symptoms using the US EPA BASE study results. Indoor air 18(4): 335-345.
Cain WS, Leaderer BP, Isseroff R, Berglund LG, Huey RJ, Lipsitt ED, et al. 1983. Ventilation Requirements in Buildings .1. Control of Occupancy Odor and Tobacco-Smoke Odor. Atmos Environ 17(6): 1183-1197.
Chao HJ, Schwartz J, Milton DK, Burge HA. 2003. The work environment and workers' health in four large office buildings. Environmental health perspectives 111(9): 1242-1248.
Chuang KJ, Yan YH, Cheng TJ. 2010. Effect of air pollution on blood pressure, blood lipids, and blood sugar: a population-based approach. Journal of occupational and environmental medicine 52(3): 258-262.
Clark MS, Bond MJ, Hecker JR. 2007. Environmental stress, psychological stress and allostatic load. Psychology, health & medicine 12(1): 18-30.
Colbjornsen T. 1982. Worker Protection at Bases - Work-Environment, Technical Strategy and Defense Cooperation in Oil Operations. Tidsskr Samfunnsfor 23(5-6): 635-636.
Cometto-Muniz JE, Cain WS, Abraham MH. 2004. Detection of single and mixed VOCs by smell and by sensory irritation. Indoor air 14(8): 108-117.
Crews DE, Harada H, Aoyagi K, Maeda T, Alfarano A, Sone Y, et al. 2012. A Pilot Study of Allostatic Load among Elderly Japanese Living on Hizen-Oshima Island. Journal of physiological anthropology 31(1): 18.
Cuthbertson BJ, Bullesbach EE, Gross PS. 2006. Discovery of synthetic penaeidin activity against antibiotic-resistant fungi. Chem Biol Drug Des 68(2): 120-127.
Dales R, Chen L, Frescura AM, Liu L, Villeneuve PJ. 2009. Acute effects of outdoor air pollution on forced expiratory volume in 1 s: a panel study of schoolchildren with asthma. European Respiratory Journal 34(2): 316-323.
Diaz E, Bruce N, Pope D, Lie RT, Diaz A, Arana B, et al. 2007. Lung function and symptoms among indigenous Mayan women exposed to high levels of indoor air pollution. The international journal of tuberculosis and lung disease 11(12): 1372-1379.
Doan SN, Evans GW. 2011. Maternal responsiveness moderates the relationship between allostatic load and working memory. Development and psychopathology 23(3): 873-880.
Dowd JB, Simanek AM, Aiello AE. 2009. Socio-economic status, cortisol and allostatic load: a review of the literature. International journal of epidemiology 38(5): 1297-1309.
Eisner MD, Wang Y, Haight TJ, Balmes J, Hammond SK, Tager IB. 2007. Secondhand smoke exposure, pulmonary function, and cardiovascular mortality. Annals of epidemiology 17(5): 364-373.
Elke K, Begerow J, Oppermann H, Kramer U, Jermann E, Dunemann L. 1999. Determination of selected microbial volatile organic compounds by diffusive sampling and dual-column capillary GC-FID--a new feasible approach for the detection of an exposure to indoor mould fungi? Journal of environmental monitoring (5): 445-452.
Elliott L, Longnecker MP, Kissling GE, London SJ. 2006. Volatile organic compounds and pulmonary function in the Third National Health and Nutrition Examination Survey, 1988-1994. Environmental health perspectives 114(8): 1210-1214.
Engvall K, Hult M, Corner R, Lampa E, Norback D, Emenius G. 2010. A new multiple regression model to identify multi-family houses with a high prevalence of sick building symptoms "SBS", within the healthy sustainable house study in Stockholm (3H). International archives of occupational and environmental health 83(1): 85-94.
Engvall K, Norrby C, Bandel J, Hult M, Norback D. 2000. Development of a multiple regression model to identify multi-family residential buildings with a high prevalence of sick building syndrome (SBS). Indoor air 10(2): 101-110.
Finger BC, Dinan TG, Cryan JF. 2012. The temporal impact of chronic intermittent psychosocial stress on high-fat diet-induced alterations in body weight. Psychoneuroendocrinology 37(6): 729-741.
