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系統識別號 U0026-2408201010590900
論文名稱(中文) 利用雷射誘發電位及跨顱磁刺激探討主要感覺皮質區在疼痛與定位之區辨能力
論文名稱(英文) Primary somatosensory cortex in the discrimination of pain perception and its localization using laser and transcranial magnetic stimulation
校院名稱 成功大學
系所名稱(中) 認知科學研究所
系所名稱(英) Institute of Cognitive Science
學年度 98
學期 2
出版年 99
研究生(中文) 薛人瑞
研究生(英文) Jen-Jui Hseuh
學號 U7697405
學位類別 碩士
語文別 中文
論文頁數 68頁
口試委員 口試委員-徐百川
口試委員-嚴震東
指導教授-蕭富仁
中文關鍵字 痛覺  主要感覺皮質區  次要感覺皮質區  二氧化碳雷射刺激器  腦波儀  區辨能力  跨顱磁刺激 
英文關鍵字 Pain  Primary somatosensory cortex  Secondary somatosensory cortex  CO2 laser stimulator  Electroencephalogram  Discrimination  Transcranial magnetic stimulation 
學科別分類
中文摘要 痛覺會引發許多大腦區域的活化,例如與區辨能力相關之主要與次要感覺皮質區,為了進一步了解感覺皮質區在痛覺區辨功能的運作方式,本研究共設計兩個實驗來探討。實驗一、利用四種二氧化碳雷射刺激強度誘發疼痛,結合腦波儀記錄對側靠近主要與次要感覺皮質區之雷射誘發電位,結果顯示對側主要與次要感覺皮質區之雷射誘發電位起始時間點相近,而主要感覺皮層呈現與疼痛感覺相似的線性反應曲線,但次要感覺皮質呈現飽和型之反應曲線。實驗二、二氧化碳雷射刺激之後150或300毫秒在主要感覺皮質區給予跨顱磁刺激,跨顱磁刺激會顯著增高受試者之痛覺評分,而在高度疼痛感覺刺激下,其疼痛增加幅度較低。在高度疼痛感覺刺激後300毫秒,跨顱磁刺激造成受試者之空間定位能力顯著地下降。本研究證實主要感覺皮質區確實具有痛覺強度與空間區辨之能力,並且以強度相關方式調節疼痛空間區辨能力來處理痛覺。
英文摘要 Primary (SI) and secondary (SII) somatosensory cortices have been proposed to be associated with intensity and localization discrimination of noxious stimuli. To further clarify the discriminative function of somatosensory cortex in pain processing of humans, two experiments were carried out. First, laser-evoked potentials (LEPs) in response to four intensities of CO2 laser stimulation given over the dorsum of hand were compared. Onset latencies of contralateral SI (cSI) and SII (cSII) are comparable. A linear responsive pattern was found in peak-to-peak magnitude of cSI LEPs and pain rating with increased stimulus intensities. In contrast, an S-shape relationship was found between peak-to-peak magnitude of cSII LEPs and stimulus intensities. Moreover, single pulse transcranial magnetic stimulation (TMS) was applied over the cSI 150 or 300 ms after laser stimulation. Pain ratings were significantly elevated after TMS, particularly for high stimulus intensities. The localization error under a high stimulus intensity was significantly increased by TMS 300 ms after laser stimulation. Our results suggest that SI actually possess ability to discriminate both intensity and localization with a time-dependent and intensity-dependent manner.
論文目次 摘要..................................I
Abstract.............................II
誌謝................................III
目錄.................................IV
表目錄...............................VI
圖目錄..............................VII
符號...............................VIII
緒論..................................1
痛覺的神經解剖結構..................2
痛覺於大腦皮質上之處理方式..........5
研究動機與目的......................9
實驗一...............................11
研究方法...........................11
受試者...........................11
儀器與實驗設置...................12
二氧化碳雷射刺激器及強度定義...12
腦電波圖.......................15
環境設置及流程.................16
統計分析...........................18
結果與討論.........................19
實驗二...............................23
研究方法...........................23
受試者...........................23
儀器與實驗設置...................24
二氧化碳雷射刺激器與強度定義...24
跨顱磁刺激器及強度定義.........24
主要感覺皮質區之定位...........26
環境設置及流程.................26
統計分析...........................27
結果與討論.........................28
結論.................................34
未來工作.............................35
參考文獻.............................36
中文部分...........................36
英文部分...........................36

參考文獻 中文部分
中華民國疼痛醫學會(民92)。遠離疼痛(初版)。台北市:元氣齋。
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