進階搜尋


 
系統識別號 U0026-1607202016290700
論文名稱(中文) 動物神經回饋訓練平台及大腦記憶穩固與強化
論文名稱(英文) An Animal Neurofeedback Training Platform for Memory Consolidation and Enhancement
校院名稱 成功大學
系所名稱(中) 資訊工程學系
系所名稱(英) Institute of Computer Science and Information Engineering
學年度 108
學期 2
出版年 109
研究生(中文) 施宇軒
研究生(英文) Yu-Hsuan Shih
學號 P78031028
學位類別 博士
語文別 英文
論文頁數 48頁
口試委員 指導教授-梁勝富
召集委員-蕭富仁
口試委員-張大緯
口試委員-王淵弘
口試委員-郭至恩
中文關鍵字 神經回饋訓練  alpha節律  工作記憶  動物實驗 
英文關鍵字 neurofeedback  alpha rhythm  working memory  animal study 
學科別分類
中文摘要 神經回饋訓練是一針對腦部功能之訓練,透過中樞神經系統去調控大腦活性的自我訓練。大多利用影像或聲音,給予正回饋或負回饋,腦機介面觀察腦波特定頻帶的變化,透過操作型制約讓使用者能察覺大腦特定的活性,進而從中學習控制自我的腦波。神經回饋訓練近幾年來已經成為受關注的非侵入性大腦症狀改善方法,已應用於焦慮、憂鬱、失眠等之改善。此外,對健康人的 Alpha波神經回饋訓練,已證實可增進工作記憶的表現。神經回饋的大腦反應區域與反應機制,目前仍然非常有限,透過動物模型,可進一步確認其大腦機制。然而,如何將大腦反應呈現給動物、訓練動物強化特定腦波頻帶、驗證動物接受神經回饋訓練後不同腦功能表現有否提升,都是必須面對的基本挑戰。本研究將開發動物神經回饋訓練系統之平台,驗證老鼠是否可藉由此平台強化Alpha腦波表現 並觀察動物Alpha波提升是否對不同記憶功能,如短期記憶與長期記憶,也有所提升。本研究已經開發出一套可以讓動物進行神經回饋訓練的平台並且經過實驗驗證,此系統將十隻實驗鼠進行實驗,分別五隻進行神經回饋訓練、五隻為控制組採取隨機餵食,由結果得知老鼠的腦波經由本系統訓練Alpha確實可以提升,並且在行為測試實驗組相較於控制組更快速進入狀況。
英文摘要 Neurofeedback training (NFT) of the alpha rhythm has been wildly used to enhance working memory but its trainability and effects on working memory is yet to be fully unveiled. Alpha rhythm of the frontoparietal region are associated with either the intelligence or memory of healthy subjects and are also related to pathological states. In this study, alpha NFT effects on memory performances were explored. A total of 10 rats were randomly assigned into the NFT group receiving food rewards when 8–13 Hz alpha activity was detected and the sham group receiving a random food reward. There were 3 NFT sessions per week conducted for 4 weeks. Working memory was assessed by T-maze pre-test and post-test for 9 consecutive days. The sham group had no significant change in alpha amplitude. In contrast, the NFT group showed a significant increase in the alpha amplitude. The accuracy of working memories was significantly improved in the NFT group. This study provides supporting evidence for the alpha trainability in rats. The results suggest the enhancement of working memory through alpha NFT.
論文目次 摘 要 I
ABSTRACT II
Acknowledgement III
List of Tables VI
List of Figures VII
Chapter 1 Introduction 1
1.1 Memory 1
1.2 Neurofeedback 7
1.3 Alpha Rhythm 9
1.4 Alpha Rhythm on Memory 11
1.5 Motivation and Objective 14
1.6 Thesis Overview 14
Chapter 2 An Animal Neurofeedback Training Platform for Memory Consolidation and Enhancement 15
2.1 Animal Preparation 15
2.2 Neurofeedback Platform 18
2.2.1 3D Printing Model Design Pellet Dispenser 20
2.2.2 Arduino programming 24
2.2.3 Graphic User Interface 25
Chapter 3 Neurofeedback Training and Memory Test 27
3.1.1 T-maze Memory Test 28
3.1.2 Neurofeedback Value 31
Chapter 4 Results 32
Chapter 5 Discussion 36
Chapter 6 Conclusion 38
Reference 39
Appendix A 47
參考文獻 Angelakis, E., Stathopoulou, S., Frymiare, J. L., Green, D. L., Lubar, J. F., & Kounios, J. (2007). EEG neurofeedback: a brief overview and an example of peak alpha frequency training for cognitive enhancement in the elderly. The clinical neuropsychologist, 21(1), 110-129.
