||Application of Finite Element modeling and Optical
Coherence Tomography to Bioviscoelasticity of
Ultra-structure of Peripheral Nerve
||Department of Mechanical Engineering
peripheral nerve tissues
inverse finite element analysis
Optical Coherence Tomography
The nervous system plays an important role in human body such that, nerve injuries due to trauma or diseases can affect our daily life. Many studies have been devoted to the histology, pathology and electroneurophysiology of the nerve, but only few studies focused on its mechanical properties.
In this thesis, the mechanical characteristics of sciatic nervers of rats were investigated through animal experiments and finite element analysis. A custom-designed dynamic testing apparatus was used to conduct in vitro transverse compression experiments on six sciatic nerve of rats. The Optical
Coherence Tomography(OCT) was utilized to six record the cross-section images of nerve during the testing. Two-dimensional finite element models was built based on the OCT images of nerves. For simplification linear elastic models and a hyperelastic model were employed to describe the stress-strain relationships of the endoneurium, the perineurium and the epineurium respectively. A generalized Maxwell model was employed to describe the stress relaxation response of nerve tissues.
The inverse finite element analysis was used to estimate the material parameters of the three layers of nerve. The result showed that the stiffness of the tissues in decreasing order of the perineurium, endoneurium, epineurium.
Prony series with two term is good enough for the viscoelasticity of the nerve tissues. The integration of OCT and nonlinear finite element modeling can yield the viscoelasticity of peripheral nerve.
第一章 緒論 1
1.4光學同調斷層掃描(Optical Coherence Tomography) 5
第二章 周邊神經材料性質量測 13
第三章 周邊神經之材料數學模型 17
第四章 周邊神經有限元素模型 26
第五章 結果 35
第六章 討論 60
第七章 結論與未來工作 64
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