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系統識別號 U0026-1707201915294100
論文名稱(中文) 探討漫反射光譜量測系統之系統響應對於混濁介質光學係數計算誤差的影響
論文名稱(英文) Investigation of the influence of instrument response of diffuse reflectance spectroscopy system on the recovery errors of turbid medium optical properties
校院名稱 成功大學
系所名稱(中) 光電科學與工程學系
系所名稱(英) Department of Photonics
學年度 107
學期 2
出版年 108
研究生(中文) 吳慶能
研究生(英文) Ching-Neng Wu
電子信箱 p00506432@gmail.com
學號 L76051150
學位類別 碩士
語文別 中文
論文頁數 48頁
口試委員 指導教授-曾盛豪
口試委員-黃勝廣
口試委員-詹明哲
中文關鍵字 漫反射光譜系統  逆疊加運算系統  光學係數  系統響應  蒙地卡羅法  人工類神經網路 
英文關鍵字 Diffuse reflectance spectroscopy  Inverse adding doubling  optical properties  System response 
學科別分類
中文摘要 漫反射光譜法(Diffuse Reflectance Spectroscopy,DRS)搭配光子傳播模型計算混濁介質的光學係數,廣泛地應用於器官癌病變的篩檢、膚質的檢測、以及量測各種生理參數資訊,提供臨床上的病理特徵判定,此方法具備非侵入式、方便攜帶、設備簡單可微型化等優勢,甚至已開發為市售產品,例如: 飛利浦公司的Bilichek膽紅素檢測儀、Masimo公司的血氧機。
本團隊以漫反射光譜法中的穩態光系統為主,其架構以穩定光源配合複數組SDs距離的光訊號即可計算光學係數,為了獲取待測物的光譜資訊,必須利用校正演算法扣除系統響應,將儀器對光訊號所造成影響去除,才可獲得準確的光學係數,用以分析出正確的皮膚色團濃度,因此扣除系統響應這個環節至關重要,然而,目前的校正演算法在假體驗證上存有缺陷,在不同光學參數組合下的假體校正,其計算的準確定性仍有疑慮,在人體量測甚至計算到吸收負值的現象,因此,檢視系統硬體端與軟體端,歸類出三個變因,針對此三個變因以系統響應比值的觀點分析,進而發現探頭、模型以及假體的光學參數是影響系統響應的主因,為求改善目前計算光學係數的不準確性,從發現的變因當中,以蒙地卡羅模擬搭配類神經網路建構模型的方式,嘗試解決現有的模型問題,透過蒙地卡羅模擬建構兩個不同的模型,量測假體與人體,計算光學係數討論其差異與合理性。
英文摘要 In this study, the steady-state optical system in diffuse reflectance spectroscopy is used. The optical coefficient can be calculated by stabilizing the light source with the multiple SDS distance. In order to obtain the spectral information of the object to be tested, it must be deducted by the calibration algorithm. The system response by removing the influence of the instrument on the optical signal to obtain an accurate optical coefficient to analyze the correct skin chromophore concentration. Therefore, it is important to deduct the system response. However, the current calibration algorithm There are still defects in the phantom verification. The phantom verification under the combination of different optical parameters still has doubts about the uncertainity of the calculation. In the human subject experiment, even the phenomenon of negative absorption is calculated, and the influence is classified after the inspection system. The three factors of system response are analyzed based on the viewpoint of system response ratio for these three variables, and then the optical parameters of the probe, model and phantom are the reasons that affect the system response, in order to improve the inaccuracy of the current calculated optical coefficient. From the founding causes, try to solve the existing model problems and construct two different models through Monte Carlo simulation. Measurement phantom and human, discuss optical coefficient calculated differences and reasonable.
論文目次 摘要II
致謝VI
表目錄IX
圖目錄X
第一章 緒論1
1.1研究背景1
1.2研究動機與目的2
第二章 理論背景4
2.1漫反射光譜學(Diffuse Reflectance Spectroscopy)4
2.2蒙地卡羅法(Monte Carlo Method)5
2.3人工類神經網路(Artificial Neural Network)9
第三章 材料與方法12
3.1固態假體製作與假體校正12
3.1.1固態假體製作12
3.1.2假體校正13
3.2積分球光譜系統14
3.3空間解析漫反射光譜系統(Spatial resolution-DRS)17
第四章 結果與討論19
4.1積分球量測矽膠假體19
4.2空間解析DRS量測-不同假體組合校正20
4.3空間解析DRS量測-系統響應變因探討25
4.3.1 DRS系統於不同光譜儀-假體系統響應比值分析25
4.3.2不同探頭材質與架構-假體系統響應比值分析27
4.3.3蒙地卡羅模擬所建構之ANN模型-假體系統響應比值分析29
4.4假體量測-模型比較34
4.4.1單波長-已知光學特性之假體校正34
4.4.2多波長-已知光學特性之假體校正35
4.5人體量測-模型比較38
4.5.1假體校正人體光學參數負值問題38
4.5.2不同假體校正人體反算光學參數40
第五章 結論與未來工作43
5.1結論43
5.2未來工作44
第六章 參考文獻45
參考文獻 [1] M. Pilz, S. Honold, and A. Kienle, "Determination of the optical properties of turbid media by measurements of the spatially resolved reflectance considering the point-spread function of the camera system," Journal of Biomedical Optics, vol. 13, no. 5, p. 054047, 2008.
