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系統識別號 U0026-2008201316274900
論文名稱(中文) 建構一套新型雙極性脈衝激發器於高頻超音波影像系統之應用
論文名稱(英文) Development of a Novel Bipolar Pulse Generator for High Frequency Ultrasound Imaging System
校院名稱 成功大學
系所名稱(中) 生物醫學工程學系
系所名稱(英) Department of BioMedical Engineering
學年度 101
學期 2
出版年 102
研究生(中文) 章哲瑋
研究生(英文) Che-Wei Chang
學號 P86004124
學位類別 碩士
語文別 英文
論文頁數 54頁
口試委員 指導教授-陳天送
口試委員-陳培展
口試委員-陳永福
口試委員-林家宏
中文關鍵字 高頻超音波  雙極性脈衝激發器  脈衝調變  手部血管影像 
英文關鍵字 high frequency ultrasound  bipolar pulse generator  Pulse width modulation  vascular image of hand 
學科別分類
中文摘要 超音波影像系統具有非侵入性與即時成像的優點,被廣泛的應用在醫學診斷上。近年來,高頻超音波被廣泛的研究,因為高頻超音波影像系統具有較高的解析度,能夠觀察表淺細微的物體,例如:血管、眼球、皮膚及小動物組織等。高頻超音波影像系統的解析度跟超音波激發器相關,超音波激發器的好壞會影響到影像的解析度。目前,高頻超音波激發器多為商用儀器,商用儀器價格昂貴、體積龐大及大多為單極性脈衝形式且脈衝頻率無法任意改變。商用超音波激發器無法達到50 MHz探頭的中心頻率,使得影像解析度下降。本研究發展一套新型雙極性脈衝激發器,具有體積小、低成本、高電壓、低雜訊的特性,雙極性脈衝激發器可以自行調整脈衝的中心頻率、脈衝重複週期及高電壓可以選擇±50 V& ±100 V。測試結果與商用儀器5900PR進行比較。回波訊號的頻譜分析顯示脈衝的中心頻率接近50 MHz與探頭的中心頻率接近,影像的橫向解析度從100 μm提高到60 μm。在B-mode跟C-mode的影像模式比較下,顯示影像品質的提升,其銳利度及清晰度都有明顯的提升。在手部血管影像實驗裡,量測血管在不同溫度下的變化,顯示正常人與糖尿病患者有明顯的差異,可反映出糖尿病患的病情。高頻超音波影像系統解析度的提升,能夠在生物研究及醫學研究上提供更多有用的資訊。
英文摘要 High frequency ultrasound imaging system has non-invasive and real-time characteristics, so it is widely used in medical diagnosis. High frequency ultrasound system with high resolution has been widely studied in recent years. It is able to observe superficial object such as blood vessels, eyes, skin and small animal tissues. The resolution of high frequency ultrasound system is highly dependent on ultrasound pulser. Recently, the commercial available ultrasound pulser is very expensive with low bandwidth. It is unipolar (negative) pulse and the frequency of pulse cannot be adjustable. The center frequency of pulser does not obtain the center frequency of 50 MHz transducer, reducing the image resolution. This study developed a novel bipolar pulse generator that has small size, low cost, high voltage and low noise, it can adjust the frequency of the pulse, the pulse repetition frequency and can select high voltage ±50 V & ±100 V. The results of test are compared with commercial instrument 5900PR. The center frequency of bipolar pulse is close to the center frequency of 50 MHz transducer. The image of lateral resolution improved from 100 μm to 60 μm. The quality of image was improved in the B-mode and C-mode image, its sharpness and clarity has noticeably improved. In the vascular image of hand, we measured the vascular changes at different temperatures. It showed that normal subject and diabetes patient have significant difference and can reflect the diabetes patient's condition. The resolution of high frequency ultrasound imaging system improved, it can provide more useful information in the biological research and medical diagnosis.
論文目次 摘要 I
ABSTRACT II
誌謝 III
CONTENT IV
TABLES VI
FIGURES VII
CHAPTER 1 INTRODUCTION 1
1.1 Motivation and Objectives 1
1.2 Literatures Review 2
1.3 Applications of High Frequency Ultrasound Imaging System 5
1.4 Diabetes Foot 11
1.4.1 Peripheral Neuropathy 11
1.4.2 Peripheral Vascular Lesion 13
1.4.3 Infections 13
CHAPTER 2 THEORETICAL Development 14
2.1 Introduction of High Frequency Ultrasound Imaging 14
2.1.1 Transducers 14
2.1.2 The Resolution of High Frequency Ultrasound Imaging 15
2.1.3 The Imaging Theory of Ultrasound 17
2.2 Scan Mode of Ultrasound Imaging 18
2.2.1 A-mode (Amplitude Mode) 19
2.2.2 B-mode (Brightness Mode) 20
2.2.3 C-mode (Constant Depth Mode) 21
CHAPTER 3 PULSER DESIGN 22
3.1 Pulser Description 22
3.2 FPGA 23
3.3 MOSFET Driver 27
3.4 Power MOSFET 30
3.5 Expander & Limiter 31
3.6 Power Supply 32
3.7 System Description 35
Chapter 4 Results and Discussion 37
4.1 Tests of Pulser Output 37
4.2 Test and Comparison of Echo Signals 40
4.3 Comparison of Images in High Frequency Ultrasound Imaging System 44
4.4 The Vascular Area of Hand 46
Chapter 5 Conclusions 51
References 53
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