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系統識別號 U0026-1706201419083600
論文名稱(中文) 二維電磁感應加熱之生物熱傳分析
論文名稱(英文) 2-D Bio-heat transfer analysis with electromagnetic induction heating
校院名稱 成功大學
系所名稱(中) 機械工程學系碩士在職專班
系所名稱(英) Department of Mechanical Engineering (on the job class)
學年度 102
學期 2
出版年 103
研究生(中文) 黃銘德
研究生(英文) Min-Te Huang
學號 N17961049
學位類別 碩士
語文別 中文
論文頁數 79頁
口試委員 口試委員-魏蓬生
口試委員-陳志臣
口試委員-陳寒濤
指導教授-張錦裕
中文關鍵字 電磁感應加熱  生物熱傳  血液灌注率 
英文關鍵字 electromagnetic induction heating  bio-heat transfer  blood perfusion 
學科別分類
中文摘要 本文利用電磁學、熱傳學等相關學理,探討電磁感應針具加熱過程及生物組織內溫度分佈,根據豬的椎間盤及人體肝臟腫瘤幾何尺寸,建立二維軸對稱物理模型進行數值模擬,本研究同時做實驗量測溫度以驗證模擬結果之準確性,另外,研究結果以豬椎間盤之溫度變化及人體肝臟腫瘤之溫度變化來呈現,藉以了解應用電磁感應加熱技術在腫瘤治療過程的有效熱治療範圍。
在實驗部分使用豬的椎間盤進行溫度量測,探討不同針具直徑(0.7mm、0.9mm)、針具與感應線圈不同位置距離(4mm、9mm)及不同電流值(198A、249A及289A)情況下之感應加熱情形。並將溫度場模擬結果與實驗進行分析比對,研究發現發現當輸入電流固定時,針具直徑0.9mm較0.7mm溫度上升約7%左右,而當針具離線圈距離為9mm時的加熱溫度效果較4mm距離愈差,整體的溫度下降約9 %左右。整體而言,針具表面之量測溫度與數值模擬的整體誤差值約在6 %以下。
另外,模擬探討人體肝臟腫瘤在針具不同直徑(1mm、1.5mm及2mm),模擬結果發現當輸入條件相同時,針具直徑dN =2.0mm較dN =1.0mm溫度約可提升57 % 左右。最後,模擬探討腫瘤的血液灌注率變化(ωbt=0、0.004762、0.009524及0.019 m3/s•m3 tissue )時,對針具治療效果的影響,模擬結果發現當腫瘤的血液灌注率ωbt=0(m3/s•m3 tissue )與ωbt=0.019(m3/s•m3 tissue )時,(1)針具直徑dN=1.0mm的最高溫度差約22 %,,針具治療範圍最大為6.5mm。(2)針具直徑dN=1.5 mm的最高溫度差約24 %,針具治療範圍最大為7mm。(3)針具直徑dN=2.0mm的最高溫度差約26 %,針具治療範圍最大為7.2mm。
關鍵詞:電磁感應加熱、生物熱傳、血液灌注率
英文摘要 2-D Bio-heat Transfer Analysis with Electromagnetic Induction Heating
Min-Te, Huang
Jiin-Yuh, Jang
Department Of Mechanical Engineering, National Cheng Kung University
SUMMARY
In the present study, the principle associated with electromagnetic and conduction heat transfer is adopted to investigate electromagnetic induction heating process of a needle and temperature distribution within the biological tissue. The 2-D axis-symmetry physical models according to the geometry of swine intervertebral disc and human hepatic tumors are established for numerical simulation. Experimental measurements were conducted to validate the accuracy of numerical simulation. In addition, the results in terms of temperature variation within the swine intervertebral disc and human hepatic tumors are established to explore the effective therapy area of tumor treatment through induction heating technique. Overall, the analyzed numerical results are compared with the swine intervertebral disc experimental data. The total deviation between the experimental measurement and numerical simulation is less than 6% for the temperature at needle surface. In addition, different diameters of needles (1mm, 1.5mm and 2mm) are conducted for the human’s hepatic tumor. The results showed the temperature for needle diameter of 2.0mm is 57% higher than that of 1.0mm.
Key words: electromagnetic induction heating, bio-heat transfer, blood perfusion
INTRODUCTION
Electromagnetic induction heating has been extensively explored in medical history as a tool for cancer treatment. Electromagnetic induction heating is a simple and straight-forward treatment with fewer side effects. Recently, induction heating approaches including radio frequency ablation , microwave ablation and electromagnetic thermotherapy by using the alternating magnetic field to heat the magnetic material to high temperature. Electromagnetic field ablation has been extensively explored and has proven to be effective for localized thermal ablation. It uses magnetic materials under an alternating magnetic field to generate heat due to the induced eddy currents and the hysteresis energy loss. With this approach, high temperatures can be induced and used for the ablation of tissues or tumor cells. Furthermore, a two-section needle which includes the magnetic section and the non-magnetic section has been designed for the electromagnetic thermal ablation.
MATERIALS AND METHODS
Our high-frequency electromagnetic thermotherapy system consisted of a electromagnetic field generator, a cooling water circulation system, induction coils(diameter=66mm), two-section needle, and a data recorder system which is used to record the needle surface temperature. The 2-D axis-symmetry physical models according to the geometry of swine intervertebral disc and human hepatic tumors are established for numerical simulation. Experimental measurements were conducted to validate the accuracy of numerical simulation.