Fisk WJ, Mirer AG, Mendell MJ. 2009. Quantitative relationship of sick building syndrome symptoms with ventilation rates. Indoor air 19(2): 159-165.
Fisk WJ, Rosenfeld AH. 1997. Estimates of improved productivity and health from better indoor environments. Indoor Air-International Journal of Indoor Air Quality and Climate 7(3): 158-172.
Flouris AD, Metsios GS, Carrillo AE, Jamurtas AZ, Gourgoulianis K, Kiropoulos T, et al. 2009. Acute and short-term effects of secondhand smoke on lung function and cytokine production. American journal of respiratory and critical care medicine 179(11): 1029-1033.
Forlenza MJ, Miller GE. 2006. Increased serum levels of 8-hydroxy-2'-deoxyguanosine in clinical depression. Psychosomatic medicine 68(1): 1-7.
Franklin P, Dingle P, Stick S. 2000. Raised exhaled nitric oxide in healthy children is associated with domestic formaldehyde levels. American journal of respiratory and critical care medicine 161(5): 1757-1759.
Gallo LC, Jimenez JA, Shivpuri S, Espinosa de los Monteros K, Mills PJ. 2011. Domains of chronic stress, lifestyle factors, and allostatic load in middle-aged Mexican-American women. Annals of behavioral medicine 41(1): 21-31.
Goldstein DS. 2012. Stress, Allostatic Load, Catecholamines, and Other Neurotransmitters in Neurodegenerative Diseases. Cellular and molecular neurobiology.
Gomzi M, Bobic J, Radosevic-Vidacek B, Macan J, Varnai VM, Milkovic-Kraus S, et al. 2007. Sick building syndrome: psychological, somatic, and environmental determinants. Archives of environmental & occupational health 62(3): 147-155.
Goodyer IM, Park RJ, Netherton CM, Herbert J. 2001. Possible role of cortisol and dehydroepiandrosterone in human development and psychopathology. The British journal of psychiatry 179: 243-249.
Gorny RL, Reponen T, Grinshpun SA, Willeke K. 2001. Source strength of fungal spore aerosolization from moldy building material. Atmos Environ 35(28): 4853-4862.
Groes L. 1995. A Statistical Analysis of Indoor Environmental Factors: Laboratory of Heating and Air Conditioning, Technical University of Denmark. The European IAQ-Audit Project.
Gross O, Gewies A, Finger K, Schafer M, Sparwasser T, Peschel C, et al. 2006. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442(7103): 651-656.
Gustafsson PE, Janlert U, Theorell T, Westerlund H, Hammarstrom A. 2011. Socioeconomic status over the life course and allostatic load in adulthood: results from the Northern Swedish Cohort. Journal of epidemiology and community health 65(11): 986-992.
Gwosdow AR, Nielsen R, Berglund LG, DuBois AB, Tremml PG. 1989. Effect of thermal conditions on the acceptability of respiratory protective devices on humans at rest. American Industrial Hygiene Association journal 50(4): 188-195.
Han YY, Donovan M, Sung FC. 2010. Increased urinary 8-hydroxy-2'-deoxyguanosine excretion in long-distance bus drivers in Taiwan. Chemosphere 79(9): 942-948.
Hansen AM, Meyer HW, Gyntelberg F. 2008. Building-related symptoms and stress indicators. Indoor air 18(6): 440-446.
Harney J, Trunov M, Grinshpun S, Willeke K, Choe K, Trakumas S, et al. 2000. Release of lead-containing particles from a wall enclosure. Journal for the science of occupational and environmental health and safety 61(5): 743-752.
Hasson D, Von Thiele Schwarz U, Lindfors P. 2009. Self-rated health and allostatic load in women working in two occupational sectors. Journal of health psychology 14(4): 568-577.
Herbert TB, Cohen S. 1993. Depression and immunity: a meta-analytic review. Psychological bulletin 113(3): 472-486.
Hoffmann B, Luttmann-Gibson H, Cohen A, Zanobetti A, de Souza C, Foley C, et al. 2012. Opposing Effects of Particle Pollution, Ozone, and Ambient Temperature on Arterial Blood Pressure. Environmental health perspectives 120(2): 241-246.
