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系統識別號 U0026-1808201107120500
論文名稱(中文) 探討小光斑與能量密度之二極體雷射系統 應用於除毛的可行性
論文名稱(英文) Investigate Effects of Small Spot Size & Fluence on Hair Removal Using Diode Laser System
校院名稱 成功大學
系所名稱(中) 醫學工程研究所碩博士班
系所名稱(英) Institute of Biomedical Engineering
學年度 99
學期 2
出版年 100
研究生(中文) 江昱緯
研究生(英文) Yu-Wei Chiang
學號 p86984081
學位類別 碩士
語文別 中文
論文頁數 106頁
口試委員 口試委員-王國照
口試委員-蔡明世
口試委員-簡基憲
指導教授-鍾高基
指導教授-曾盛豪
中文關鍵字 除毛  小光斑  熱傷害  二極體雷射  蘭嶼豬 
英文關鍵字 Hair Removal  Small Spot  Heat Injury  Diode Laser  Lanyu Pig 
學科別分類
中文摘要 近年來科技的進步也帶動了醫學美容發展,而除毛雷射更是目前雷射
應用中最常被應用的項目。但市面上的除毛雷射系統,多數以高能量較大
光斑(直徑6~18 mm)進行除毛治療,雖然可縮短除毛療程所需的時間,但
對於毛囊週邊組織的熱傷害具有較高的發生率。使得復原的時間拉長,治
療時也較具疼痛感。本研究的目的為探討直徑1mm小光斑與能量密度(20、
30、40 J/cm2 ) 之二極體雷射系統應用於除毛的可行性。
本研究特定目標:(1)蒙地卡羅模擬光子於組織內部的能量分佈;(2) 小
光斑二極體雷射除毛系統雛型設計;(3)應用動物皮膚組織實驗驗證系統於
除毛的可行性。先運用蒙地卡羅法模擬不同雷射光斑大小在組織間的能量
分佈,考量小光斑雷射除毛的臨床需求與功能設計,並進行小光斑二極體
雷射除毛系統雛型系統設計及校正,最後以蘭嶼豬為動物模型,將耳翼、
頸部腹面部、前肢內側、前肢外側、腹部、後肢鼠蹊外側等部位建立資料
庫,並找出與人相近的部位,以直徑1 mm 小光斑與20、30、40 J/cm2 能
量密度於蘭嶼豬皮膚3cm × 3cm 標記範圍內,針對單一毛孔進行雷射,以
切片染色觀察毛囊形態學的影響,評估小光斑雷射應用於除毛的可行性。
結果顯示:(1) 不同光斑的大小進入表皮層的能量衰減均相同,光斑面積
大小並不影響能量的穿透率,在表皮層下2.25mm 處時穿透率皆約為入射
能量的0.87%;(2) 完成小光斑二極體雷射除毛系統雛型,可達到1.5×1.5cm
毛孔辨識偵測範圍,達到1mm 小光斑飛點掃描之功能;(3) 部位選用實驗
發現蘭嶼豬耳翼皮膚部位的毛囊、汗腺、皮脂腺較具完整性,表皮與真皮
層比例約1:12 與人類最相近,適合進行雷射除毛實驗;(4) 小光斑二極體
雷射除毛動物實驗發現於能量密度30J/cm2 小光斑雷射照射的耳翼皮膚,
切片下可見,表皮層結構、細胞型態完整,毛根處黑色素細胞有部分燒灼
壞死,毛髮皮質破壞,毛囊內、外根鞘可見部分融解,顯見當雷射能量高
於30J/cm2 可達到毛囊破壞之效果驗證小光斑雷射系統於除毛的可行性。
本研究未來可改進及持續研究的項目:(1)持續針對1.5、2mm 光斑直
徑參數進行動物實驗並找出合適雷射除毛參數,並建立皮膚膚色及部位資
料庫,提高影像辨識度;(2)可針對毛囊破壞程度判讀加入科學量化評分。
英文摘要 In recent years, the improvment of science and technology promote
Medicine cosmetology, and laser hair removal is often much more used.In
order to achieve the efficacy of Laser hair removal, laser system usually adopt
a large spot (Diameter 6~18 mm) for treatment. Although the treatment time
could be reduced, big spot will cause unnecessary tissue thermal injury near
hair follicle. The purpose of this research is to investigate small spot size on
hair removal (Diameter 1、mm) and Fluence (20、30、40 J/cm2). This research
utilizes animal testing (Lanyu pig) to probe the feasibility of hair removal by
small spot size and laser diode system.
