進階搜尋


下載電子全文  
系統識別號 U0026-2207201711510200
論文名稱(中文) 研究早期生長反應-1及次發性副甲狀腺機能亢進在慢性腎臟病的角色
論文名稱(英文) Study for the roles of early growth response-1 and secondary hyperparathyroidism in chronic kidney disease
校院名稱 成功大學
系所名稱(中) 臨床醫學研究所
系所名稱(英) Institute of Clinical Medicine
學年度 105
學期 2
出版年 106
研究生(中文) 何立鈞
研究生(英文) Li-Chun Ho
學號 S98991047
學位類別 博士
語文別 英文
論文頁數 87頁
口試委員 召集委員-林水龍
口試委員-黃尚志
口試委員-張明熙
口試委員-呂佩融
指導教授-蔡曜聲
指導教授-宋俊明
中文關鍵字 早期生長反應-1  慢性腎臟病  副甲狀腺亢進 
英文關鍵字 Early growth response-1  chronic kidney disease  hyperparathyroidism 
學科別分類
中文摘要 慢性腎臟病是腎臟發炎及纖維化的綜合表現,其病患會有許多心血管風險因子,其中之一就是次發性副甲腺機能亢進。早期生長反應-1是一種鋅指轉錄因子,已知會參與許多組織的發炎及纖維化,但其在慢性腎臟病的角色尚未被完全了解。我的博士研究旨在調查早期生長反應-1及次發性副甲狀機能亢進是否有潛力作為治療標的以治療慢性腎臟病及其相關的死亡風險。發生腎小管間質炎的動物腎臟組織,以及有腎衰竭的人類腎臟組織,都顯示早期生長反應-1在腎小管的表現量上升並活化。早期生長反應-1基因剔除會干擾NF-κB造成的發炎反應及轉化生長因子-β造成的纖維化反應,因而腎衰竭的程度較輕微。不過,缺乏早期生長反應-1對發炎體的影響則較不明顯。體外初代培養近端腎小管細胞的實驗顯示,缺乏早期生長反應-1會抑制NF-κB並降低細胞對促發炎及促纖維化刺激的反應。以上發現都指出早期生長反應-1在腎衰竭過程中扮演起因的角色。至於針對次發性副甲狀腺機能亢進以治療慢性腎臟病病人的部份,我研究了副甲狀腺切除手術與透析病患長期死亡風險的相關性。本研究首次以曾接受副甲狀腺核子醫學掃描的病史作為篩選條件,以確保所有從全國透析資料庫挑出來的個案都有次發性副甲狀腺機能亢進。在核醫掃描之後切除副甲狀腺的透析病人,其粗死亡率低於未切除副甲狀腺的對照組病人。多變量Cox比例風險模式的分析顯示,副甲狀腺切除手術與死亡率減少20-25%有顯著相關。這些發現提供了低偏誤的證據來支持現行的臨床準則,亦即慢性腎臟病人若有難以控制的副甲狀腺機能亢進,應接受副甲狀腺切除手術。總結而言,本研究指出早期生長反應-1有作為慢性腎臟病治療標的的潛力,並顯示以副甲狀腺機能亢進作為治療標的並施予副甲狀腺切除手術,可有效降低透析病患的死亡率。這些研究成果增加了對早期生長反應-1與病理相關性的理解,並暗示了其臨床應用的價值。
英文摘要 Chronic kidney disease (CKD) consisting of renal inflammation and fibrosis is associated with many cardiovascular risk factors, and secondary hyperparathyroidism (SHPT) is one of them. Early growth response-1 (Egr-1) protein is a zinc-finger transcription factor participating in tissue inflammation and fibrosis, but its role in CKD is not fully understood. My PhD research aimed to investigate the potential of Egr-1 and SHPT as therapeutic targets for the treatment of CKD and associated mortality risk. The kidney tissues from animals with tubulointerstitial nephritis and from humans with renal failure both showed increased expression and activation of Egr-1 in renal tubules. Egr-1 deficiency in mice attenuated renal failure via interfering with NF-κB-mediated renal inflammation and transforming growth factor-β-mediated renal fibrosis, but the effect of Egr-1 deficiency on inflammasome was minor. The ex vivo studies using primary cultures of proximal tubular epithelial cells (PTECs) also showed that Egr-1 deficiency suppressed NF-κB pathway and attenuated the responses of PTECs to pro-inflammatory and pro-fibrotic stimulations. These findings suggested the causative role of Egr-1 in renal failure. As for targeting SHPT for the treatment of CKD patients, I studied the association between parathyroidectomy (PTx) and long-term mortality risk in dialysis patients. Histories of receiving radionuclide parathyroid scan were used, for the first time, as a selection criterion to ensure the presence of SHPT in all enrolled cases of a nationwide cohort of dialysis patients. The patients undergoing PTx after scanning had a lower crude mortality rate than the matched patients not undergoing PTx. The analysis of multivariable Cox proportional hazard model showed that PTx was independently associated with a 20% to 25% reduction of all-cause mortality rate. These findings provide minimally biased evidence to support current guidelines that PTx should be recommended for CKD patients with unremitting SHPT. To sum up, my thesis suggested that Egr-1 may serve as a potential therapeutic target for CKD and showed that targeting SHPT with PTx is effective in reducing mortality risk of CKD patients. The study results added to the understanding of pathological relevance of Egr-1 and suggest implications for clinical therapy.
論文目次 Chapeter 1 Introduction ...1
1.1 The discovery and the structure of Egr-1 and other Egr family members ...1
1.2 The regulation of Egr-1 ...3
1.3 The function of Egr-1 and other Egr family members ...5
1.4 Egr-1 and tissue injury-induced inflammation and fibrosis ...7
1.5 Egr-1 and kidney injury ...9
1.6 Egr-1 and cardiovascular disease ...10
1.7 Chronic kidney disease-mineral and bone disorder (CKD-MBD) ...11
1.8 Egr-1 and CKD-related vascular calcification ...13
1.9 Thesis Aims ...13
Chapeter 2 Egr-1 deficiency protects from renal inflammation and fibrosis ...15
2.1 Background and Aims ...15
2.2 Materials and Methods ...17
2.3 Results ...20
2.4 Discussion ...23
2.5 Figures and Tables ...29
Chapeter 3 Parathyroidectomy associates with reduced mortality in Taiwanese dialysis patients with hyperparathyroidism: Evidence for the controversy of current guidelines ...43
3.1 Background and Aims ...43
3.2 Methods ...45
3.3 Results ...50
3.4 Discussion ...53
3.5 Figures and Tables ...58
Chapeter 4 Summary and Prospects ...66
4.1 Major findings ...66
4.2 Future prospects ...67
Bibliography ...69
Publication lists ...87
參考文獻 Abdulkadir, S. A., J. M. Carbone, C. K. Naughton, P. A. Humphrey, W. J. Catalona and J. Milbrandt (2001a). "Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma." Hum Pathol 32(9): 935-939.