Atkinson, R. C. & Shiffrin, R. M. (1968). Human memory: A proposed system and its control processes.
Baddeley, A. D. (2000). The episodic buffer: a new component of working memory?. Trends in cognitive sciences, 4(11), 417-423.
Baddeley, A. D. (2002). Is working memory still working?. European psychologist, 7(2), 85.
Baddeley, A. D. (2007). Working memory, thought, and action (Vol. 45). OuP Oxford.
Baddeley, A. D., & Hitch, G. (1974). Working memory. In Psychology of learning and motivation (Vol. 8, pp. 47-89). Academic press.
Bauer, R. H. (1976). Short-term memory: EEG alpha correlates and the effect of increased alpha. Behavioral biology, 17(4), 425-433.
Boynton, T. (2001). Applied research using alpha/theta training for enhancing creativity and well-being. Journal of Neurotherapy, 5(1-2), 5-18.
Cervena, K., Espa, F., Perogamvros, L., Perrig, S., Merica, H., & Ibanez, V. (2014). Spectral analysis of the sleep onset period in primary insomnia. Clinical Neurophysiology, 125(5):979–987.
Cho, M. K., Jang, H. S., Jeong, S. H., Jang, I. S., Choi, B. J., & Lee, M. G. T. (2008). Alpha neurofeedback improves the maintaining ability of alpha activity. Neuroreport, 19(3), 315-317.
Cortoos, A., Valck, E. D., Arns, M., Breteler, M. H., & Cluydts, R. (2010). An exploratory study on the effects of tele-neurofeedback and tele-biofeedback on objective and subjective sleep in patients with primary insomnia. Applied psychophysiology and biofeedback, 35(2):125–134.
Daly, J. J. & Wolpaw, J. R. (2008). Brain-computer interfaces in neurological rehabilitation. The Lancet Neurology, 7(11):1032–1043.
Egner, T., & Gruzelier, J. H. (2003). Ecological validity of neurofeedback: modulation of slow wave EEG enhances musical performance. Neuroreport, 14(9), 1221-1224.
Enriquez-Geppert, S., Smit, D., Pimenta, M. G., & Arns, M. (2019). Neurofeedback as a treatment intervention in ADHD: Current evidence and practice. Current psychiatry reports, 21(6), 46.
Ericsson, K. A., & Kintsch, W. (1995). Long-term working memory. Psychological review, 102(2), 211.
Escolano, C., Aguilar, M., & Minguez, J. (2011, August). EEG-based upper alpha neurofeedback training improves working memory performance. In 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 2327-2330). IEEE.
Escolano, C., Navarro-Gil, M., Garcia-Campayo, J., & Minguez, J. (2014). The effects of a single session of upper alpha neurofeedback for cognitive enhancement: a sham-controlled study. Applied psychophysiology and biofeedback, 39(3-4), 227-236.
Eysenck, M. (2012). Attention and arousal: Cognition and performance. Springer Science & Business Media.
Foerde, K., Knowlton, B. J., & Poldrack, R. A. (2006). Modulation of competing memory systems by distraction. proceedings of the National Academy of Sciences, 103(31), 11778-11783.
Gazzaniga, M. S. (1991). Interview with endel tulving. Journal of cognitive neuroscience, 3(1):89–94.
Graf, P., & Schacter, D. L. (1985). Implicit and explicit memory for new associations in normal and amnesic subjects. Journal of Experimental Psychology: Learning, memory, and cognition, 11(3), 501.
Gruzelier, J. H. (2014). EEG-neurofeedback for optimising performance. I: a review of cognitive and affective outcome in healthy participants. Neuroscience & Biobehavioral Reviews, 44:124–141.
Hammond, D. C. (2005). Neurofeedback treatment of depression and anxiety. Journal of Adult Development, 12(2-3):131–137.
Hanslmayr, S., Sauseng, P., Doppelmayr, M., Schabus, M., and Klimesch, W. (2005). Increasing individual upper alpha power by neurofeedback improves cognitive performance in human subjects. Applied psychophysiology and biofeedback, 30(1):1–10.
Haynes, J.-D. & Rees, G. (2006). Decoding mental states from brain activity in humans. Nature Reviews Neuroscience, 7(7):523–534.
Healy, S. D. & Jozet-Alves, C. (2010). Spatial memory. Encyclopedia of Animal Behavior, pages 304–307.
Heller, W., Nitschke, J. B., Etienne, M. A., & Miller, G. A. (1997). Patterns of regional brain activity differentiate types of anxiety. Journal of abnormal psychology, 106(3):376.
