系統識別號 U0026-1302201416051800
論文名稱(中文) 電子設備的使用與孩童弭患氣喘及過敏性疾病和哮喘之相關性研究
論文名稱(英文) Association Between Usage of Electrical Equipment and Childhood Allergies and Asthma
校院名稱 成功大學
系所名稱(中) 環境醫學研究所
系所名稱(英) Institute of Environmental and Occupational Health
學年度 102
學期 1
出版年 103
研究生(中文) 貝琳答
研究生(英文) Belinda N. Makadia
電子信箱 belindamakadia2011@gmail.com
學號 S76017021
學位類別 碩士
語文別 英文
論文頁數 61頁
口試委員 指導教授-蘇慧貞
中文關鍵字 室內空氣  氣喘  過敏性鼻炎  濕疹  電子設備  揮發性有機化合物 
英文關鍵字 Indoor air  asthma  rhinitis  eczema  electrical equipment  VOC 
中文摘要 世界各地孩童氣喘及過敏性疾病之發病率出現令人擔憂的增長趨勢,探究可能因素,顯示環境暴露是考量遺傳因素後的一項重要影響因子。隨著科技的蓬勃發展,室內空間所使用的電器種類日漸繁多,然而由其衍生的汙染物是否貢獻於孩童過敏氣喘之發生仍是不清楚。因此本研究擬嘗試釐清2-6歲學齡前孩童罹患氣喘或其他過敏性疾病與其居家電器設備使用之關係。
本研究在單變量分析中發現使用真空吸塵器、空氣蒸汽增濕機、空氣清淨機、除濕機、負離子空氣清淨機和個人電腦會和至少兩種以上的過敏性疾病呈現顯著的正相關係(p-value < 0.005)。
在邏輯斯回歸模式校正性別、年齡、家族過敏性疾病史、抽菸等相關變數後,發現電子設備的使用與過敏性疾病的發生呈現統計上的正相關。空氣清淨機的使用與發生氣喘、過敏性鼻炎及濕疹其勝算比依序為1.46、1.347、1.192,所對應的p-value依序為小於 0.001、小於0.001、0.005。在空氣蒸汽增濕機的使用與發生過敏性鼻炎及濕疹其勝算比的部分依序為1.241、1.146、1.194,所對應的p-value依序為0.007、小於0.001、0.003。在使用負離子空氣清淨機與發生過敏性鼻炎及濕疹其勝算比的部分依序為1.314、1.335、1.310,所對應的p-value依序為0.008、小於0.001、小於0.001。另外在使用電視與發生濕疹的勝算比部分為1.230,所對應的p-value為0.002。
英文摘要 There is an alarming global increase in asthma and allergic disease incidences especially in children, an indication that the cause may be due to changes in environmental exposure rather than genetics. With modernization and improved technology, the indoor environment has had an influx of electrical equipment and appliances. However, there is little known about the effect on children’s health caused by electrical equipment and appliances. Therefore, this study aims to investigate the association between electrical equipment usage and childhood allergy and asthma.
We take advantage of data collected by structured questionnaire survey conducted in 2005 with the aim of identifying the relationship between indoor environmental quality in the home and preschool children’s health. A total of 14862 questionnaires were collected in preschool children aged 2-6 years in the greater Tainan metropolitan area of southern Taiwan. Chi-square tests were applied to assess the association between home characteristics and presence of asthma, allergic rhinitis, and eczema among participants. Besides, logistic regression models have been used to evaluate the risk of home electrical appliances with adjustments for gender, age, family history of allergic disease and smoking behavior.
The baseline descriptive statistics showed that there were 6482, boys (51.5%) and 6101 girls (48.5%) with a mean age of 5.0 years old (standard deviation= 0.99). The prevalence for doctor diagnosed asthma, doctor diagnosed allergic rhinitis and eczema in the last 6 months was 9.3%, 19.3% and 17.6% respectively.
Univariate analysis indicated that vacuum cleaner, humidifier, air cleaner, air humidifier, ionizer, television and Personal computer have positive associations with increased prevalence of at least two of the three diseases (p<0.005 for all variables). In adjusted logistic regression models, all electronics increase the odds of having all diseases outcome. Air cleaner is significant for asthma (OR: 1.46; p< 0.001), rhinitis OR: 1.347; p<0.001), eczema (OR: 1.192; p= 0.005), air humidifier is significant for asthma (OR: 1.241; p=0.007), rhinitis (OR: 1.416; p<0.001), eczema (OR: 1.194; p=0.003), Ionizer is significant for asthma (OR: 1.314; p=0.008), rhinitis (OR: 1.335; p<0.001), eczema (OR: 1.310; p<0.001).TV is significant for eczema (OR: 1.230; p=0.002).