Abdulkadir, S. A., Z. Qu, E. Garabedian, S. K. Song, T. J. Peters, J. Svaren, J. M. Carbone, C. K. Naughton, W. J. Catalona, J. J. Ackerman, J. I. Gordon, P. A. Humphrey and J. Milbrandt (2001b). "Impaired prostate tumorigenesis in Egr1-deficient mice." Nat.Med. 7(1): 101-107.
Abnaof, K., N. Mallela, G. Walenda, S. K. Meurer, K. Sere, Q. Lin, B. Smeets, K. Hoffmann, W. Wagner, M. Zenke, R. Weiskirchen and H. Frohlich (2014). "TGF-beta stimulation in human and murine cells reveals commonly affected biological processes and pathways at transcription level." BMC Syst Biol 8: 55.
Akaberi, S., N. Clyne, G. Sterner, B. Rippe, E. Reihner, P. Wagner, R. Rylance, K. G. Prutz and M. Almquist (2014). "Temporal trends and risk factors for parathyroidectomy in the Swedish dialysis and transplant population - a nationwide, population-based study 1991 - 2009." BMC Nephrol 15: 75.
Allen, K., H. Jaeschke and B. L. Copple (2011). "Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis." Am J Pathol 178(1): 175-186.
Amann, K. (2008). "Media calcification and intima calcification are distinct entities in chronic kidney disease." Clin J Am Soc Nephrol 3(6): 1599-1605.
Andersen, K., N. Eltrich, J. Lichtnekert, H. J. Anders and V. Vielhauer (2014). "The NLRP3/ASC inflammasome promotes T-cell-dependent immune complex glomerulonephritis by canonical and noncanonical mechanisms." Kidney Int 86(5): 965-978.
Bavendiek, U., P. Libby, M. Kilbride, R. Reynolds, N. Mackman and U. Schonbeck (2002). "Induction of tissue factor expression in human endothelial cells by CD40 ligand is mediated via activator protein 1, nuclear factor kappa B, and Egr-1." J Biol Chem 277(28): 25032-25039.
Bea, F., E. Blessing, M. I. Shelley, J. M. Shultz and M. E. Rosenfeld (2003). "Simvastatin inhibits expression of tissue factor in advanced atherosclerotic lesions of apolipoprotein E deficient mice independently of lipid lowering: potential role of simvastatin-mediated inhibition of Egr-1 expression and activation." Atherosclerosis 167(2): 187-194.
Beckmann, A. M. and P. A. Wilce (1997). "Egr transcription factors in the nervous system." Neurochem Int 31(4): 477-510; discussion 517-476.
Bhattacharyya, S., S. J. Chen, M. Wu, M. Warner-Blankenship, H. Ning, G. Lakos, Y. Mori, E. Chang, C. Nihijima, K. Takehara, C. Feghali-Bostwick and J. Varga (2008). "Smad-independent transforming growth factor-beta regulation of early growth response-1 and sustained expression in fibrosis: implications for scleroderma." Am J Pathol 173(4): 1085-1099.
Bhattacharyya, S., F. Fang, W. Tourtellotte and J. Varga (2013). "Egr-1: new conductor for the tissue repair orchestra directs harmony (regeneration) or cacophony (fibrosis)." J Pathol 229(2): 286-297.
Bhattacharyya, S., W. Ishida, M. Wu, M. Wilkes, Y. Mori, M. Hinchcliff, E. Leof and J. Varga (2009). "A non-Smad mechanism of fibroblast activation by transforming growth factor-beta via c-Abl and Egr-1: selective modulation by imatinib mesylate." Oncogene 28(10): 1285-1297.
Bhattacharyya, S., J. L. Sargent, P. Du, S. Lin, W. G. Tourtellotte, K. Takehara, M. L. Whitfield and J. Varga (2011a). "Egr-1 induces a profibrotic injury/repair gene program associated with systemic sclerosis." PLoS.One. 6(9): e23082.
Bhattacharyya, S., M. Wu, F. Fang, W. Tourtellotte, C. Feghali-Bostwick and J. Varga (2011b). "Early growth response transcription factors: key mediators of fibrosis and novel targets for anti-fibrotic therapy." Matrix Biol. 30(4): 235-242.
Bhindi, R., R. G. Fahmy, A. C. McMahon, L. M. Khachigian and H. C. Lowe (2012). "Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion." J Pathol 227(2): 157-164.
Bhindi, R., L. M. Khachigian and H. C. Lowe (2006). "DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats." J Thromb Haemost 4(7): 1479-1483.
Block, G. A., P. S. Klassen, J. M. Lazarus, N. Ofsthun, E. G. Lowrie and G. M. Chertow (2004). "Mineral metabolism, mortality, and morbidity in maintenance hemodialysis." J Am Soc Nephrol 15(8): 2208-2218.
Bonventre, J. V., V. P. Sukhatme, M. Bamberger, A. J. Ouellette and D. Brown (1991). "Localization of the protein product of the immediate early growth response gene, Egr-1, in the kidney after ischemia and reperfusion." Cell Regul 2(3): 251-260.
Bover, J., P. Urena, V. Brandenburg, D. Goldsmith, C. Ruiz, I. DaSilva and R. J. Bosch (2014). "Adynamic bone disease: from bone to vessels in chronic kidney disease." Semin Nephrol 34(6): 626-640.
Buitrago, M., K. Lorenz, A. H. Maass, S. Oberdorf-Maass, U. Keller, E. M. Schmitteckert, Y. Ivashchenko, M. J. Lohse and S. Engelhardt (2005). "The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy." Nat Med 11(8): 837-844.
Cao, X., R. Mahendran, G. R. Guy and Y. H. Tan (1993). "Detection and characterization of cellular EGR-1 binding to its recognition site." J Biol Chem 268(23): 16949-16957.
Cao, Y., J. Zhang, X. Meng and D. Wang (2013). "TNF-alpha induces early growth response gene-1 expression via ERK1/2 activation in endothelial cells." Acta Diabetol 50(1): 27-31.
Carew, R. M., B. Wang and P. Kantharidis (2012). "The role of EMT in renal fibrosis." Cell Tissue Res 347(1): 103-116.
Chapman, N. R. and N. D. Perkins (2000). "Inhibition of the RelA(p65) NF-kappaB subunit by Egr-1." J Biol Chem 275(7): 4719-4725.
