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系統識別號 U0026-2307201502064900
論文名稱(中文) 芝麻油對脂多醣誘導大鼠敗血症腦部病變之影響
論文名稱(英文) Effects of sesame oil on lipopolysaccharide-induced sepsis-associated encephalopathy in rats
校院名稱 成功大學
系所名稱(中) 環境醫學研究所
系所名稱(英) Institute of Environmental and Occupational Health
學年度 103
學期 2
出版年 104
研究生(中文) 曹偉哲
研究生(英文) Wei-Che Tsao
學號 S76011083
學位類別 碩士
語文別 中文
論文頁數 67頁
口試委員 指導教授-劉明毅
口試委員-游一龍
口試委員-郭余民
口試委員-許德榮
中文關鍵字 敗血症  腦部病變  發炎  氧化壓力  芝麻油 
英文關鍵字 sepsis  encephalopathy  inflammation  oxidative stress  sesame oil 
學科別分類
中文摘要 敗血症是造成加護病房病人死亡的最主要原因,且敗血症的醫療照護成本高昂;敗血症所引起的腦部病變,被認為是因為感染引起的全身性發炎反應,所導致腦部功能障礙的結果,與敗血症的高致死率有關係。芝麻油是已知具有抗發炎能力的天然抗氧化物質,在眾多的動物研究中有治療疾病的潛力。然而,芝麻油對於敗血症引起腦部病變的影響,目前仍沒有被探討。因此本研究利用大鼠動物模式,探討芝麻油對敗血症引起腦部病變的影響。利用股靜脈注射的方式給予Wistar雄性大鼠單劑脂多醣(5 mg/kg)來誘導全身性發炎反應;全身性發炎反應症狀產生後,以口服灌食的方式給予大鼠芝麻油(0、2、4及8 ml/kg),觀察六小時再將大鼠犧牲,並收集腦部組織以及腦脊髓液。分析腦部組織中前細胞激素、一氧化氮、誘導型一氧化氮合成酶、核因子-κB、MyD88蛋白、骨髓過氧化酶,以及脂質過氧化物的生成或表現,利用免疫組織化學染色法觀察微膠細胞的活化程度,藉由病理切片觀察腦部組織的病理變化,此外分析腦脊髓液中總蛋白質含量,評估中樞神經系統受到的影響。結果顯示,口服給予一劑芝麻油,顯著降低酯多醣誘導敗血症對大鼠腦部組織中(1)前發炎細胞激素的表現量;(2)一氧化氮生成以及誘導型一氧化氮合成酶的表現;(3)調控發炎反應的核因子-κB表現;(4)微膠細胞、嗜中性球以及巨噬細胞的活化;(5)因為敗血症造成的腦神經壞死的情形;然而,芝麻油未對酯多醣誘導敗血症腦部MyD88蛋白活性、脂質過氧化物,以及腦脊髓液總蛋白造成影響。從結果得知,單一劑量芝麻油對降低脂多醣誘發大鼠敗血症所引起之腦部發炎有相當的潛力。
英文摘要 Sepsis, one of the major causes of mortality in the intensive care unit, produce substantial economic burden. Sepsis-associated encephalopathy (SAE) is considered a brain dysfunction as a consequence of systemic inflammatory response to an infection, which contributes to the mortality in septic patients. Sesame oil is a natural anti-oxidant with anti-inflammatory effect. It is possible that sesame oil attenuates SAE via its anti-inflammatory property; however, the effect of sesame oil on SAE has never been investigated. Therefore, the aim of this study was to investigate the effect and possible mechanism of sesame oil on SAE in rats. Sepsis was induced by lipopolysaccharide (LPS; 5 mg/kg, i.v.) in Wister rats. Sesame oil was given 6 h after LPS injection. Tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, nitric oxide (NO), inducible NO synthase (iNOS), nuclear factor (NF)-κB, myeloperoxidase (MPO), cerebrospinal fluid (CSF) protein and lipid peroxidation (LPO) levels were measured 6 h after sesame oil. Histopathologic examination of microglia activity and brain tissue were evaluated. Sesame oil significantly decreased brain TNF-α, IL-1β, and IL-6 levels; NO, iNOS, NF-κB and MPO activity. Sesame oil reduced brain microglia, neutrophil, and macrophage activity. Neuronal necrosis and gliosis were reduced after sesame oil treatment. However, sesame oil showed no effects on MyD88 activity, CSF protein and LPO levels. In conclusion, a single dose of sesame oil attenuates LPS-induced SAE by inhibiting brain inflammation in rats.
論文目次 中文摘要 I
英文摘要 II
誌謝 VII
目錄 IX
圖目錄 X
表目錄 XI
研究背景 1
研究目的 10
研究材料與方法 11
結果 27
討論 32
結論 38
參考文獻 39
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