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系統識別號 U0026-2008202018073400
論文名稱(中文) 超快速超音波向量流速量測應用於人類股動脈管壁剪應力成像
論文名稱(英文) Wall Shear Stress Imaging for Human Femoral Artery Based on Ultrafast Ultrasound Vector Velocity Estimation
校院名稱 成功大學
系所名稱(中) 生物醫學工程學系
系所名稱(英) Department of BioMedical Engineering
學年度 108
學期 2
出版年 109
研究生(中文) 王一傑
研究生(英文) I-Chieh Wang
學號 P86074137
學位類別 碩士
語文別 英文
論文頁數 47頁
口試委員 指導教授-黃執中
召集委員-劉秉彥
口試委員-李夢麟
召集委員-張瑋婷
中文關鍵字 周邊血管疾病  壁面剪應力成像  超快速超音波成像  向量都普勒流速量測 
英文關鍵字 Peripheral artery disease  Wall shear stress imaging  Ultrafast ultrasound  Vector Doppler velocity estimation 
學科別分類
中文摘要 周邊血管疾病作為一種主要的血管疾病,然而在疾病的初期,症狀的展現並不明顯。因此若能夠利用非侵入的方式及時地得到區域性的血管內參數,對於早期的篩檢與治療會有明顯的幫助。壁面剪應力是由流動的血液對血管壁施加的一種應力,並且被認為是影響血液動力學的一項重要參數。過高的壁面剪應力可能導致內皮細胞的受損、斑塊或動脈瘤的破裂等。目前活體內量測管壁剪應力的方式仍然存在許多問題,如:僅能取得固定位置的平均數值,然而壁面剪應力乃是一個隨時間變化的數值。因此,能在活體內得到動態的壁面剪應力資訊的方式是必要的。
在本論文提出了基於超音波向量都普勒影像技術,用於量測活體內股動脈的壁面剪應力。本仿體實驗中,透過不同流速的流管驗證了此技術應用在壁面剪應力上的效果。實驗結果顯示,在不同流速下仿體的收縮期平均管壁剪應力分別是0.55 pa、0.70 pa、0.86 pa。並且設計了一個窄化的仿體以了解壁面剪應力在不對稱管內的分布情形。相對高的壁面剪應力出現在窄化處而相對低的管壁剪應力則出現在窄化的下游地區。在人體實驗中,壁面剪應力影像成功應用在股動脈分岔處,並且得到在股總動脈、股淺動脈、股深動脈的平均壁面剪應力分別為0.41 pa、0.49 pa、0.26 pa。
在本論文中,提出了一種基於超音波向量都普勒的壁面剪應力成像技術,並且成功應用在人體的股動脈量測。
英文摘要 Peripheral vascular disease (PAD) is a major vascular disease. However, the symptoms of PAD are not obvious at the early stage. Therefore, if the intravascular parameters can be obtained in time, it means a significant for early diagnosis and treatment. Wall shear stress is a kind of friction exerted on the artery wall by the flowing blood, which has been considered as an important parameter in hemodynamics. Excessively high WSS may cause endothelial cell damage, plaque or aneurysm rupture, etc. At present, there are still many problems in measuring the wall shear stress in vivo. For example, only the average value at a fixed position can be obtained, but the WSS is a value that changes with time. Therefore, it is necessary to obtain dynamic wall shear stress information in vivo.
In this study, WSS imaging based on ultrasound vector Doppler velocity estimation was proposed to measure the femoral artery in vivo. In the phantom experiments, the reliability was verified to straight phantom with three different flow velocity. The experimental results show that the average systole WSS of the straight phantom at different flow velocity is 0.55 pa, 0.70 pa, and 0.86 pa, respectively. Moreover, a stenosis phantom has been designed to understand the distribution of non-regular vessel. The relatively high WSS are obtained at the narrowed compare with straight parts of the stenosis phantom. In in vivo experiments, the WSS image was successfully applied to the bifurcation of the femoral artery, and the average systole WSS in the common femoral artery, superficial femoral artery, and deep femoral artery were 0.41 pa, 0.49 pa, and 0.26 pa, respectively.
In this paper, Technique of WSS imaging based on ultrasound vector velocity estimation was proposed, and successfully applied to measure for the human femoral artery.
論文目次 摘要...II
Abstract...III
誌謝...IV
Contents...V
List of Tables...VII
List of Figures...VIII
Chapter 1 Introduction...1
1.1 Peripheral Arterial Disease...1
1.2 Femoral Artery...3
1.3 Wall Shear Stress...4
1.4 Motivation and Purpose...7
Chapter 2 Theoretical Foundations...8
2.1 Ultrasound...8
2.1.1 Fundamental Theory...8
2.1.2 Reflection, Refraction and Attenuation...9
2.1.3 Doppler Effect...11
2.2 Ultrasound Imaging...12
2.2.1 A-Mode Imaging...13
2.2.2 B-Mode Imaging...13
2.2.3 M-Mode Imaging...14
2.3 Ultrafast Ultrasound Imaging...15
2.3.1 Plane-Wave Imaging...15
2.3.2 Coherent Plane-Wave compounding...16
2.3.3 Doppler Imaging...17
Chapter 3 Materials and Methods...19
3.1 Experimental Setup and Data Acquisition...19
3.2 Data Processing...21
3.2.1 Particle Enhance Imaging...21
3.2.2 Vector Velocity Estimation...22
3.2.3 Wall Shear Rate Estimation...24
3.2.4 Wall Shear Stress Imaging...25
3.3 In Vitro Phantom Study...26
3.3.1 The Setup of Flow Phantom...26
3.3.2 Straight Phantom under Slow, Medium and Fast Flow...26
3.3.3 Stenosis Phantom...28
3.4 In Vivo Study...28
Chapter 4 Results...29
4.1 In Vitro Phantom Study...29
4.1.1 Straight Phantom...29
4.1.2 Stenosis Phantom...32
4.2 In Vivo Study...34
Chapter 5 Discussion...37
Chapter 6 Conclusion...40
Chapter 7 Future Work...41
References...42
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