Charolidi, N., G. Pirianov, E. Torsney, S. Pearce, K. Laing, A. Nohturfft and G. W. Cockerill (2015). "Pioglitazone Identifies a New Target for Aneurysm Treatment: Role of Egr1 in an Experimental Murine Model of Aortic Aneurysm." J Vasc Res 52(2): 81-93.
Chen, G. and D. V. Goeddel (2002). "TNF-R1 signaling: a beautiful pathway." Science 296(5573): 1634-1635.
Chen, N. X., K. D. O'Neill, D. Duan and S. M. Moe (2002). "Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells." Kidney Int 62(5): 1724-1731.
Chen, S. J., H. Ning, W. Ishida, S. Sodin-Semrl, S. Takagawa, Y. Mori and J. Varga (2006). "The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression." J.Biol.Chem. 281(30): 21183-21197.
Chen, W. C., H. H. Lin and M. J. Tang (2014). "Regulation of proximal tubular cell differentiation and proliferation in primary culture by matrix stiffness and ECM components." Am J Physiol Renal Physiol 307(6): F695-707.
Cheng, M. C., Y. A. Chuang, C. L. Lu, Y. J. Chen, S. U. Luu, J. M. Li, S. H. Hsu and C. H. Chen (2012). "Genetic and functional analyses of early growth response (EGR) family genes in schizophrenia." Prog Neuropsychopharmacol Biol Psychiatry 39(1): 149-155.
Cheong, M. W., L. H. Kuo, Y. N. Cheng, P. J. Tsai, L. C. Ho, H. C. Tai, W. T. Chiu, S. H. Chen, P. J. Lu, Y. S. Shan, L. M. Chuang and Y. S. Tsai (2015). "Loss of Egr-1 sensitizes pancreatic beta-cells to palmitate-induced ER stress and apoptosis." J Mol Med (Berl) 93(7): 807-818.
Chevalier, R. L., M. S. Forbes and B. A. Thornhill (2009). "Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy." Kidney Int 75(11): 1145-1152.
Chien, C. C., J. J. Wang, Y. M. Sun, D. P. Sun, M. J. Sheu, S. F. Weng, C. C. Chu, H. A. Chen, C. C. Chio, J. C. Hwang, Y. H. Lu, H. Y. Wang and W. C. Kan (2012). "Long-term survival and predictors for mortality among dialysis patients in an endemic area for chronic liver disease: a national cohort study in Taiwan." BMC Nephrol 13: 43.
Cho, S. J., M. J. Kang, R. J. Homer, H. R. Kang, X. Zhang, P. J. Lee, J. A. Elias and C. G. Lee (2006). "Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling." J Biol Chem 281(12): 8161-8168.
Christy, B. and D. Nathans (1989). "DNA binding site of the growth factor-inducible protein Zif268." Proc Natl Acad Sci U S A 86(22): 8737-8741.
Chuang, C. H., J. J. Wang, S. F. Weng, K. M. Chung, Y. P. Chen, C. C. Huang, C. M. Yang and C. C. Chien (2013). "Epidemiology and mortality among dialysis patients with parathyroidectomy: Taiwan National Cohort Study." J Nephrol 26(6): 1143-1150.
Cogswell, P. C., M. W. Mayo and A. S. Baldwin, Jr. (1997). "Involvement of Egr-1/RelA synergy in distinguishing T cell activation from tumor necrosis factor-alpha-induced NF-kappa B1 transcription." J Exp Med 185(3): 491-497.
Collins, A. J., R. N. Foley, B. Chavers, D. Gilbertson, C. Herzog, A. Ishani, K. Johansen, B. L. Kasiske, N. Kutner, J. Liu, W. St Peter, H. Guo, Y. Hu, A. Kats, S. Li, S. Li, J. Maloney, T. Roberts, M. Skeans, J. Snyder, C. Solid, B. Thompson, E. Weinhandl, H. Xiong, A. Yusuf, D. Zaun, C. Arko, S. C. Chen, F. Daniels, J. Ebben, E. Frazier, R. Johnson, D. Sheets, X. Wang, B. Forrest, D. Berrini, E. Constantini, S. Everson, P. Eggers and L. Agodoa (2014). "US Renal Data System 2013 Annual Data Report." Am J Kidney Dis 63(1 Suppl): A7.
Conzo, G., A. F. Perna, V. Savica, A. Palazzo, C. Della Pietra, D. Ingrosso, E. Satta, G. Capasso, L. Santini and G. Docimo (2013). "Impact of parathyroidectomy on cardiovascular outcomes and survival in chronic hemodialysis patients with secondary hyperparathyroidism. A retrospective study of 50 cases prior to the calcimimetics era." BMC Surg 13 Suppl 2: S4.
Cormen, T. H., C. E. Leiserson, R. L. Rivest and C. Stein (1990). Greedy Algorithms. Introduction to Algorithms, MIT Press and McGraw-Hill.
Correa-Costa, M., T. T. Braga, P. Semedo, C. Y. Hayashida, L. R. Bechara, R. M. Elias, C. R. Barreto, C. Silva-Cunha, M. I. Hyane, G. M. Goncalves, P. C. Brum, C. Fujihara, R. Zatz, A. Pacheco-Silva, D. S. Zamboni and N. O. Camara (2011). "Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis." PLoS One 6(12): e29004.
Costa-Hong, V., V. Jorgetti, L. H. Gowdak, R. M. Moyses, E. M. Krieger and J. J. De Lima (2007). "Parathyroidectomy reduces cardiovascular events and mortality in renal hyperparathyroidism." Surgery 142(5): 699-703.
Crosby, S. D., R. A. Veile, H. Donis-Keller, J. M. Baraban, R. V. Bhat, K. S. Simburger and J. Milbrandt (1992). "Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C." Proc Natl Acad Sci U S A 89(10): 4739-4743.
Derdak, Z., K. A. Villegas and J. R. Wands (2012). "Early growth response-1 transcription factor promotes hepatic fibrosis and steatosis in long-term ethanol-fed Long-Evans rats." Liver Int 32(5): 761-770.
Do, K. H., H. J. Choi, J. Kim, S. H. Park, H. H. Kim, C. G. Oh and Y. Moon (2012). "Ambivalent roles of early growth response 1 in inflammatory signaling following ribosomal insult in human enterocytes." Biochem Pharmacol 84(4): 513-521.
Eddy, A. A. (2014). "Overview of the cellular and molecular basis of kidney fibrosis." Kidney Int Suppl (2011) 4(1): 2-8.