The specific purposes of this research is : (A) Using Monte Carlo photons
to simulate energy distribution within the tissue. (B) To design the prototype of
small spot size laser diode system. (C) Design the animal test on Lanyu pig.
First we use Monte Carlo to simulate different spot size laser energy
distribution between tissues. Then we design and calibrate the small-spot diode
laser hair removal system prototype system according to clinical needs.Finally,
using the Lanyu pig as animal model, a database was created to identify parts
that are close to human’s. The parts include: the leading edge of the ears, the
side of right neck, the interior of forelimb, forelimb lateral, abdomen and groin
of limbs outside. Laser with 1 mm diameter small spot and 20,30,40 J/cm2
energy density is used to illuminate single pores within a 3cm × 3cm marked
area on the skin. After treatment, we biopsy skin tissues Within the marked area,
and stain the hair follicle to observe it’s morphology, And estimate the
feasibility of hair removal using small spot laser system.
The results showed that: (1) The different spot size of the energy
attenuation into the epidermis are the same. The spot size does not affect the
energy penetration, and the incident energy under 2.25mm of the epidermis
penetration are about 0.87%; (2) Completing the small spot diode laser hair
removal system prototype can reach the detection of pores identify in the range
of 1.5 × 1.5cm, and achieve the function of scanning the small spot in the size
of 1mm ; (3) The experiments of selecting sites on Lanyu pig’s surface of
III
itsear skin has found in the hair follicles, sweat glands, and sebaceous glands
are more integral. The ratio of epidermis and dermis is about 1:12 is the most
similar to humans, and suitable for laser hair removal experiment; (4)
Small spot diode laser hair removal in animal experiments irradiated ear skin
by biopsy .The results show that when conditions are within 1 mm spot size,
fluence 30 J/cm2, we can find out the structure of the cuticular layer and cell
form is unbroken, some root of melanocytes with necrosis, the damage of crinal
cortex, and part melt of the hair follicles and outer root sheath. Therefore, it
proves that there is the feasibility of a new treatment of laser hair removal
when the laser energy is higher than 30 J/cm2.
In this study, future research can improve and sustain the project:(1)
continue searching for appropriate animal hair removal laser parameters hair
removal parameters using 1.5,2 mm diameter spot sizes and establish database
for skin surface color and location to improve the image recognizing system;(2)
scientifically quantitative the damage of hair follicle.
論文目次 中文摘要..................................................................................................Ⅰ
Abstract...................................................................................................Ⅱ
誌謝..........................................................................................................Ⅲ
目錄..........................................................................................................Ⅳ
表目錄......................................................................................................Ⅵ
圖目錄......................................................................................................Ⅶ
第一章 緒論....................................................................................................1
1.1 雷射與醫學美容簡介..............................................................................1
1.1.1 雷射於醫學美容的應用..........................................................3
1.1.2 光與生物組織間的交互作用原理.............................................4
1.1.3 雷射的原理特性與參數變量.................................................12
1.2 雷射除毛的生理機制........................................................................18
1.2.1 皮膚與毛髮的功能性解剖及生理機轉...................................18
1.2.2 雷射除毛的機制.....................................................................24
1.2.3 雷射除毛臨床上的應用與文獻回顧.....................................25
1.3 蒙地卡羅模擬光進入組織間的交互作用........................................28
1.3.1 蒙地卡羅法概述....................................................................28
1.3.2 蒙地卡羅模擬光進入多層組織間的光子追跡......................29
1.3.3 光斑大小及能量在組織間能量衰減之文獻回顧...................35
1.4 研究動機與目的....................................................................................37
第二章 材料與方法.....................................................................................39
2.1 小光斑二極體雷射除毛系統設計........................................................40
2.1.1 蒙地卡羅模擬光斑大小於組織間光子能量分佈...................40
2.1.2 小光斑除毛臨床需求與功能性設計....................................43
2.1.3 小光斑二極體雷射除毛系統雛型設計...................................44
2.1.4 小光斑二極體雷射除毛系統雛型校正..................................63
VI
2.2 小光斑二極體雷射除毛動物實驗..................................................74
2.2.1 動物模型選用................................................................75
2.2.2 儀器設備.....................................................................77
2.2.3 實驗設計與實驗流程.....................................................80
2.2.4 資料分析........................................................................87
第三章 結果與討論.....................................................................................88
3.1 蒙地卡羅模擬光斑大小於組織間光子能量分佈............................88
3.2 小光斑二極體雷射除毛系統雛型....................................................90
3.3 小光斑二極體雷射除毛動物實驗結果............................................100
第四章 結論與未來展望..........................................................................109
參考文獻........................................................................................................111
附錄.....................................................................................................................115
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