Hopwood CJ, Flato CG, Ambwani S, Garland BH, Morey LC. 2009. A comparison of Latino and Anglo socially desirable responding. Journal of clinical psychology 65(7): 769-780.
Horie G. 1985. Synthesized evalu-ation of noise, lighting and thermal conditions in a room. Proceedings of the International Conference of Noise Control Engineering (Krakow): 491-496.
Hospodsky D, Qian J, Nazaroff WW, Yamamoto N, Bibby K, Rismani-Yazdi H, et al. 2012. Human Occupancy as a Source of Indoor Airborne Bacteria. PloS one 7(4).
Hu P, Wagle N, Goldman N, Weinstein M, Seeman TE. 2007. The associations between socioeconomic status, allostatic load and measures of health in older Taiwanese persons: Taiwan social environment and biomarkers of aging study. Journal of biosocial science 39(4): 545-556.
Huang HB, Lai CH, Chen GW, Lin YY, Jaakkola JJ, Liou SH, et al. 2012. Traffic-related air pollution and DNA damage: a longitudinal study in Taiwanese traffic conductors. PloS one 7(5): e37412.
Huang YP, Li J, Ma WH, Cheng MM, Zhao JC, Yu JC. 2004. Efficient H2O2 oxidation of organic pollutants catalyzed by supported iron sulfophenylporphyrin under visible light irradiation. Journal of Physical Chemistry B 108(22): 7263-7270.
Hulin M, Moularat S, Kirchner S, Robine E, Mandin C. 2012. Positive associations between respiratory outcomes and fungal index in rural inhabitants of a representative sample of French dwellings. International journal of hygiene and environmental health(0).
Hun DE, Siegel JA, Morandi MT, Stock TH, Corsi RL. 2009. Cancer risk disparities between hispanic and non-hispanic white populations: the role of exposure to indoor air pollution. Environmental health perspectives 117(12): 1925-1931.
Huttunen K, Rintala H, Hirvonen MR, Vepsalainen A, Hyvarinen A, Meklin T, et al. 2008. Indoor air particles and bioaerosols before and after renovation of moisture-damaged buildings: the effect on biological activity and microbial flora. Environmental research 107(3): 291-298.
IARC. 2006. Formaldehyde, 2-butoxyethanol and 1-tert-butoxypropan-2-ol. IARC monographs on the evaluation of carcinogenic risks to humans. World Health Organization, International Agency for Research on Cancer 88: 1-478.
Kawakami N, Haratani T, Araki S. 1998. Job strain and arterial blood pressure, serum cholesterol, and smoking as risk factors for coronary heart disease in Japan. International archives of occupational and environmental health 71(6): 429-432.
Keski-Nisula L, Katila ML, Remes S, Heinonen S, Pekkanen J. 2009. Intrauterine bacterial growth at birth and risk of asthma and allergic sensitization among offspring at the age of 15 to 17 years. J Allergy Clin Immun 123(6): 1305-1311.
Kiecolt-Glaser JK, Stephens RE, Lipetz PD, Speicher CE, Glaser R. 1985. Distress and DNA repair in human lymphocytes. Journal of behavioral medicine 8(4): 311-320.
Kim JL, Elfman L, Mi Y, Wieslander G, Smedje G, Norback D. 2007. Indoor molds, bacteria, microbial volatile organic compounds and plasticizers in schools--associations with asthma and respiratory symptoms in pupils. Indoor air 17(2): 153-163.
Kim K, Park EY, Lee KH, Park JD, Kim YD, Hong YC. 2009. Differential oxidative stress response in young children and the elderly following exposure to PM(2.5). Environmental health and preventive medicine 14(1): 60-66.
Kimura S, Yamauchi H, Hibino Y, Iwamoto M, Sera K, Ogino K. 2006. Evaluation of urinary 8-hydroxydeoxyguanine in healthy Japanese people. Basic & clinical pharmacology & toxicology 98(5): 496-502.
Kinman G, Griffin M. 2008. Psychosocial factors and gender as predictors of symptoms associated with sick building syndrome. Stress Health 24(2): 165-171.
Klepeis NE, Nelson WC, Ott WR, Robinson JP, Tsang AM, Switzer P, et al. 2001. The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants. Journal of exposure analysis and environmental epidemiology 11(3): 231-252.