[2] T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, "Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy," Review of Scientific Instruments, vol. 71, no. 6, pp. 2500-2513, 2000.
[3] A. Kienle and T. Glanzmann, "In vivodetermination of the optical properties of muscle with time-resolved reflectance using a layered model," Physics in Medicine and Biology, vol. 44, no. 11, pp. 2689-2702, 1999/10/06 1999.
[4] T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, "Diffuse Optics for Tissue Monitoring and Tomography," (in eng), Rep Prog Phys, vol. 73, no. 7, p. 076701, 2010.
[5] S.-H. Tseng, P. Bargo, A. Durkin, and N. Kollias, "Chromophore concentrations, absorption and scattering properties of human skin in-vivo," Optics express, vol. 17, no. 17, pp. 14599-14617, 2009.
[6] A. E. Cerussi, N. S. Shah, D. Hsiang, A. Durkin, J. A. Butler, and B. J. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," Journal of biomedical optics, vol. 11, no. 4, p. 044005, 2006.
[7] E. K. Adams, N. Breen, and P. J. Joski, "Impact of the National Breast and Cervical Cancer Early Detection Program on mammography and pap test utilization among white, Hispanic, and African American women: 1996–2000," Cancer, vol. 109, no. S2, pp. 348-358, 2007.
[8] O. Kujan, A. M. Glenny, R. Oliver, N. Thakker, and P. Sloan, "Screening programmes for the early detection and prevention of oral cancer," Cochrane Database of Systematic Reviews, no. 3, 2006.
[9] D. J. Faber, M. C. G. Aalders, E. G. Mik, B. A. Hooper, M. J. C. van Gemert, and T. G. van Leeuwen, "Oxygen Saturation-Dependent Absorption and Scattering of Blood," Physical Review Letters, vol. 93, no. 2, p. 028102, 07/08/ 2004.
[10] S. Watanabe, S. Yamamoto, M. Yamauchi, N. Tsumura, K. Ogawa-Ochiai, and T. Akiba, "Measuring hemoglobin amount and oxygen saturation of skin with advancing age," in Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV, 2012, vol. 8229: International Society for Optics and Photonics, p. 822905.
[11] C. Zhu, S. Chen, C. H.-K. Chui, B.-K. Tan, and Q. Liu, "Early detection and differentiation of venous and arterial occlusion in skin flaps using visible diffuse reflectance spectroscopy and autofluorescence spectroscopy," Biomedical Optics Express, vol. 7, no. 2, pp. 570-580, 2016/02/01 2016.
[12] M. A. Pleitez, T. Lieblein, A. Bauer, O. Hertzberg, H. von Lilienfeld-Toal, and W. Mäntele, "In vivo noninvasive monitoring of glucose concentration in human epidermis by mid-infrared pulsed photoacoustic spectroscopy," Analytical chemistry, vol. 85, no. 2, pp. 1013-1020, 2012.
[13] J. Liu, B. P.-Y. Yan, W.-X. Dai, X.-R. Ding, Y.-T. Zhang, and N. Zhao, "Multi-wavelength photoplethysmography method for skin arterial pulse extraction," (in eng), Biomedical optics express, vol. 7, no. 10, pp. 4313-4326, 2016.
[14] B. Yu, H. Fu, T. Bydlon, J. E. Bender, and N. Ramanujam, "Diffuse reflectance spectroscopy with a self-calibrating fiber optic probe," Optics letters, vol. 33, no. 16, pp. 1783-1785, 2008.
[15] S. P. Morgan and K. Y. Yong, "Amplitude-phase cross-talk cancellation in frequency domain instrumentation," in Optical Tomography and Spectroscopy of Tissue IV, 2001, vol. 4250: International Society for Optics and Photonics, pp. 269-276.
[16] S. Morgan and K. Yong, "Elimination of amplitude-phase crosstalk in frequency domain near-infrared spectroscopy," Review of Scientific Instruments, vol. 72, no. 4, pp. 1984-1987, 2001.
[17] A. Kim, M. Roy, F. Dadani, and B. C. Wilson, "A fiberoptic reflectance probe with multiple source-collector separations to increase the dynamic range of derived tissue optical absorption and scattering coefficients," Optics express, vol. 18, no. 6, pp. 5580-5594, 2010.