Air cleaner, air humidifier, and ionizer showed statistical significant results. Interestingly, televisions and Personal computers showed positive associations with children’s allergic diseases. TV that is older than 5 years of age increases the risk of rhinitis significantly (6-10yrs, OR: 1.286; p=0.024, <10yrs, OR: 1.255; p=0.047). A child spending mean time of 1.18hours on a weekday with PC had an increased risk of asthma (OR: 1.021; p=0.006). The location and age of TV may also influence the occurrence of asthma and eczema. Sensitivity analysis made no significant change to previous results. Interaction analysis shows that TV affects more boys than girls in rhinitis occurrence (OR: 1.347; p=0.011).
In conclusion, electronic devices at home may be risk factors for allergic diseases, specifically air humidifier, air cleaner, ionizer and TV.
中文摘要 II
1.1 Research Background 1
1.2 Prevalence of Allergic Diseases 1
1.3 Burden and Impact of Diseases 2
2.1 Asthma. 4
2.1.1 Mechanism of asthma 4
2.1.2 Asthma Triggers: 6
2.2 Atopic Dermatitis/ Eczema 6
2.2.1 Description 6
2.2.2 Mechanism for Atopic Dermatitis 7
2.2.3 Triggers for AD 8
2.3 Allergic Rhinitis 8
2.3.1 Description 8
2.4 Allergies (Asthma, Rhinitis, Eczema) and Indoor Air 8
2.5 Problem Statement 9
2.5.1 Electronic Equipment at Home 9
2.5.2 Why Electronics?? 10
2.6 Objective 14
3.1 Subject Selection 15
3.1.1 Who is at risk? 15
3.2 Study Design 16
3.2.1 Questionnaires 17
3.3 Statistical Analysis 19
5.2 Study subjects’ baseline characteristics effects on outcome. 27
5.2.1 Chi-Square tests for Electronic Effects 29
5.3 Television and Personal Computers 30
5.4 Sensitivity Analysis 31
5.5 Interactions 31
參考文獻 Amelink M, Berger M, de Nijs S, Weersink E, Sterk P, Bel E. 2010. Male Gender And Absence Of Atopy Are Associated With Persistent Airflow Limitation In Adult Onset Asthma. Am J Respir Crit Care Med 181.
Annesi-Maesano I, Hulin M, Lavaud F, Raherison C, Kopferschmitt C, de Blay F, et al. 2012. Poor air quality in classrooms related to asthma and rhinitis in primary schoolchildren of the French 6 Cities Study. Thorax 67: 682-8.
Arrighi HM, Cook CK, Redding GJ. 1996. The prevalence and impact of allergic rhinitis among teenagers. Journal of Allergy and Clinical Immunology 97: 990-.
Bai JA, Zhao J, Shen KL, Xiang L, Chen AH, Huang S, et al. 2010. Current Trends of the Prevalence of Childhood Asthma in Three Chinese Cities : A Multicenter Epidemiological Survey. Biomedical and Environmental Sciences 23: 453-7.
Barro R, Regueiro J, Llompart M, Garcia-Jares C. 2009. Analysis of industrial contaminants in indoor air: part 1. Volatile organic compounds, carbonyl compounds, polycyclic aromatic hydrocarbons and polychlorinated biphenyls. J Chromatogr A 1216: 540-66.
Beasley R, Ellwood P, Asher I. 2003. International patterns of the prevalence of pediatric asthma - The ISAAC program. Pediatr Clin North Am 50: 539-+.
Becker K, Goen T, Seiwert M, Conrad A, Pick-Fuss H, Muller J, et al. 2009. GerES IV: Phthalate metabolites and bisphenol A in urine of German children. Int J Hyg Environ Health 212: 685-92.
Bel EH. 2013. Obesity and Asthma Control Do Gender, Age, and Ethnicity Really Matter? Am J Respir Crit Care Med 187: 667-8.
Billionnet C, Gay E, Kirchner S, Leynaert B, Annesi-Maesano I. 2011. Quantitative assessments of indoor air pollution and respiratory health in a population-based sample of French dwellings. Environ Res 111: 425-34.
Bjorksten B, Clayton T, Ellwood P, Stewart A, Strachan D, Grp IPIS. 2008. Worldwide time trends for symptoms of rhinitis and conjunctivitis: Phase III of the International Study of Asthma and Allergies in Childhood. Pediatric Allergy and Immunology 19: 110-24.
Boguniewicz M, Leung DY. 2006. 10. Atopic dermatitis. J Allergy Clin Immunol 117: S475-80.
Boguniewicz M, Schmid-Grendelmeier P, Leung DY. 2006. Atopic dermatitis. J Allergy Clin Immunol 118: 40-3.
Bonner JC. 2010. Nanoparticles as a potential cause of pleural and interstitial lung disease. Proc Am Thorac Soc 7: 138-41.
Bornehag CG, Lundgren B, Weschler CJ, Sigsgaard T, Hagerhed-Engman L, Sundell J. 2005. Phthalates in indoor dust and their association with building characteristics. Environ Health Perspect 113: 1399-404.