Fang, F., K. Ooka, S. Bhattacharyya, J. Wei, M. Wu, P. Du, S. Lin, F. Del Galdo, C. A. Feghali-Bostwick and J. Varga (2011). "The early growth response gene Egr2 (Alias Krox20) is a novel transcriptional target of transforming growth factor-beta that is up-regulated in systemic sclerosis and mediates profibrotic responses." Am J Pathol 178(5): 2077-2090.
Farivar, A. S., B. C. Mackinnon-Patterson, A. D. Barnes, A. S. McCourtie and M. S. Mulligan (2005). "Cyclosporine modulates the response to hypoxia-reoxygenation in pulmonary artery endothelial cells." Ann Thorac Surg 79(3): 1010-1016.
Fichtner-Feigl, S., C. A. Young, A. Kitani, E. K. Geissler, H. J. Schlitt and W. Strober (2008). "IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis." Gastroenterology 135(6): 2003-2013, 2013 e2001-2007.
Floege, J., J. Kim, E. Ireland, C. Chazot, T. Drueke, A. de Francisco, F. Kronenberg, D. Marcelli, J. Passlick-Deetjen, G. Schernthaner, B. Fouqueray, D. C. Wheeler and A. R. O. Investigators (2011). "Serum iPTH, calcium and phosphate, and the risk of mortality in a European haemodialysis population." Nephrol Dial Transplant 26(6): 1948-1955.
Friedrich, B., A. Janessa, F. Artunc, W. K. Aicher, G. A. Muller, F. Lang, T. Risler and D. Alexander (2008). "DOCA and TGF-beta induce early growth response gene-1 (Egr-1) expression." Cell Physiol Biochem. 22(5-6): 465-474.
Fukagawa, M. and S. Nakanishi (2003). "Role of parathyroid intervention in the management of secondary hyperparathyroidism." Nephrol Dial Transplant 18 Suppl 3: iii23-26.
Gaggioli, C., M. Deckert, G. Robert, P. Abbe, M. Batoz, M. U. Ehrengruber, J. P. Ortonne, R. Ballotti and S. Tartare-Deckert (2005). "HGF induces fibronectin matrix synthesis in melanoma cells through MAP kinase-dependent signaling pathway and induction of Egr-1." Oncogene 24(8): 1423-1433.
Gallitano-Mendel, A., Y. Izumi, K. Tokuda, C. F. Zorumski, M. P. Howell, L. J. Muglia, D. F. Wozniak and J. Milbrandt (2007). "The immediate early gene early growth response gene 3 mediates adaptation to stress and novelty." Neuroscience 148(3): 633-643.
Garcia-Sanchez, O., F. J. Lopez-Hernandez and J. M. Lopez-Novoa (2010). "An integrative view on the role of TGF-beta in the progressive tubular deletion associated with chronic kidney disease." Kidney Int 77(11): 950-955.
Gashler, A. L., S. Swaminathan and V. P. Sukhatme (1993). "A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1." Mol Cell Biol 13(8): 4556-4571.
Ghazvini-Boroujerdi, M., J. Clark, N. Narula, E. Palmatory, J. M. Connolly, S. DeFelice, J. Xu, B. Jian, S. Hazelwood and R. J. Levy (2004). "Transcription factor Egr-1 in calcific aortic valve disease." J Heart Valve Dis 13(6): 894-903.
Go, A. S., G. M. Chertow, D. Fan, C. E. McCulloch and C. Y. Hsu (2004). "Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization." N Engl J Med 351(13): 1296-1305.
Guha, M., M. A. O'Connell, R. Pawlinski, A. Hollis, P. McGovern, S. F. Yan, D. Stern and N. Mackman (2001). "Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression." Blood 98(5): 1429-1439.
Hadziselimovic, F., N. O. Hadziselimovic, P. Demougin, G. Krey, B. Hoecht and E. J. Oakeley (2009). "EGR4 is a master gene responsible for fertility in cryptorchidism." Sex Dev 3(5): 253-263.
Harja, E., L. G. Bucciarelli, Y. Lu, D. M. Stern, Y. S. Zou, A. M. Schmidt and S. F. Yan (2004). "Early growth response-1 promotes atherogenesis: mice deficient in early growth response-1 and apolipoprotein E display decreased atherosclerosis and vascular inflammation." Circ.Res. 94(3): 333-339.
Hemmelgarn, B. R., F. Clement, B. J. Manns, S. Klarenbach, M. T. James, P. Ravani, N. Pannu, S. B. Ahmed, J. MacRae, N. Scott-Douglas, K. Jindal, R. Quinn, B. F. Culleton, N. Wiebe, R. Krause, L. Thorlacius and M. Tonelli (2009). "Overview of the Alberta Kidney Disease Network." BMC Nephrol 10: 30.
Hjoberg, J., L. Le, A. Imrich, V. Subramaniam, S. I. Mathew, J. Vallone, K. J. Haley, F. H. Green, S. A. Shore and E. S. Silverman (2004). "Induction of early growth-response factor 1 by platelet-derived growth factor in human airway smooth muscle." Am J Physiol Lung Cell Mol Physiol 286(4): L817-825.
Hughes-Fulford, M. and C. F. Li (2011). "The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization." J Orthop Surg Res 6: 8.
Humphreys, B. D., S. L. Lin, A. Kobayashi, T. E. Hudson, B. T. Nowlin, J. V. Bonventre, M. T. Valerius, A. P. McMahon and J. S. Duffield (2010). "Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis." Am J Pathol 176(1): 85-97.
Hwang, S. J., J. C. Tsai and H. C. Chen (2010). "Epidemiology, impact and preventive care of chronic kidney disease in Taiwan." Nephrology (Carlton) 15 Suppl 2: 3-9.
Investigators, E. T., G. M. Chertow, G. A. Block, R. Correa-Rotter, T. B. Drueke, J. Floege, W. G. Goodman, C. A. Herzog, Y. Kubo, G. M. London, K. W. Mahaffey, T. C. Mix, S. M. Moe, M. L. Trotman, D. C. Wheeler and P. S. Parfrey (2012). "Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis." N Engl J Med 367(26): 2482-2494.
Ishani, A., J. Liu, J. B. Wetmore, K. A. Lowe, T. Do, B. D. Bradbury, G. A. Block and A. J. Collins (2015). "Clinical outcomes after parathyroidectomy in a nationwide cohort of patients on hemodialysis." Clin J Am Soc Nephrol 10(1): 90-97.
Iwamoto, N., N. Sato, M. Nishida, T. Hashimoto, H. Kobayashi, S. Yamasaki, T. Ono, M. Nishimura, T. Tokoro, C. Sakoda, M. Murakawa, K. Okino, Y. Okamoto, R. Imai, N. Adachi, K. Ninomiya, H. Mabuchi, M. Koyama, T. Nakanouchi and K. Iseki (2012). "Total parathyroidectomy improves survival of hemodialysis patients with secondary hyperparathyroidism." J Nephrol 25(5): 755-763.
