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系統識別號 U0026-2108201400510100
論文名稱(中文) 利用有限元素模型評估不同再窄化時期靜脈移植處的流態
論文名稱(英文) Using finite element model to estimate vein graft flow pattern during different stages of restenosis
校院名稱 成功大學
系所名稱(中) 生物醫學工程學系
系所名稱(英) Department of BioMedical Engineering
學年度 102
學期 2
出版年 103
研究生(中文) 王紹宇
研究生(英文) Shao-Yu Wang
學號 P86011058
學位類別 碩士
語文別 中文
論文頁數 72頁
口試委員 指導教授-蘇芳慶
指導教授-吳佳慶
口試委員-張志涵
口試委員-王士豪
中文關鍵字 靜脈移植  計算流體力學  高頻超音波  有限元素模擬 
英文關鍵字 Vein graft  Computational fluid dynamics  High frequency ultrasound  Finite element simulation 
學科別分類
中文摘要 靜脈移植手術是臨床上最常見治療動脈阻塞相關疾病的方法之一,然而,在靜脈移植手術後,血管經常會發生再窄化的情形,這也是臨床最常見使靜脈移植手術失敗的原因。計算流體力學可以提供許多手術後血管的相關資訊,協助臨床預測可能會發生再窄化的區域。本研究中靜脈移植手術是利用外頸靜脈置換大鼠的頸總動脈,並使用30 MHz的高頻超音波系統觀察,在手術後的不同時間點,血管結構上改變。後續將藉由MATLAB軟體,從高頻超音波影像中重建不同時間點血管的3D幾何模型,並且利用有限元素法結合流固耦合的概念,模擬流力場與固力場相關的力學參數。血管管壁的剪切應力與流速將透過牛頓流體計算,血管管徑與壓力對管壁的影響將藉由此模形進行模擬。目前研究結果顯示,當血管管徑變小時,將會導致血管壁的剪切應力與流速增加,同時在靜脈移植區段可以發現最大的變形量與蒙麥斯應力產生,並且在手術兩周之後,血管再窄化的情況更加嚴重。綜合以上,結合高頻超音波系統與有限元素法進行流固耦合的模擬,能夠成功預測血流動力學因素引起的病理機制。
英文摘要 Restenosis usually occurs after patients underwent vein graft bypass surgery which is the common failure for vascular remodeling. Computational fluid dynamics (CFD) simulations can provide lots of important information of graft after surgery which can help to predict the occurrence of restenosis. In current study, the vein graft bypass surgery was created by replacing the common carotid artery with the external jugular vein in SD rats. The 30 MHz high frequency ultrasound (HFU) system was used to monitor the dynamic changes in vessel structures in vivo at different time points after surgery. Three dimensional geometry of vessel at different time points were reconstructed by HFU images using MATLAB. The mechanical properties of flow field and static structure field can be predicted with the application of fluid-structure interactive (FSI) finite element model. The shear stress on the vessel walls was directly calculated for Newtonian stress description and velocity field. The impacts of variations in vessel radii and pressure on vessel walls were predicted in this hemodynamic model. Our results showed decreases of the lumen area at the downstream of suture junction which lead to the increased of wall shear stress and velocity. And both of the maximum deformation and von-Mises stress could be observed in the vein graft segment. After two weeks of surgery, the narrowing of vein graft initiated seriously progresses of pathological remodeling. In summary, the combination of HFU imaging system and finite element methods for fluid-structure interactive estimation may predict the pathological mechanisms triggered by hemodynamic factors.
論文目次 中文摘要 II
致謝 VII
目錄 VIII
圖目錄 XI
表目錄 XIV
第一章 前言 (Introduction) 1
1.1 心血管疾病 (Cardiovascular disease) 1
1.2臨床動脈粥樣硬化之治療方法 (Clinical treatments for atherosclerosis) 2
1.3 靜脈移植再窄化之可能因子 (Possible reasons of vein graft restenosis) 4
1.3.1 動靜脈之解剖構造差異 (Anatomical structural differences between artery and vein) 6
1.3.2動靜脈之管壁機械性質差異 (Mechanical property differences between artery and vein) 8
1.3.3 動靜脈之流體性質差異 (Fluid property differences between artery and vein) 9
1.4 非侵入式早期診斷醫療器材: 高頻超音波系統(High frequency ultrasound (HFU) system) 10
1.5 數值方法輔助之血管重塑模擬:計算流體力學(Computational fluid dynamics, CFD) 11
研究假說 (Hypothesis) 15
研究目的 (Specific aims) 16
第二章 材料與方法 (Materials and Methods) 17
2.1 實驗流程圖 (Experimental flow chart) 17
2.2 動物模型(Animal models) 19
2.3 高頻超音波掃描 (HFU scanning) 20
2.4 高頻超音波影像重建3D 血管模型 (3D model reconstruction by HFU images) 21
2.4.1 高頻超音波影像之前處理 (Pre-processing of HFU images) 21
2.4.2 3D 模型重建 (3D model reconstruction) 23
2.4.3 3D模型的後處理 (Post-processing of 3D model) 23
2.5 獲取流力場之邊界條件 (Flow field boundary condition acquisition) 24
2.5.1 血流流速 (Flow velocity) 24
2.6 有限元素之血流流力場模擬 (Finite element simulation of blood flow field) 26
2.6.1 血流流力場之收斂性測試 (Convergence tests of blood flow field) 26
2.6.2 流力場之邊界條件設定 (Boundary condition setting of flow field) 27
2.6.3 ANSYS CFX模組之求解器 (Solver of ANSYS CFX module) 28
2.7 獲取結構場場之邊界條件 (Vessel structure boundary condition acquisition) 28
2.7.1 楊氏模數 (Young’s modulus) 28
2.8有限元素之血管結構場模擬 (Finite element simulation of vessel structure) 30
2.8.1血管結構場之收斂性測試 (Convergence tests of blood vessel structure) 30
2.8.2結構場之邊界條件設定 (Boundary condition setting of vessel structure) 31
2.8.3 ANSYS static structural模組之求解器 (Solver of ANSYS static structural module) 32
第三章 結果 (Results) 33
3.1血管幾何之週數變化 33
3.2有限元素模型之收斂性測試結果 39
3.2.1血流流力場之收斂性測試結果 39
3.2.2血管結構場之收斂性測試結果 40
3.3血流流力場分析結果 41
3.3.1 流速模擬結果分析 41
3.3.2 壁剪應力模擬結果分析 46
3.4血管AFM之材料測試結果 48
3.5 血管結構場分析結果 49
3.5.1 變形量模擬結果分析 49
3.5.2 蒙麥斯應力 (von-Mises stress)模擬結果分析 53
3.6 再窄化高風險區域預測 57
第四章 討論 (Discussion) 59
第五章 結論 (Conclusion) 66
參考資料 (Reference) 68
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