Kolarik B, Lagercrantz L, Sundell J. 2009. Nitric oxide in exhaled and aspirated nasal air as an objective measure of human response to indoor air pollution. Indoor air 19(2): 145-152.
Kop WJ, Weissman NJ, Zhu J, Bonsall RW, Doyle M, Stretch MR, et al. 2008. Effects of acute mental stress and exercise on inflammatory markers in patients with coronary artery disease and healthy controls. The american journal of cardiology 101(6): 767-773.
Korte SM, Koolhaas JM, Wingfield JC, McEwen BS. 2005. The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. Neuroscience and biobehavioral reviews 29(1): 3-38.
Kovesi T, Gilbert NL, Stocco C, Fugler D, Dales RE, Guay M, et al. 2007. Indoor air quality and the risk of lower respiratory tract infections in young Canadian Inuit children. Canadian Medical Association journal 177(2): 155-160.
Kumar H, Kumagai Y, Tsuchida T, Koenig PA, Satoh T, Guo Z, et al. 2009. Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal beta-glucan. Journal of immunology 183(12): 8061-8067.
Kurmi OP, Semple S, Simkhada P, Smith WC, Ayres JG. 2010. COPD and chronic bronchitis risk of indoor air pollution from solid fuel: a systematic review and meta-analysis. Thorax 65(3): 221-228.
Langley SJ, Goldthorpe S, Craven M, Morris J, Woodcock A, Custovic A. 2003. Exposure and sensitization to indoor allergens: association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma. The Journal of allergy and clinical immunology 112(2): 362-368.
Lee JT, Son JY, Cho YS. 2007. The adverse effects of fine particle air pollution on respiratory function in the elderly. The Science of the total environment 385(1-3): 28-36.
Lee MS, Hang JQ, Zhang FY, Dai HL, Su L, Christiani DC. 2012. In-home solid fuel use and cardiovascular disease: a cross-sectional analysis of the Shanghai Putuo study. Environ Health-Glob 11.
Lee MW, Chen ML, Lung SC, Tsai CJ, Yin XJ, Mao IF. 2010. Exposure assessment of PM2.5 and urinary 8-OHdG for diesel exhaust emission inspector. The Science of the total environment 408(3): 505-510.
Li TT, Liu ZR, Bai YH. 2008. Human cancer risk from the inhalation of formaldehyde in different indoor environments in Guiyang City, China. B Environ Contam Tox 81(2): 200-204.
Lin LY, Chen HW, Su TL, Hong GB, Huang LC, Chuang KJ. 2011. The effects of indoor particle exposure on blood pressure and heart rate among young adults: An air filtration-based intervention study. Atmos Environ 45(31): 5540-5544.
Lin MH, Liou SH, Chang CW, Huang IH, Strickland PT, Lai CH. 2011. An engineering intervention resulting in improvement in lung function and change in urinary 8-hydroxydeoxyguanosine among foundry workers in Taiwan. International archives of occupational and environmental health 84(2): 175-183.
Liu L, Poon R, Chen L, Frescura AM, Montuschi P, Ciabattoni G, et al. 2009. Acute Effects of Air Pollution on Pulmonary Function, Airway Inflammation, and Oxidative Stress in Asthmatic Children. Environmental health perspectives 117(4): 668-674.
Lopez-Duran NL, Kovacs M, George CJ. 2009. Hypothalamic-pituitary-adrenal axis dysregulation in depressed children and adolescents: a meta-analysis. Psychoneuroendocrinology 34(9): 1272-1283.
Lu CY, Ma YC, Lin JM, Chuang CY, Sung FC. 2007a. Oxidative DNA damage estimated by urinary 8-hydroxydeoxyguanosine and indoor air pollution among non-smoking office employees. Environmental research 103(3): 331-337.
Lu CY, Ma YC, Lin JM, Li CY, Lin RS, Sung FC. 2007b. Oxidative stress associated with indoor air pollution and sick building syndrome-related symptoms among office workers in Taiwan. Inhalation toxicology 19(1): 57-65.
Ma CM, Lin LY, Chen HW, Huang LC, Li JF, Chuang KJ. 2010. Volatile organic compounds exposure and cardiovascular effects in hair salons. Occup Med-Oxford 60(8): 624-630.