Iyoda, T., F. Zhang, L. Sun, F. Hao, C. Schmitz-Peiffer, X. Xu and M. Z. Cui (2012). "Lysophosphatidic acid induces early growth response-1 (Egr-1) protein expression via protein kinase Cdelta-regulated extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activation in vascular smooth muscle cells." J Biol Chem 287(27): 22635-22642.
Ji, B., X. Q. Chen, D. E. Misek, R. Kuick, S. Hanash, S. Ernst, R. Najarian and C. D. Logsdon (2003). "Pancreatic gene expression during the initiation of acute pancreatitis: identification of EGR-1 as a key regulator." Physiol Genomics 14(1): 59-72.
Joannidis, M., L. G. Cantley, K. Spokes, A. K. Stuart-Tilley, S. L. Alper and F. H. Epstein (1997). "Modulation of c-fos and egr-1 expression in the isolated perfused kidney by agents that alter tubular work." Kidney Int 52(1): 130-139.
Jofre, R., J. M. Lopez Gomez, J. Menarguez, J. R. Polo, M. Guinsburg, T. Villaverde, I. Perez Flores, D. Carretero, P. Rodriguez Benitez and R. Perez Garcia (2003). "Parathyroidectomy: whom and when?" Kidney Int Suppl 63: S97-100.
Jones, M. W., M. L. Errington, P. J. French, A. Fine, T. V. Bliss, S. Garel, P. Charnay, B. Bozon, S. Laroche and S. Davis (2001). "A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories." Nat Neurosci 4(3): 289-296.
Jono, S., M. D. McKee, C. E. Murry, A. Shioi, Y. Nishizawa, K. Mori, H. Morii and C. M. Giachelli (2000). "Phosphate regulation of vascular smooth muscle cell calcification." Circ Res 87(7): E10-17.
Jorna, F. H., T. J. Tobe, R. M. Huisman, P. E. de Jong, J. T. Plukker and C. A. Stegeman (2004). "Early identification of risk factors for refractory secondary hyperparathyroidism in patients with long-term renal replacement therapy." Nephrol Dial Transplant 19(5): 1168-1173.
Joseph, L. J., M. M. Le Beau, G. A. Jamieson, Jr., S. Acharya, T. B. Shows, J. D. Rowley and V. P. Sukhatme (1988). "Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure." Proc Natl Acad Sci U S A 85(19): 7164-7168.
Kaufmann, K. and G. Thiel (2002). "Epidermal growth factor and thrombin induced proliferation of immortalized human keratinocytes is coupled to the synthesis of Egr-1, a zinc finger transcriptional regulator." J Cell Biochem 85(2): 381-391.
Kawata, T., N. Nagano, M. Obi, S. Miyata, C. Koyama, N. Kobayashi, S. Wakita and M. Wada (2008). "Cinacalcet suppresses calcification of the aorta and heart in uremic rats." Kidney Int 74(10): 1270-1277.
Kestenbaum, B., D. L. Andress, S. M. Schwartz, D. L. Gillen, S. L. Seliger, P. R. Jadav, D. J. Sherrard and C. Stehman-Breen (2004a). "Survival following parathyroidectomy among United States dialysis patients." Kidney Int 66(5): 2010-2016.
Kestenbaum, B., S. L. Seliger, D. L. Gillen, H. Wasse, B. Young, D. J. Sherrard, N. S. Weiss and C. O. Stehman-Breen (2004b). "Parathyroidectomy rates among United States dialysis patients: 1990-1999." Kidney Int 65(1): 282-288.
Khachigian, L. M. (2016). "Early growth response-1 in the pathogenesis of cardiovascular disease." J Mol Med (Berl) 94(7): 747-753.
Khachigian, L. M., V. Lindner, A. J. Williams and T. Collins (1996). "Egr-1-induced endothelial gene expression: a common theme in vascular injury." Science 271(5254): 1427-1431.
Kidney Disease: Improving Global Outcomes, C. K. D. M. B. D. W. G. (2009). "KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)." Kidney Int Suppl(113): S1-130.
Kinehara, M., S. Kawamura, S. Mimura, M. Suga, A. Hamada, M. Wakabayashi, H. Nikawa and M. K. Furue (2014). "Protein kinase C-induced early growth response protein-1 binding to SNAIL promoter in epithelial-mesenchymal transition of human embryonic stem cells." Stem Cells Dev 23(18): 2180-2189.
Kumbrink, J., M. Gerlinger and J. P. Johnson (2005). "Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop." J Biol Chem 280(52): 42785-42793.
Lafrance, J. P., H. Cardinal, M. Leblanc, F. Madore, V. Pichette, L. Roy and J. Le Lorier (2013). "Effect of cinacalcet availability and formulary listing on parathyroidectomy rate trends." BMC Nephrol 14: 100.
Lee, C. G., S. J. Cho, M. J. Kang, S. P. Chapoval, P. J. Lee, P. W. Noble, T. Yehualaeshet, B. Lu, R. A. Flavell, J. Milbrandt, R. J. Homer and J. A. Elias (2004). "Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis." J Exp Med 200(3): 377-389.
Lee, S. L., Y. Sadovsky, A. H. Swirnoff, J. A. Polish, P. Goda, G. Gavrilina and J. Milbrandt (1996). "Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)." Science 273(5279): 1219-1221.
Lee, S. L., L. C. Tourtellotte, R. L. Wesselschmidt and J. Milbrandt (1995). "Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A." J.Biol.Chem. 270(17): 9971-9977.
Levey, A. S., K. U. Eckardt, Y. Tsukamoto, A. Levin, J. Coresh, J. Rossert, D. De Zeeuw, T. H. Hostetter, N. Lameire and G. Eknoyan (2005). "Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)." Kidney Int 67(6): 2089-2100.
Li, S. W., C. Y. Wang, Y. J. Jou, T. C. Yang, S. H. Huang, L. Wan, Y. J. Lin and C. W. Lin (2016). "SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-beta1 via ROS/p38 MAPK/STAT3 pathway." Sci Rep 6: 25754.
Lin, H. C., C. L. Chen, H. S. Lin, K. J. Chou, H. C. Fang, S. I. Liu, C. Y. Hsu, W. C. Huang, C. W. Huang, C. K. Huang, T. Y. Chang, Y. T. Chang and P. T. Lee (2014). "Parathyroidectomy improves cardiovascular outcome in nondiabetic dialysis patients with secondary hyperparathyroidism." Clin Endocrinol (Oxf) 80(4): 508-515.