RESULTS AND DISCUSSION
In the present study, for experimental temperature measurements with regard to the swine intervertebral disc, parameters such as needle diameters (0.7mm、0.9mm), distances between the needles and induction coils(4mm、9mm) and input current values (198A、249A and 289A) are performed to capture the temperature distributions within the disc. Figure 1. displays the effect of needles diameters on the heating curve of intervertebral disc. The result show that the deviation between the experimental measurement and numerical simulation is less than 3% for the temperature at needle surface. Figure 2. displays the effect of distances between the needles and induction coils on the heating curve of intervertebral disc. The result show that the deviation between the experimental measurement and numerical simulation is less than 6% for the temperature at needle surface. Figure 3. displays the effect of input current values on the heating curve of intervertebral disc. The result show that the deviation between the experimental measurement and numerical simulation is less than 5% for the temperature at needle surface. In addition, different diameters of needles (1mm, 1.5mm and 2mm) are conducted for the human’s hepatic tumor. Furthermore, the effect of tumor’s blood perfusion on the thermal therapy is investigated (ωbt=0, 0.004762, 0.009524 and 0.019 m3/s•m3 tissue ). Figure 4. displays the temperature distributions of hepatic tumor for different needles diameters. The results showed the temperature for needle diameter of 2.0mm is 57% higher than that of 1.0mm. Figure 5. displays the temperature distributions of hepatic tumor for different blood perfusion rate. Under the simulation condition of dN=1.5mm, the result shows when the tumor’s blood perfusion rate are changed: (1)CASE A, the range of needle therapeutic is up to 7mm. (2)CASE B, the range of needle therapeutic is up to 5mm. (3)CASE C, the range of needle therapeutic is up to 3.7mm. (4)CASE D, the range of needle therapeutic is up to 2.6mm.
CONCLUSION
The analyzed numerical results has been compared with the experimental data. The result show that when the input current value is fixed, the temperature for the needle with diameter of 0.9mm is about 7% higher than that of 0.7mm. As far as the effective therapy area is concerned, the needle being away 9mm from coil has poorer effectiveness than that of 4mm due to the fact that the whole temperature drops about 9%. Overall, the total deviation between the experimental measurement and numerical simulation is less than 6% for the temperature at needle surface. In addition, different diameters of needles (1mm, 1.5mm and 2mm) are conducted for the human’s hepatic tumor. The results showed the temperature for needle diameter of 2.0mm is 57% higher than that of 1.0mm. Furthermore, the effect of tumor’s blood perfusion on the thermal therapy is investigated (ωbt=0, 0.004762, 0.009524 and 0.019 m3/s•m3 tissue ) . The result shows when the tumor’s blood perfusion rate are ωbt =0 (m3/s•m3 tissue) and ωbt =0.019(m3/s•m3 tissue): (1) Needle diameter dN=1.0mm, the maximum temperature difference is about 22%, and the range of needle therapeutic is up to 6.5mm. (2) Needle diameter dN=1.5mm, the maximum temperature difference is about 24%, and the range of needle therapeutic is up to 7mm. (3) Needle diameter dN= 2.0mm, the maximum temperature difference is about 26%, the range of needle therapeutic is up to 7.2mm.



Figure 1. Different needles diameters for numerical and experimental temperature
comparison chart (intervertebral disc)

Figure 2. Different distances between the needles and induction coils for numerical
and experimental temperature comparison chart (intervertebral disc)

Figure 3. Different input current for numerical and experimental temperature
comparison chart (intervertebral disc)


Figure 4. Different needles diameters for numerical temperature comparison chart
(hepatic tumor)

Figure 5. Different blood perfusion rate for numerical temperature comparison chart
(hepatic tumor),dN=1.5mm
論文目次 摘 要 I
Summary II
誌 謝 VI
目 錄 VII
表 目 錄 VIII
圖 目 錄 IX
符號說明 XI
第一章 緒 論 1
第二章 理論分析 19
第三章 數值方法 35
第四章 實驗設備與方法 44
第五章 結果與討論 54
第六章 結論 74
參考文獻 76
自 述 79
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