Mair CA, Cutchin MP, Kristen Peek M. 2011. Allostatic load in an environmental riskscape: The role of stressors and gender. Health & Place 17(4): 978-987.
Marmot AF, Eley J, Stafford M, Stansfeld SA, Warwick E, Marmot MG. 2006. Building health: an epidemiological study of "sick building syndrome" in the Whitehall II study. Occupational and environmental medicine 63(4): 283-289.
Mattei J, Demissie S, Falcon LM, Ordovas JM, Tucker K. 2010. Allostatic load is associated with chronic conditions in the Boston Puerto Rican Health Study. Social Science & Medicine 70(12): 1988-1996.
McEwen BS. 1998a. Protective and damaging effects of stress mediators. The New England journal of medicine 338(3): 171-179.
McEwen BS. 1998b. Stress, adaptation, and disease. Allostasis and allostatic load. Annals of the New York Academy of Sciences 840: 33-44.
Mendell MJ. 1993. Non-Specific Symptoms In Office Workers: A Review And Summary Of The Epidemiologic Literature. Indoor air 3(4): 227-236.
Mendell MJ. 2007. Indoor residential chemical emissions as risk factors for-respiratory and allergic effects in children: a review. Indoor air 17(4): 259-277.
Menzies D, Bourbeau J. 1997. Building-related illnesses. The New England journal of medicine 337(21): 1524-1531.
Miller GE, Freedland KE, Carney RM, Stetler CA, Banks WA. 2003. Pathways linking depression, adiposity, and inflammatory markers in healthy young adults. Brain, behavior, and immunity 17(4): 276-285.
Miller GE, Freedland KE, Duntley S, Carney RM. 2005. Relation of depressive symptoms to C-reactive protein and pathogen burden (cytomegalovirus, herpes simplex virus, Epstein-Barr virus) in patients with earlier acute coronary syndromes. The American journal of cardiology 95(3): 317-321.
Miller GE, Stetler CA, Carney RM, Freedland KE, Banks WA. 2002. Clinical depression and inflammatory risk markers for coronary heart disease. The American journal of cardiology 90(12): 1279-1283.
Molhave L, Kjaergaard SK, Sigsgaard T, Lebowitz M. 2005. Interaction between ozone and airborne particulate matter in office air. Indoor air 15(6): 383-392.
Mondal NK, Mukherjee B, Das D, Ray MR. 2010. Micronucleus formation, DNA damage and repair in premenopausal women chronically exposed to high level of indoor air pollution from biomass fuel use in rural India. Mutat Res-Gen Tox En 697(1-2): 47-54.
Murray EL, Brondi L, Kleinbaum D, McGowan JE, Van Mels C, Brooks WA, et al. 2012. Cooking fuel type, household ventilation, and the risk of acute lower respiratory illness in urban Bangladeshi children: a longitudinal study. Indoor air 22(2): 132-139.
Neuner R, Seidel HJ. 2006. Adaptation of office workers to a new building - Impaired well-being as part of the sick-building-syndrome. International journal of hygiene and environmental health 209(4): 367-375.
Nicas M, Nazaroff WW, Hubbard A. 2005. Toward understanding the risk of secondary airborne infection: emission of respirable pathogens. Journal of occupational and environmental hygiene 2(3): 143-154.
Nikulin M, Reijula K, Jarvis BB, Veijalainen P, Hintikka EL. 1997. Effects of intranasal exposure to spores of Stachybotrys atra in mice. Fundamental and applied toxicology 35(2): 182-188.
Nøjgaard JK, Christensen KB, Wolkoff P. 2005. The effect on human eye blink frequency of exposure to limonene oxidation products and methacrolein. Toxicology letters 156(2): 241-251.
Norback D, Nordstrom K. 2008. Sick building syndrome in relation to air exchange rate, CO(2), room temperature and relative air humidity in university computer classrooms: an experimental study. International archives of occupational and environmental health 82(1): 21-30.
Ogulei D, Hopke PK, Wallace LA. 2006. Analysis of indoor particle size distributions in an occupied townhouse using positive matrix factorization. Indoor air 16(3): 204-215.