Liu, C., E. Adamson and D. Mercola (1996). "Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1." Proceedings of the National Academy of Sciences 93(21): 11831-11836.
Locatelli, F., P. Messa, A. Bellasi, M. Cozzolino, M. Di Luca, G. Garibotto, L. Gesualdo, F. Malberti, C. Massimetti, S. Mazzaferro, M. C. Mereu, M. Morosetti, L. F. Morrone, V. Panuccio, F. Rapisarda, D. Russo and D. Schinella (2013). "What can we learn from a statistically inconclusive trial? Consensus conference on the EVOLVE study results." G Ital Nefrol 30(5): 1-9.
Lohoff, M., M. Giaisi, R. Kohler, B. Casper, P. H. Krammer and M. Li-Weber (2010). "Early growth response protein-1 (Egr-1) is preferentially expressed in T helper type 2 (Th2) cells and is involved in acute transcription of the Th2 cytokine interleukin-4." J Biol Chem 285(3): 1643-1652.
Lorenz, G., M. N. Darisipudi and H. J. Anders (2014). "Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis." Nephrol Dial Transplant 29(1): 41-48.
Malberti, F., D. Marcelli, F. Conte, A. Limido, D. Spotti and F. Locatelli (2001). "Parathyroidectomy in patients on renal replacement therapy: an epidemiologic study." J Am Soc Nephrol 12(6): 1242-1248.
Matheny, C., M. L. Day and J. Milbrandt (1994). "The nuclear localization signal of NGFI-A is located within the zinc finger DNA binding domain." J Biol Chem 269(11): 8176-8181.
McCaffrey, T. A., C. Fu, B. Du, S. Eksinar, K. C. Kent, H. Bush, Jr., K. Kreiger, T. Rosengart, M. I. Cybulsky, E. S. Silverman and T. Collins (2000). "High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis." J Clin Invest 105(5): 653-662.
Meng, Z., C. E. Camalier, D. A. Lucas, T. D. Veenstra, G. R. Beck, Jr. and T. P. Conrads (2006). "Probing early growth response 1 interacting proteins at the active promoter in osteoblast cells using oligoprecipitation and mass spectrometry." J Proteome Res 5(8): 1931-1939.
Milbrandt, J. (1987). "A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor." Science 238(4828): 797-799.
Morgan, J. I. and T. Curran (1989). "Stimulus-transcription coupling in neurons: role of cellular immediate-early genes." Trends Neurosci 12(11): 459-462.
Mou, Z., J. You, Q. Xiao, Y. Wei, J. Yuan, Y. Liu, G. Brewer and W. J. Ma (2012). "HuR posttranscriptionally regulates early growth response-1 (Egr-1) expression at the early stage of T cell activation." FEBS Lett 586(24): 4319-4325.
Nakamura, H., Y. Isaka, M. Tsujie, H. D. Rupprecht, Y. Akagi, N. Ueda, E. Imai and M. Hori (2002). "Introduction of DNA enzyme for Egr-1 into tubulointerstitial fibroblasts by electroporation reduced interstitial alpha-smooth muscle actin expression and fibrosis in unilateral ureteral obstruction (UUO) rats." Gene Ther. 9(8): 495-502.
National Kidney, F. (2003). "K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease." Am J Kidney Dis 42(4 Suppl 3): S1-201.
Okada, M., S. F. Yan and D. J. Pinsky (2002). "Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets." FASEB J 16(14): 1861-1868.
Okuno, S., E. Ishimura, K. Kitatani, Y. Fujino, K. Kohno, Y. Maeno, K. Maekawa, T. Yamakawa, Y. Imanishi, M. Inaba and Y. Nishizawa (2007). "Presence of abdominal aortic calcification is significantly associated with all-cause and cardiovascular mortality in maintenance hemodialysis patients." Am J Kidney Dis 49(3): 417-425.
Pagel, J. I. and E. Deindl (2011). "Early growth response 1--a transcription factor in the crossfire of signal transduction cascades." Indian J Biochem Biophys 48(4): 226-235.
Palmer, S. C., S. Gardner, M. Tonelli, D. Mavridis, D. W. Johnson, J. C. Craig, R. French, M. Ruospo and G. F. Strippoli (2016). "Phosphate-Binding Agents in Adults With CKD: A Network Meta-analysis of Randomized Trials." Am J Kidney Dis 68(5): 691-702.
Palmer, S. C., I. Nistor, J. C. Craig, F. Pellegrini, P. Messa, M. Tonelli, A. Covic and G. F. Strippoli (2013). "Cinacalcet in patients with chronic kidney disease: a cumulative meta-analysis of randomized controlled trials." PLoS Med 10(4): e1001436.
Parra, E., J. Ferreira and A. Ortega (2011). "Overexpression of EGR-1 modulates the activity of NF-kappaB and AP-1 in prostate carcinoma PC-3 and LNCaP cell lines." Int J Oncol 39(2): 345-352.
Poirier, R., H. Cheval, C. Mailhes, P. Charnay, S. Davis and S. Laroche (2007). "Paradoxical role of an Egr transcription factor family member, Egr2/Krox20, in learning and memory." Front Behav Neurosci 1: 6.
Press, T., S. Viale-Bouroncle, O. Felthaus, M. Gosau and C. Morsczeck (2015). "EGR1 supports the osteogenic differentiation of dental stem cells." Int Endod J 48(2): 185-192.
Prince, J. M., M. J. Ming, R. M. Levy, S. Liu, D. J. Pinsky, Y. Vodovotz and T. R. Billiar (2007). "Early growth response 1 mediates the systemic and hepatic inflammatory response initiated by hemorrhagic shock." Shock 27(2): 157-164.
Pritchard, M. T. and L. E. Nagy (2010). "Hepatic fibrosis is enhanced and accompanied by robust oval cell activation after chronic carbon tetrachloride administration to Egr-1-deficient mice." Am J Pathol 176(6): 2743-2752.
Raggi, P. and M. Kleerekoper (2008). "Contribution of bone and mineral abnormalities to cardiovascular disease in patients with chronic kidney disease." Clin J Am Soc Nephrol 3(3): 836-843.
Ramana, C. V., G. S. Cheng, A. Kumar, H. J. Kwon and R. I. Enelow (2009). "Role of alveolar epithelial early growth response-1 (Egr-1) in CD8+ T cell-mediated lung injury." Mol Immunol 47(2-3): 623-631.
