系統識別號 U0026-1908201301031900
論文名稱(中文) 運用脈聲儀測得之心跳變異率以研究睡眠障礙
論文名稱(英文) A Study of Sleep Disorder Based on the Heart Rate Variability Measured by an Audiocardiography System
校院名稱 成功大學
系所名稱(中) 航空太空工程學系碩博士班
系所名稱(英) Department of Aeronautics & Astronautics
學年度 101
學期 2
出版年 102
研究生(中文) 楊學翰
研究生(英文) Syue-Han Yang
學號 P46001437
學位類別 碩士
語文別 英文
論文頁數 64頁
口試委員 指導教授-尤芳忞
中文關鍵字 脈聲儀系統  能量頻譜密度  潘凱圖  心跳變異率  長期失眠  睡眠呼吸中止症  夜間額葉癲癇 
英文關鍵字 Audiocardiography system  PSD  Poincaré plot  HRV  chronic insomnia  sleep apnea  nocturnal frontal lobe epilepsy 
中文摘要 脈聲儀系統是由血流動力學理論發展而來,利用微型麥克風偵測並記錄手腕橈動脈上的脈波訊號變化,此訊號包含了血流動力學中任何動態壓力變化的訊息,所以使用脈聲儀作為訊號蒐集裝置。睡眠障礙可能導致罹患心血管疾病。本研究使用能量頻譜密度及潘凱圖及分析三組有睡眠障礙的病人。第一組為13位慢性失眠病人及14位正常對照,能量頻譜密度圖顯示慢性失眠病人副交感神經活躍。潘凱圖顯示慢性失眠病人心跳變異率較低,圖形長軸與短軸比值接近1。第二、三組分別是18位睡眠呼吸中止症病人和15位夜間額葉癲癇病人,能量頻譜圖以及潘凱圖都顯示出有上述兩種病患呈現在有壓力的生理狀態,而導致無法有效睡眠。
英文摘要 The Audiocardiography system is developed from hemodynamics theory. It measuring and recording the pulse wave on the wrist artery which contains various cardiovascular system information. The sleep disorders can put people at risk for cardiovascular diseases. Poincare’ plot analysis is a powerful method to analyze non-linear dynamic system and to observe hidden characters. This research collects data through a non-invasive audiocardiography system proposed by Dr. Yu. In this thesis, data from three groups of participants are collected, and power spectral density (PSD) and Poincare’ plot are adopted to analyze the sleep disorder. Group one is a total of 13 non-medicated patients with chronic insomnia and 14 matched controls without insomnia. The analysis result shows that heart rate variability (HRV) is lower and parasympathetic nerves are activated in patients with chronic insomnia. The Poincaré plot index of SD2/SD1for patients with the chronic insomnia shows that it is much lower than which for the matched controls. This result reveals that adaptability of heart in patients with the chronic insomnia is not good enough during daytime. Group two and group three are 18 patients with sleep apnea and 15 patients with nocturnal frontal lobe epilepsy respectively. The results represent that their heart activity are highly alerted for their adaptivity and can not fall into sleep effectively due to the sleep disorder .
論文目次 摘要 I
Abstract II
誌謝 IV
Contents V
Table Contents VIII
Figure contents IX
Symbols XI
中文主文題要 XIII
第一章 緒論 XIII
第二章 理論分析 XIV
第三章 實驗設備、方法與步驟 XV
第四章 結果與討論 XVI
第五章 結論與建議 XVII
Chapter 1 Introduction 1
1-1 Preface 1
1-2 Motivation 2
1-3 Introduction of HRV and Sleep Disorder 4
1-3-1 Heart rate variability 4
1-3-2 Sleep Disorder 6
Chapter 2 Theoretical Analysis 9
2-1 Fast Fourier Transform (FFT) 9
2-2 Heart physiological structure and its current conduction process 11
2-3 HRV analysis 13
2-3-1 Time domain analysis 13
2-3-2 Frequency domain analysis 15
2-3-3 Poincaré plot non-linear analysis 18
2-4 Window technique 19
Chapter 3 Experimental apparatus, Methods and Procedures 22
3-1 Experimental apparatus 22
3-2 Experimental methods and procedures 23
3-2-1 Chronic insomnia 25
3-2-2 Sleep apnea 25
3-2-2 Nocturnal frontal lobe epilepsy 26
3-3 Validation of condenser microphone 27
Chapter 4 Results and Discussion 29
4-1 Validation of microphone frequency response 29
4-2 Analysis of patients with the chronic insomnia 30
4-3 Analysis of patients with sleep apnea 32
4-4 Analysis of patients with the nocturnal frontal lobe epilepsy 34
Chapter 5 Conclusion and Suggestion 36
5-1 Conclusions 36
5-2 Suggestion 37
References 39
Vita 64

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