Pan CH, Chan CC, Wu KY. 2008. Effects on Chinese restaurant workers of exposure to cooking oil fumes: a cautionary note on urinary 8-hydroxy-2'-deoxyguanosine. Cancer epidemiology 17(12): 3351-3357.
Park JH, Cox-Ganser JM, Kreiss K, White SK, Rao CY. 2008. Hydrophilic fungi and ergosterol associated with respiratory illness in a water-damaged building. Environmental health perspectives 116(1): 45-50.
Peden DB, Setzer RW, Devlin RB. 1995. Ozone Exposure Has Both a Priming Effect on Allergen-Induced Responses and an Intrinsic Inflammatory Action in the Nasal Airways of Perennially Allergic Asthmatics. American journal of respiratory and critical care medicine 151(5): 1336-1345.
Peek MK, Cutchin MP, Salinas JJ, Sheffield KM, Eschbach K, Stowe RP, et al. 2010. Allostatic Load Among Non-Hispanic Whites, Non-Hispanic Blacks, and People of Mexican Origin: Effects of Ethnicity, Nativity, and Acculturation. American journal of public health 100(5): 940-946.
Pope CA, 3rd, Burnett RT, Krewski D, Jerrett M, Shi Y, Calle EE, et al. 2009. Cardiovascular mortality and exposure to airborne fine particulate matter and cigarette smoke: shape of the exposure-response relationship. Circulation 120(11): 941-948.
Rashid M, Zimring C. 2008. A review of the empirical literature on the relationships between indoor environment and stress in health care and office settings - Problems and prospects of sharing evidence. Environ Behav 40(2): 151-190.
Rios JLD, Boechat JL, Gioda A, dos Santos CY, Neto FRD, Silva JRLE. 2009. Symptoms prevalence among office workers of a sealed versus a non-sealed building: Associations to indoor air quality. Environment international 35(8): 1136-1141.
Rogosch FA, Dackis MN, Cicchetti D. 2011. Child maltreatment and allostatic load: consequences for physical and mental health in children from low-income families. Development and psychopathology 23(4): 1107-1124.
Rossner P, Jr., Svecova V, Milcova A, Lnenickova Z, Solansky I, Sram RJ. 2008. Seasonal variability of oxidative stress markers in city bus drivers. Part I. Oxidative damage to DNA. Mutation research 642(1-2): 14-20.
Roy A, Chapman RS, Hu W, Wei F, Liu X, Zhang J. 2012. Indoor air pollution and lung function growth among children in four Chinese cities. Indoor air 22(1): 3-11.
Runeson R, Wahlstedt K, Wieslander G, Norback D. 2006. Personal and psychosocial factors and symptoms compatible with sick building syndrome in the Swedish workforce. Indoor air 16(6): 445-453.
Ryabinin AE. 2004. Rethinking homeostasis: Allostatic regulation in physiology and pathophysiology. Am J Hum Biol 16(2): 173-174.
Saijo Y, Kanazawa A, Araki A, Morimoto K, Nakayama K, Takigawa T, et al. 2011. Relationships between mite allergen levels, mold concentrations, and sick building syndrome symptoms in newly built dwellings in Japan. Indoor air 21(3): 253-263.
Sakano N, Wang DH, Takahashi N, Wang B, Sauriasari R, Kanbara S, et al. 2009. Oxidative stress biomarkers and lifestyles in Japanese healthy people. Journal of clinical biochemistry and nutrition 44(2): 185-195.
Samet JM, Marbury MC, Spengler JD. 1987. Health effects and sources of indoor air pollution. Part I. The American review of respiratory disease 136(6): 1486-1508.
Samet JM, Marbury MC, Spengler JD. 1988. Health effects and sources of indoor air pollution. Part II. The American review of respiratory disease 137(1): 221-242.
Schulkin J. 2003. Addiction to drugs: allostatic regulation under duress. In: Rethinking homestasis.
Seeman T, Glei D, Goldman N, Weinstein M, Singer B, Lin YH. 2004. Social relationships and allostatic load in Taiwanese elderly and near elderly. Social science & medicine 59(11): 2245-2257.