Rayner, B. S., G. A. Figtree, T. Sabaretnam, P. Shang, J. Mazhar, J. C. Weaver, W. N. Lay, P. K. Witting, S. N. Hunyor, S. M. Grieve, L. M. Khachigian and R. Bhindi (2013). "Selective inhibition of the master regulator transcription factor Egr-1 with catalytic oligonucleotides reduces myocardial injury and improves left ventricular systolic function in a preclinical model of myocardial infarction." J Am Heart Assoc 2(4): e000023.
Reumann, M. K., O. Strachna, S. Yagerman, D. Torrecilla, J. Kim, S. B. Doty, L. Lukashova, A. L. Boskey and P. Mayer-Kuckuk (2011). "Loss of transcription factor early growth response gene 1 results in impaired endochondral bone repair." Bone 49(4): 743-752.
Ronski, K., M. Sanders, J. A. Burleson, V. Moyo, P. Benn and M. Fang (2005). "Early growth response gene 1 (EGR1) is deleted in estrogen receptor-negative human breast carcinoma." Cancer 104(5): 925-930.
Rupprecht, H. D., G. Hoffer, E. de Heer, R. B. Sterzel, G. Faller and H. O. Schoecklmann (1997). "Expression of the transcriptional regulator Egr-1 in experimental glomerulonephritis: requirement for mesangial cell proliferation." Kidney Int 51(3): 694-702.
Russo, M. W., B. R. Sevetson and J. Milbrandt (1995). "Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription." Proc Natl Acad Sci U S A 92(15): 6873-6877.
Safford, M., S. Collins, M. A. Lutz, A. Allen, C. T. Huang, J. Kowalski, A. Blackford, M. R. Horton, C. Drake, R. H. Schwartz and J. D. Powell (2005). "Egr-2 and Egr-3 are negative regulators of T cell activation." Nat Immunol 6(5): 472-480.
Sanz, A. B., M. D. Sanchez-Nino, A. M. Ramos, J. A. Moreno, B. Santamaria, M. Ruiz-Ortega, J. Egido and A. Ortiz (2010). "NF-kappaB in renal inflammation." J Am Soc Nephrol 21(8): 1254-1262.
Schneider-Maunoury, S., P. Topilko, T. Seitandou, G. Levi, M. Cohen-Tannoudji, S. Pournin, C. Babinet and P. Charnay (1993). "Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain." Cell 75(6): 1199-1214.
Sela, U., M. Dayan, R. Hershkoviz, O. Lider and E. Mozes (2008). "A peptide that ameliorates lupus up-regulates the diminished expression of early growth response factors 2 and 3." J Immunol 180(3): 1584-1591.
Sharma, J., P. Raggi, N. Kutner, J. Bailey, R. Zhang, Y. Huang, C. A. Herzog and C. Weber (2012). "Improved long-term survival of dialysis patients after near-total parathyroidectomy." J Am Coll Surg 214(4): 400-407; discussion 407-408.
Shigeoka, A. A., J. L. Mueller, A. Kambo, J. C. Mathison, A. J. King, W. F. Hall, S. Correia Jda, R. J. Ulevitch, H. M. Hoffman and D. B. McKay (2010). "An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury." J Immunol 185(10): 6277-6285.
Shimoyamada, H., T. Yazawa, H. Sato, K. Okudela, J. Ishii, M. Sakaeda, K. Kashiwagi, T. Suzuki, H. Mitsui, T. Woo, M. Tajiri, T. Ohmori, T. Ogura, M. Masuda, H. Oshiro and H. Kitamura (2010). "Early growth response-1 induces and enhances vascular endothelial growth factor-A expression in lung cancer cells." Am J Pathol 177(1): 70-83.
Shin, I. S., J. M. Kim, K. L. Kim, S. Y. Jang, E. S. Jeon, S. H. Choi, D. K. Kim, W. Suh and Y. W. Kim (2009). "Early growth response factor-1 is associated with intraluminal thrombus formation in human abdominal aortic aneurysm." J Am Coll Cardiol 53(9): 792-799.
Shin, S. Y., J. M. Lee, Y. Lim and Y. H. Lee (2013). "Transcriptional regulation of the growth-regulated oncogene alpha gene by early growth response protein-1 in response to tumor necrosis factor alpha stimulation." Biochim Biophys Acta 1829(10): 1066-1074.
Simon, P., K. Schott, R. W. Williams and F. Schaeffel (2004). "Posttranscriptional regulation of the immediate-early gene EGR1 by light in the mouse retina." Eur J Neurosci 20(12): 3371-3377.
Singha, B., H. R. Gatla, S. Manna, T. P. Chang, S. Sanacora, V. Poltoratsky, A. Vancura and I. Vancurova (2014). "Proteasome inhibition increases recruitment of IkappaB kinase beta (IKKbeta), S536P-p65, and transcription factor EGR1 to interleukin-8 (IL-8) promoter, resulting in increased IL-8 production in ovarian cancer cells." J Biol Chem 289(5): 2687-2700.
Skerka, C., E. L. Decker and P. F. Zipfel (1995). "A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1." J Biol Chem 270(38): 22500-22506.
Slinin, Y., R. N. Foley and A. J. Collins (2007). "Clinical epidemiology of parathyroidectomy in hemodialysis patients: the USRDS waves 1, 3, and 4 study." Hemodial Int 11(1): 62-71.
Srinivasan, R., G. M. Mager, R. M. Ward, J. Mayer and J. Svaren (2006). "NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex." J Biol Chem 281(22): 15129-15137.
Suissa, S. (2008). "Immortal time bias in pharmaco-epidemiology." Am J Epidemiol 167(4): 492-499.
Sukhatme, V. P. (1990). "Early transcriptional events in cell growth: the Egr family." J Am Soc Nephrol 1(6): 859-866.
Sukhatme, V. P., S. Kartha, F. G. Toback, R. Taub, R. G. Hoover and C. H. Tsai-Morris (1987). "A novel early growth response gene rapidly induced by fibroblast, epithelial cell and lymphocyte mitogens." Oncogene Res 1(4): 343-355.
Sun, S., X. Ning, Y. Zhai, R. Du, Y. Lu, L. He, R. Li, W. Wu, W. Sun and H. Wang (2014). "Egr-1 mediates chronic hypoxia-induced renal interstitial fibrosis via the PKC/ERK pathway." Am J Nephrol 39(5): 436-448.
Svaren, J., B. R. Sevetson, E. D. Apel, D. B. Zimonjic, N. C. Popescu and J. Milbrandt (1996). "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli." Mol Cell Biol 16(7): 3545-3553.
Tamura, M., R. Aizawa, M. Hori and H. Ozaki (2009). "Progressive renal dysfunction and macrophage infiltration in interstitial fibrosis in an adenine-induced tubulointerstitial nephritis mouse model." Histochem Cell Biol 131(4): 483-490.