Holtmann, M., Steiner, S., Hohmann, S., Poustka, L., Banaschewski, T., & Bölte, S. (2011). Neurofeedback in autism spectrum disorders. Developmental Medicine & Child Neurology, 53(11), 986-993.
Hsueh, J. J., Chen, T. S., Chen, J. J., & Shaw, F. Z. (2016). Neurofeedback training of EEG alpha rhythm enhances episodic and working memory. Human brain mapping, 37(7), 2662-2675.
Jaimchariyatam, N., Rodriguez, C. L., & Budur, K. (2011). Prevalence and correlates of alpha-delta sleep in major depressive disorders. Innovations in clinical neuroscience, 8(7):35.
Juhel, J. (2011). The effects of neurofeedback training on memory performance in elderly subjects. Psychology, 2(08), 846.
Kimmig, A. C. S., Dresler, T., Hudak, J., Haeussinger, F. B., Wildgruber, D., Fallgatter, A. J., ... & Kreifelts, B. (2019). Feasibility of NIRS-based neurofeedback training in social anxiety disorder: behavioral and neural correlates. Journal of Neural Transmission, 126(9), 1175-1185.
Klimesch, W. (1999). EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. Brain research reviews, 29(2-3):169–195.
Klimesch, W., Doppelmayr, M., & Hanslmayr, S. (2006). Upper alpha ERD and absolute power: their meaning for memory performance. Progress in brain research, 159:151– 165.
Klimesch, W., Sauseng, P., & Hanslmayr, S. (2007). EEG alpha oscillations: the inhibition-timing hypothesis. Brain research reviews, 53(1):63–88.
Kotsos, T. (2015). Brain Waves and the Deeper States of Consciousness. https://www.mind-your-reality.com/brain_waves.html.
Lubar, J. F., Swartwood, M. O., Swartwood, J. N., & O'Donnell, P. H. (1995). Evaluation of the effectiveness of EEG neurofeedback training for ADHD in a clinical setting as measured by changes in TOVA scores, behavioral ratings, and WISC-R performance. Biofeedback and Self-regulation, 20(1), 83-99.
Mano, M., Lécuyer, A., Bannier, E., Perronnet, L., Noorzadeh, S., & Barillot, C. (2017). How to build a hybrid neurofeedback platform combining EEG and fMRI. Frontiers in neuroscience, 11:140.
Melton, A. W. (1963). Implications of short-term memory for a general theory of memory. Journal of verbal Learning and verbal Behavior, 2(1):1–21.
Miller, G. A. (1956). The magical number seven, plus or minus two: Some limits on our capacity for processing information. Psychological review, 63(2):81.
Monastra, V. J., Lynn, S., Linden, M., Lubar, J. F., Gruzelier, J., & La Vaque, T. J. (2006). Electroencephalographic biofeedback in the treatment of attention-deficit/hyperactivity disorder. Journal of neurotherapy, 9(4), 5-34.
Nakamura-Palacios, E. M., & Levin, E. S. (2011). Working memory and prefrontal cortex and their relation with the brain reward system and drug addiction. Working memory: capacity, developments and improvement techniques (Levin ES, ed), New York: Nova Science Publishers, 109-139.
Nan, W., Rodrigues, J. P., Ma, J., Qu, X., Wan, F., Mak, P.-I., Mak, P. U., Vai, M. I., & Rosa, A. (2012). Individual alpha neurofeedback training effect on short term memory. International journal of psychophysiology, 86(1):83–87.
Oh, J., Hofer, R., & Fitch, W. T. (2017). An open source automatic feeder for animal experiments. HardwareX, 1:13– 21.
Ortega-de San Luis, C., & Ryan, T. J. (2018). United states of amnesia: rescuing memory loss from diverse conditions.
Paxinos, G., & Watson, C. (1998). The rat brain in stereotaxic coordinates Academic Press San Diego. California, USA.
Paxinos, G., Watson, C., Pennisi, M., & Topple, A. (1985). Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight. Journal of neuroscience methods, 13(2):139–143.
Pérez-Elvira, R., Carrobles, J. A., Bote, D. J. L., & Oltra-Cucarella, J. (2019). Efficacy of Live Z-Score neurofeedback training for chronic insomnia: A single-case study. NeuroRegulation, 6(2), 93-93.
Reddy, J. K., & Sneha, C. S. (2019). EEG Neurofeedback Brain Training for Epilepsy to Reduce Seizures. International Journal of Child Development and Mental Health, 7(1), 28-33.
Sauseng, P., Klimesch, W., Schabus, M., & Doppelmayr, M. (2005). Fronto-parietal EEG coherence in theta and upper alpha reflect central executive functions of working memory. International journal of Psychophysiology, 57(2):97–103.