Seeman TE, Singer BH, Rowe JW, Horwitz RI, McEwen BS. 1997. Price of adaptation--allostatic load and its health consequences. MacArthur studies of successful aging. Archives of internal medicine 157(19): 2259-2268.
Seppanen O. 2008. Ventilation Strategies for Good Indoor Air Quality and Energy Efficiency. Int J Vent 6(4): 297-306.
Shelton BG, Kirkland KH, Flanders WD, Morris GK. 2002. Profiles of airborne fungi in buildings and outdoor environments in the United States. Applied and environmental microbiology 68(4): 1743-1753.
Sloan CD, Andrew AS, Gruber JF, Mwenda KM, Moore JH, Onega T, et al. 2012. Indoor and outdoor air pollution and lung cancer in New Hampshire and Vermont. Toxicol Environ Chem 94(3): 605-615.
Sloan MM. 2012. Unfair Treatment in the Workplace and Worker Well-Being: The Role of Coworker Support in a Service Work Environment. Work Occupation 39(1): 3-34.
Spanier AJ, Hornung R, Lierl M, Lanphear BP. 2006. Environmental exposures and exhaled nitric oxide in children with asthma. The Journal of pediatrics 149(2): 220-226.
Spanier AJ, Kahn RS, Hornung RW, Wang N, Sun G, Lierl MB, et al. 2009. Environmental exposures, nitric oxide synthase genes, and exhaled nitric oxide in asthmatic children. Pediatric pulmonology 44(8): 812-819.
Stark PC, Burge HA, Ryan LM, Milton DK, Gold DR. 2003. Fungal levels in the home and lower respiratory tract illnesses in the first year of life. American journal of respiratory and critical care medicine 168(2): 232-237.
Su SB, Wang BJ, Tai C, Chang HF, Guo HR. 2009. Higher prevalence of dry symptoms in skin, eyes, nose and throat among workers in clean rooms with moderate humidity. Journal of occupational health 51(4): 364-369.
Suglia SF, Duarte CS, Sandel MT, Wright RJ. 2010. Social and environmental stressors in the home and childhood asthma. Journal of epidemiology and community health 64(7): 636-642.
Sun J, Wang S, Zhang JQ, Li W. 2007. Assessing the cumulative effects of stress: The association between job stress and allostatic load in a large sample of Chinese employees. Work Stress 21(4): 333-347.
Sundblad BM, von Scheele I, Palmberg L, Olsson M, Larsson K. 2009. Repeated exposure to organic material alters inflammatory and physiological airway responses. European Respiratory Journal 34(1): 80-88.
Sundell J. 1996. What we know, and don`t know about sick building syndrome. ASHRAE 38(6): 51-57.
Swaab DF, Bao AM, Lucassen PJ. 2005. The stress system in the human brain in depression and neurodegeneration. Ageing research reviews 4(2): 141-194.
Takeda M, Saijo Y, Yuasa M, Kanazawa A, Araki A, Kishi R. 2009. Relationship between sick building syndrome and indoor environmental factors in newly built Japanese dwellings. International archives of occupational and environmental health 82(5): 583-593.
Takigawa T, Wang BL, Sakano N, Wang DH, Ogino K, Kishi R. 2009. A longitudinal study of environmental risk factors for subjective symptoms associated with sick building syndrome in new dwellings. The Science of the total environment 407(19): 5223-5228.
Triche EW, Belanger K, Bracken MB, Beckett WS, Holford TR, Gent JF, et al. 2005. Indoor heating sources and respiratory symptoms in nonsmoking women. Epidemiology 16(3): 377-384.
Tsai DH, Lin JS, Chan CC. 2012. Office workers' sick building syndrome and indoor carbon dioxide concentrations. Journal of occupational and environmental hygiene 9(5): 345-351.
Tsai SM, Wu SH, Hou MF, Chen YL, Ma H, Tsai LY. 2012. Oxidative stress-related enzyme gene polymorphisms and susceptibility to breast cancer in non-smoking, non-alcohol-consuming Taiwanese women: a case-control study. Annals of clinical biochemistry 49(Pt 2): 152-158.
Vaidya VS, Ford GM, Waikar SS, Wang YZ, Clement MB, Ramirez V, et al. 2009. A rapid urine test for early detection of kidney injury. Kidney international 76(1): 108-114.