Tang, M. J. and R. L. Tannen (1990). "Relationship between proliferation and glucose metabolism in primary cultures of rabbit proximal tubules." Am J Physiol 259(3 Pt 1): C455-461.
Tentori, F., J. M. Albert, E. W. Young, M. J. Blayney, B. M. Robinson, R. L. Pisoni, T. Akiba, R. N. Greenwood, N. Kimata, N. W. Levin, L. M. Piera, R. Saran, R. A. Wolfe and F. K. Port (2009). "The survival advantage for haemodialysis patients taking vitamin D is questioned: findings from the Dialysis Outcomes and Practice Patterns Study." Nephrol Dial Transplant 24(3): 963-972.
Topilko, P., S. Schneider-Maunoury, G. Levi, A. Baron-Van Evercooren, A. B. Chennoufi, T. Seitanidou, C. Babinet and P. Charnay (1994). "Krox-20 controls myelination in the peripheral nervous system." Nature 371(6500): 796-799.
Tourtellotte, W. G. and J. Milbrandt (1998). "Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3." Nat Genet 20(1): 87-91.
Tourtellotte, W. G., R. Nagarajan, A. Auyeung, C. Mueller and J. Milbrandt (1999). "Infertility associated with incomplete spermatogenic arrest and oligozoospermia in Egr4-deficient mice." Development 126(22): 5061-5071.
Trombetti, A., C. Stoermann, J. H. Robert, F. R. Herrmann, P. Pennisi, P. Y. Martin and R. Rizzoli (2007). "Survival after parathyroidectomy in patients with end-stage renal disease and severe hyperparathyroidism." World J Surg 31(5): 1014-1021.
Vedantham, S., D. Thiagarajan, R. Ananthakrishnan, L. Wang, R. Rosario, Y. S. Zou, I. Goldberg, S. F. Yan, A. M. Schmidt and R. Ramasamy (2014). "Aldose reductase drives hyperacetylation of Egr-1 in hyperglycemia and consequent upregulation of proinflammatory and prothrombotic signals." Diabetes 63(2): 761-774.
Verbeke, F., W. Van Biesen, E. Honkanen, B. Wikstrom, P. B. Jensen, J. M. Krzesinski, M. Rasmussen, R. Vanholder, P. L. Rensma and C. S. Investigators (2011). "Prognostic value of aortic stiffness and calcification for cardiovascular events and mortality in dialysis patients: outcome of the calcification outcome in renal disease (CORD) study." Clin J Am Soc Nephrol 6(1): 153-159.
Viale-Bouroncle, S., C. Klingelhoffer, T. Ettl and C. Morsczeck (2015). "The AKT signaling pathway sustains the osteogenic differentiation in human dental follicle cells." Mol Cell Biochem 406(1-2): 199-204.
Wan, H., Y. Yuan, J. Liu and G. Chen (2012). "Pioglitazone, a PPAR-gamma activator, attenuates the severity of cerulein-induced acute pancreatitis by modulating early growth response-1 transcription factor." Transl Res 160(2): 153-161.
Wang, H. H., S. Y. Hung, J. M. Sung, K. Y. Hung and J. D. Wang (2014). "Risk of stroke in long-term dialysis patients compared with the general population." Am J Kidney Dis 63(4): 604-611.
Warner, L. E., J. Svaren, J. Milbrandt and J. R. Lupski (1999). "Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies." Hum Mol Genet 8(7): 1245-1251.
Waters, C. M., D. C. Hancock and G. I. Evan (1990). "Identification and characterisation of the egr-1 gene product as an inducible, short-lived, nuclear phosphoprotein." Oncogene 5(5): 669-674.
Wen, C. P., T. Y. Cheng, M. K. Tsai, Y. C. Chang, H. T. Chan, S. P. Tsai, P. H. Chiang, C. C. Hsu, P. K. Sung, Y. H. Hsu and S. F. Wen (2008). "All-cause mortality attributable to chronic kidney disease: a prospective cohort study based on 462 293 adults in Taiwan." Lancet 371(9631): 2173-2182.
Wilkinson, D. G., S. Bhatt, P. Chavrier, R. Bravo and P. Charnay (1989). "Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse." Nature 337(6206): 461-464.
Wu, M., D. S. Melichian, E. Chang, M. Warner-Blankenship, A. K. Ghosh and J. Varga (2009a). "Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma." Am J Pathol 174(2): 519-533.
Wu, M., D. S. Melichian, M. de la Garza, K. Gruner, S. Bhattacharyya, L. Barr, A. Nair, S. Shahrara, P. H. Sporn, T. A. Mustoe, W. G. Tourtellotte and J. Varga (2009b). "Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healing." Am J Pathol 175(3): 1041-1055.
Yamada, K., D. J. Gerber, Y. Iwayama, T. Ohnishi, H. Ohba, T. Toyota, J. Aruga, Y. Minabe, S. Tonegawa and T. Yoshikawa (2007). "Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia." Proc Natl Acad Sci U S A 104(8): 2815-2820.
Yamamoto, S., M. Yamane, O. Yoshida, N. Waki, M. Okazaki, A. Matsukawa, T. Oto and S. Miyoshi (2015). "Early Growth Response-1 Plays an Important Role in Ischemia-Reperfusion Injury in Lung Transplants by Regulating Polymorphonuclear Neutrophil Infiltration." Transplantation 99(11): 2285-2293.
Yan, S. F., T. Fujita, J. Lu, K. Okada, Y. Shan Zou, N. Mackman, D. J. Pinsky and D. M. Stern (2000). "Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress." Nat Med 6(12): 1355-1361.
Yao, J., N. Mackman, T. S. Edgington and S. T. Fan (1997). "Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors." J Biol Chem 272(28): 17795-17801.
Zhu, B., A. L. Symonds, J. E. Martin, D. Kioussis, D. C. Wraith, S. Li and P. Wang (2008). "Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease." J Exp Med 205(10): 2295-2307.
Zipfel, P. F., E. L. Decker, C. Holst and C. Skerka (1997). "The human zinc finger protein EGR-4 acts as autoregulatory transcriptional repressor." Biochim Biophys Acta 1354(2): 134-144.
論文全文使用權限
  • 同意授權校內瀏覽/列印電子全文服務,於2017-09-29起公開。
  • 同意授權校外瀏覽/列印電子全文服務,於2017-09-29起公開。


  • 如您有疑問,請聯絡圖書館
    聯絡電話:(06)2757575#65773
    聯絡E-mail:etds@email.ncku.edu.tw