Sherwood, L. (2015). Human physiology: from cells to systems. Cengage learning.
Sitaram, R., Lee, S., Ruiz, S., Rana, M., Veit, R., & Birbaumer, N. (2011). Real-time support vector classification and feedback of multiple emotional brain states. Neuroimage, 56(2):753–765.
Sitaram, R., Ros, T., Stoeckel, L., Haller, S., Scharnowski, F., Lewis-Peacock, J., Weiskopf, N., Blefari, M. L., Rana, M., & Oblak, E. (2017). Closed-loop brain training: the science of neurofeedback. Nature Reviews Neuroscience, 18(2):86.
Spiegel, D. R., Smith, J., Wade, R. R., Cherukuru, N., Ursani, A., Dobruskina, Y., ... & Dreyer, N. (2017). Transient global amnesia: current perspectives. Neuropsychiatric disease and treatment, 13, 2691.
Sterman, M. B., Howe, R. C., & Macdonald, L. R. (1970). Facilitation of spindle-burst sleep by conditioning of electroencephalographic activity while awake. Science, 167(3921), 1146-1148.
Sterman, M. B., & Egner, T. (2006). Foundation and practice of neurofeedback for the treatment of epilepsy. Applied psychophysiology and biofeedback, 31(1), 21.
Szpunar, K. K. (2010). Episodic future thought: An emerging concept. Perspectives on Psychological Science, 5(2), 142-162.
Talpos, J. C., Aerts, N., Fellini, L., & Steckler, T. (2014). A touch-screen based paired-associates learning (PAL) task for the rat may provide a translatable pharmacological model of human cognitive impairment. Pharmacology Biochemistry and Behavior, 122:97–106.
Tatum, W. O. (2014). Ellen r. grass lecture: Extraordinary eeg. The Neurodiagnostic Journal, 54(1):3–21.
Tulving, E., & Schacter, D. L. (1990). Priming and human memory systems. Science, 247(4940), 301-306.
van Boxtel, G. J., & Gruzelier, J. H. (2014). Neurofeedback: introduction to the special issue. Biological Psychology, 95(1), 1-3.
Van Doren, J., Arns, M., Heinrich, H., Vollebregt, M. A., Strehl, U., & Loo, S. K. (2019). Sustained effects of neurofeedback in ADHD: a systematic review and meta-analysis. European child & adolescent psychiatry, 28(3), 293-305.
Vernon, D., Egner, T., Cooper, N., Compton, T., Neilands, C., Sheri, A., & Gruzelier, J. (2003). The effect of training distinct neurofeedback protocols on aspects of cognitive performance. International journal of psychophysiology, 47(1):75–85.
Vernon, D. J. (2005). Can neurofeedback training enhance performance? An evaluation of the evidence with implications for future research. Applied psychophysiology and biofeedback, 30(4):347.
Wang, J.-R. & Hsieh, S. (2013). Neurofeedback training improves attention and working memory performance. Clinical Neurophysiology, 124(12):2406–2420.
Wang, S. Y., Lin, I. M., Fan, S. Y., Tsai, Y. C., Yen, C. F., Yeh, Y. C., ... & Wang, P. W. (2019). The effects of alpha asymmetry and high-beta down-training neurofeedback for patients with the major depressive disorder and anxiety symptoms. Journal of affective disorders, 257, 287-296.
Wei, T. Y., Chang, D. W., Liu, Y. D., Liu, C. W., Young, C. P., Liang, S. F., & Shaw, F. Z. (2017). Portable wireless neurofeedback system of EEG alpha rhythm enhances memory. Biomedical engineering online, 16(1), 1-18.
Wenk, G. L. (1998). Assessment of spatial memory using the T maze. Current protocols in neuroscience, 4(1):8–5.
Zhao, Z., Yao, S., Li, K., Sindermann, C., Zhou, F., Zhao, W., ... & Becker, B. (2019). Real-time functional connectivity-informed neurofeedback of amygdala-frontal pathways reduces anxiety. Psychotherapy and psychosomatics, 88(1), 5-15.
Zoefel, B., Huster, R. J., & Herrmann, C. S. (2011). Neurofeedback training of the upper alpha frequency band in EEG improves cognitive performance. Neuroimage, 54(2):1427–1431.
論文全文使用權限
  • 同意授權校內瀏覽/列印電子全文服務,於2020-07-27起公開。
  • 同意授權校外瀏覽/列印電子全文服務,於2020-07-27起公開。


  • 如您有疑問,請聯絡圖書館
    聯絡電話:(06)2757575#65773
    聯絡E-mail:etds@email.ncku.edu.tw