Von Korff M, Alonso J, Ormel J, Angermeyer M, Bruffaerts R, Fleiz C, et al. 2009. Childhood psychosocial stressors and adult onset arthritis: broad spectrum risk factors and allostatic load. Pain 143(1-2): 76-83.
Wahlstedt K, Lindgren T, Norback D, Wieslander G, Runeson R. 2010. Psychosocial work environment and medical symptoms among Swedish commercial airline cabin crew. American journal of industrial medicine 53(7): 716-723.
Walinder R, Ernstgard L, Norback D, Wieslander G, Johanson G. 2008. Acute effects of 1-octen-3-ol, a microbial volatile organic compound (MVOC)--an experimental study. Toxicology letters 181(3): 141-147.
Wang BL, Takigawa T, Yamasaki Y, Sakano N, Wang DH, Ogino K. 2008. Symptom definitions for SBS (sick building syndrome) in residential dwellings. International journal of hygiene and environmental health 211(1-2): 114-120.
Wang XX, Gu Y, Fang YF, Huang YP. 2012. Mechanism of oxidative damage to DNA by Fe-loaded MCM-41 irradiated with visible light. Chinese Sci Bull 57(13): 1504-1509.
Weaver LK, Hopkins RO, Chan KJ, Churchill S, Elliott CG, Clemmer TP, et al. 2002. Hyperbaric oxygen for acute carbon monoxide poisoning. The New England journal of medicine 347(14): 1057-1067.
Weichenthal S, Dufresne A, Infante-Rivard C, Joseph L. 2007. Indoor ultrafine particle exposures and home heating systems: a cross-sectional survey of Canadian homes during the winter months. Journal of exposure science & environmental epidemiology 17(3): 288-297.
Weir MR. 2011. Short-term effects of vitamin D receptor activation on serum creatinine, creatinine generation, and glomerular filtration. Kidney international 80(10): 1016-1017.
WHO. 1984. Indoor Air quality research: EURO-reports and studies. 103.
WHO. 1984. Indoor air pollutants: exposure and health effects. Regional Office for Europe 78.
Wieslander G, Norback D. 2010. Ocular symptoms, tear film stability, nasal patency, and biomarkers in nasal lavage in indoor painters in relation to emissions from water-based paint. International archives of occupational and environmental health 83(7): 733-741.
Wilkins CK LK. 1995. Identification of volatile microbiological compounds from household waste and building materials by thermal desorption-capillary gas chromatography- mass spectroscopy. J High Resol Chromatogr(18): 373-377.
Wieslander G, Norback D, Venge P. 2007. Changes of symptoms, tear film stability and eosinophilic cationic protein in nasal lavage fluid after re-exposure to a damp office building with a history of flooding. Indoor air 17(1): 19-27.
Wong SK, Lai LWC, Ho DCW, Chau KW, Lam CLK, Ng CHF. 2009. Sick building syndrome and perceived indoor environmental quality: A survey of apartment buildings in Hong Kong. Habitat Int 33(4): 463-471.
Xu F, Yin X, Shen H, Xu Y, Ware RS, Owen N. 2007. Better understanding the influence of cigarette smoking and indoor air pollution on chronic obstructive pulmonary disease: a case-control study in Mainland China. Respirology 12(6): 891-897.
Yi S, Nanri A, Matsushita Y, Kasai H, Kawai K, Mizoue T. 2012. Depressive symptoms and oxidative DNA damage in Japanese municipal employees. Psychiatry research.
Yin B, Whyatt RM, Perera FP, Randall MC, Cooper TB, Santella RM. 1995. Determination of 8-hydroxydeoxyguanosine by an immunoaffinity chromatography-monoclonal antibody-based ELISA. Free Radical Biology and Medicine 18(6): 1023-1032.
Yoon HI, Hong YC, Cho SH, Kim H, Kim YH, Sohn JR, et al. 2010. Exposure to volatile organic compounds and loss of pulmonary function in the elderly. The Journal of the European Society for Clinical Respiratory Physiology 36(6): 1270-1276.
Zheng JP, Kang J, Huang SG, Chen P, Yao WZ, Yang L, et al. 2008. Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study. Lancet 371(9629): 2013-2018
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