系統識別號 U0026-1607202016290700
論文名稱(中文) 動物神經回饋訓練平台及大腦記憶穩固與強化
論文名稱(英文) An Animal Neurofeedback Training Platform for Memory Consolidation and Enhancement
校院名稱 成功大學
系所名稱(中) 資訊工程學系
系所名稱(英) Institute of Computer Science and Information Engineering
學年度 108
學期 2
出版年 109
研究生(中文) 施宇軒
研究生(英文) Yu-Hsuan Shih
學號 P78031028
學位類別 博士
語文別 英文
論文頁數 48頁
口試委員 指導教授-梁勝富
中文關鍵字 神經回饋訓練  alpha節律  工作記憶  動物實驗 
英文關鍵字 neurofeedback  alpha rhythm  working memory  animal study 
中文摘要 神經回饋訓練是一針對腦部功能之訓練,透過中樞神經系統去調控大腦活性的自我訓練。大多利用影像或聲音,給予正回饋或負回饋,腦機介面觀察腦波特定頻帶的變化,透過操作型制約讓使用者能察覺大腦特定的活性,進而從中學習控制自我的腦波。神經回饋訓練近幾年來已經成為受關注的非侵入性大腦症狀改善方法,已應用於焦慮、憂鬱、失眠等之改善。此外,對健康人的 Alpha波神經回饋訓練,已證實可增進工作記憶的表現。神經回饋的大腦反應區域與反應機制,目前仍然非常有限,透過動物模型,可進一步確認其大腦機制。然而,如何將大腦反應呈現給動物、訓練動物強化特定腦波頻帶、驗證動物接受神經回饋訓練後不同腦功能表現有否提升,都是必須面對的基本挑戰。本研究將開發動物神經回饋訓練系統之平台,驗證老鼠是否可藉由此平台強化Alpha腦波表現 並觀察動物Alpha波提升是否對不同記憶功能,如短期記憶與長期記憶,也有所提升。本研究已經開發出一套可以讓動物進行神經回饋訓練的平台並且經過實驗驗證,此系統將十隻實驗鼠進行實驗,分別五隻進行神經回饋訓練、五隻為控制組採取隨機餵食,由結果得知老鼠的腦波經由本系統訓練Alpha確實可以提升,並且在行為測試實驗組相較於控制組更快速進入狀況。
英文摘要 Neurofeedback training (NFT) of the alpha rhythm has been wildly used to enhance working memory but its trainability and effects on working memory is yet to be fully unveiled. Alpha rhythm of the frontoparietal region are associated with either the intelligence or memory of healthy subjects and are also related to pathological states. In this study, alpha NFT effects on memory performances were explored. A total of 10 rats were randomly assigned into the NFT group receiving food rewards when 8–13 Hz alpha activity was detected and the sham group receiving a random food reward. There were 3 NFT sessions per week conducted for 4 weeks. Working memory was assessed by T-maze pre-test and post-test for 9 consecutive days. The sham group had no significant change in alpha amplitude. In contrast, the NFT group showed a significant increase in the alpha amplitude. The accuracy of working memories was significantly improved in the NFT group. This study provides supporting evidence for the alpha trainability in rats. The results suggest the enhancement of working memory through alpha NFT.
論文目次 摘 要 I
Acknowledgement III
List of Tables VI
List of Figures VII
Chapter 1 Introduction 1
1.1 Memory 1
1.2 Neurofeedback 7
1.3 Alpha Rhythm 9
1.4 Alpha Rhythm on Memory 11
1.5 Motivation and Objective 14
1.6 Thesis Overview 14
Chapter 2 An Animal Neurofeedback Training Platform for Memory Consolidation and Enhancement 15
2.1 Animal Preparation 15
2.2 Neurofeedback Platform 18
2.2.1 3D Printing Model Design Pellet Dispenser 20
2.2.2 Arduino programming 24
2.2.3 Graphic User Interface 25
Chapter 3 Neurofeedback Training and Memory Test 27
3.1.1 T-maze Memory Test 28
3.1.2 Neurofeedback Value 31
Chapter 4 Results 32
Chapter 5 Discussion 36
Chapter 6 Conclusion 38
Reference 39
Appendix A 47
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