[18] D. Cappon, T. J. Farrell, Q. Fang, and J. E. Hayward, "Fiber-optic probe design and optical property recovery algorithm for optical biopsy of brain tissue," Journal of biomedical optics, vol. 18, no. 10, p. 107004, 2013.
[19] K. Vishwanath et al., "Portable, Fiber-Based, Diffuse Reflection Spectroscopy (DRS) Systems for Estimating Tissue Optical Properties," (in eng), Applied spectroscopy, vol. 62, no. 2, pp. 206-215, 2011.
[20] Y. S. Fawzi, A.-B. M. Youssef, M. H. El-Batanony, and Y. M. Kadah, "Determination of the optical properties of a two-layer tissue model by detecting photons migrating at progressively increasing depths," Applied Optics, vol. 42, no. 31, pp. 6398-6411, 2003/11/01 2003.
[21] S. Banerjee and S. K. Sharma, "Use of Monte Carlo simulations for propagation of light in biomedical tissues," Applied optics, vol. 49, no. 22, pp. 4152-4159, 2010.
[22] L. Wang and S. L. Jacques, "Monte Carlo modeling of light transport in multi-layered tissues in standard C," The University of Texas, MD Anderson Cancer Center, Houston, pp. 4-11, 1992.
[23] G. M. Palmer and N. Ramanujam, "Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms," Applied optics, vol. 45, no. 5, pp. 1062-1071, 2006.
[24] G. Zonios and A. Dimou, "Modeling diffuse reflectance from homogeneous semi-infinite turbid media for biological tissue applications: a Monte Carlo study," Biomedical optics express, vol. 2, no. 12, pp. 3284-3294, 2011.
[25] C. Zhu and Q. Liu, "Review of Monte Carlo modeling of light transport in tissues," Journal of biomedical optics, vol. 18, no. 5, p. 050902, 2013.
[26] Y.-W. Chen and S.-H. Tseng, "Efficient construction of robust artificial neural networks for accurate determination of superficial sample optical properties," Biomedical optics express, vol. 6, no. 3, pp. 747-760, 2015.
[27] Y.-W. Chen, C.-C. Chen, P.-J. Huang, and S.-H. Tseng, "Artificial neural networks for retrieving absorption and reduced scattering spectra from frequency-domain diffuse reflectance spectroscopy at short source-detector separation," Biomedical optics express, vol. 7, no. 4, pp. 1496-1510, 2016.
[28] B. W. Pogue and M. S. Patterson, "Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry," Journal of biomedical optics, vol. 11, no. 4, p. 041102, 2006.
[29] A. Villanueva-Luna et al., "Fabrication and characterization of phantoms made of polydimethylsiloxane (PDMS)," in Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III, 2011, vol. 7906: International Society for Optics and Photonics, p. 79060I.
[30] F. Ayers, A. Grant, D. Kuo, D. J. Cuccia, and A. J. Durkin, "Fabrication and characterization of silicone-based tissue phantoms with tunable optical properties in the visible and near infrared domain," in Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue, 2008, vol. 6870: International Society for Optics and Photonics, p. 687007.
[31] P. Di Ninni, F. Martelli, and G. Zaccanti, "The use of India ink in tissue-simulating phantoms," Optics Express, vol. 18, no. 26, pp. 26854-26865, 2010/12/20 2010.
[32] S. Hyttel-Sorensen, S. Kleiser, M. Wolf, and G. Greisen, "Calibration of a prototype NIRS oximeter against two commercial devices on a blood-lipid phantom," Biomedical Optics Express, vol. 4, no. 9, pp. 1662-1672, 2013/09/01 2013.
[33] V. Sorgato et al., "ACA-Pro: calibration protocol for quantitative diffuse reflectance spectroscopy. Validation on contact and noncontact probe-and CCD-based systems," Journal of biomedical optics, vol. 21, no. 6, p. 065003, 2016.
[34] S. A. Prahl, M. J. van Gemert, and A. J. Welch, "Determining the optical properties of turbid media by using the adding–doubling method," Applied optics, vol. 32, no. 4, pp. 559-568, 1993.
[35] S. N. Thennadil and Y.-c. Chen, "Alternative measurement configurations for extracting bulk optical properties using an integrating sphere setup," Applied spectroscopy, vol. 71, no. 2, pp. 224-237, 2017.
[36] R. B. Saager, C. Kondru, K. Au, K. Sry, F. Ayers, and A. J. Durkin, "Multilayer silicone phantoms for the evaluation of quantitative optical techniques in skin imaging," in Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue II, 2010, vol. 7567: International Society for Optics and Photonics, p. 756706.
[37] P. Naglič, F. Pernuš, B. Likar, and M. Bürmen, "Limitations of the commonly used simplified laterally uniform optical fiber probe-tissue interface in Monte Carlo simulations of diffuse reflectance," (in eng), Biomedical optics express, vol. 6, no. 10, pp. 3973-3988, 2015.

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