Bornehag CG, Nanberg E. 2010. Phthalate exposure and asthma in children. International Journal of Andrology 33: 333-45.
Bornehag CG, Sundell J, Sigsgaard T. 2004. Dampness in buildings and health (DBH): Report from an ongoing epidemiological investigation on the association between indoor environmental factors and health effects among children in Sweden. Indoor Air 14: 59-66.
Borrell LN, Nguyen EA, Roth LA, Oh SS, Tcheurekdjian H, Sen S, et al. 2013. Childhood Obesity and Asthma Control in the GALA II and SAGE II Studies. Am J Respir Crit Care Med 187: 697-702.
Bousquet J, van Cauwenberge P, Khaltaev N, Ait-Khaled N, Annesi-Maesano I, Bachert C, et al. 2001. Allergic rhinitis and its impact on asthma. Journal of Allergy and Clinical Immunology 108: S147-S334.
Braman SS. 2006. The global burden of asthma. Chest 130: 4S-12S.
Brockow I, Zutavern A, Franke K, Schaaf B, von Berg A, Kramer U, et al. 2008. Influences of lifestyle-related factors on the immune system and the development of allergies in childhood (LISA). Design and results to date of a prospective birth cohort study. Monatsschrift Kinderheilkunde 156: 249-55.
2000. Asthma and Rhinitis 1. 2 ed. Hoboken, New Jersey (United States) Wiley-Blackwell.
Buttke DE, Wolkin A, Stapleton HM, Miranda ML. 2013. Associations between serum levels of polybrominated diphenyl ether (PBDE) flame retardants and environmental and behavioral factors in pregnant women. Journal of Exposure Science and Environmental Epidemiology 23: 176-82.
Charpin-Kadouch C, Mouche JM, Queralt J, Ercoli J, Hugues B, Garon M, et al. 2008. [Housing and health counselling services in the management of allergic respiratory disease]. Rev Mal Respir 25: 821-7.
Chiang LC, Chen YH, Hsueh KC, Huang JL. 2007. Prevalence and severity of symptoms of asthma, allergic rhinitis, and eczema in 10- to 15-year-old schoolchildren in central Taiwan. Asian Pac J Allergy Immunol 25: 1-5.
Chivu R, Iamandescu I, Chivu L, Ion D, Armean P. 2008. Epidemiologic aspects of child asthma in Romania: urban residence and male gender are strong risk factors for asthma. Allergy 63: 305-.
Choi H, Schmidbauer N, Sundell J, Hasselgren M, Spengler J, Bornehag CG. 2010. Common Household Chemicals and the Allergy Risks in Pre-School Age Children. PLoS One 5.
Civelek E, Cakir B, Orhan F, Yuksel H, Boz AB, Uner A, et al. 2011. Risk Factors for Current Wheezing and Its Phenotypes Among Elementary School Children. Pediatr Pulmonol 46: 166-74.
Cookson W. 2004. The immunogenetics of asthma and eczema: A new focus on the epithelium. Nature Reviews Immunology 4: 978-88.
de Vocht F. 2010. "Dirty electricity": what, where, and should we care? J Expo Sci Environ Epidemiol 20: 399-405.
Dervisevic I, Minic D, Kamberovic Z, Cosovic V, Ristic M. 2013. Characterization of PCBs from computers and mobile phones, and the proposal of newly developed materials for substitution of gold, lead and arsenic. Environmental Science and Pollution Research 20: 4278-92.
Dong GH, Qian ZM, Wang J, Trevathan E, Ma WJ, Chen WQ, et al. 2013. Residential characteristics and household risk factors and respiratory diseases in Chinese women: The Seven Northeast Cities (SNEC) Study. Science of the Total Environment 463: 389-94.
Eller E, Roll S, Chen CM, Herbarth O, Wichmann HE, von Berg A, et al. 2008. Meta-analysis of determinants for pet ownership in 12 European birth cohorts on asthma and allergies: a GA2LEN initiative. Allergy 63: 1491-8.
2007. The Asthma Educator's Handbook. 1 ed. New York City, United States: McGraw-Hill Publishers.
Garcia E, Aristizabal G, Vasquez C, Rodriguez-Martinez CE, Sarmiento OL, Satizabal CL. 2008. Prevalence of and factors associated with current asthma symptoms in school children aged 6-7 and 13-14 yr old in Bogota, Colombia. Pediatric Allergy and Immunology 19: 307-14.
Gerez IFA, Lee BW, van Bever HP, Shek LP. 2010. Allergies in Asia: differences in prevalence and management compared with Western populations. Expert Review of Clinical Immunology 6: 279-89.
Graif Y, German L, Ifrah A, Livne I, Shohat T. 2013. Dose-Response Association between Smoking and Atopic Eczema: Results from a Large Cross-Sectional Study in Adolescents. Dermatology 226: 195-9.
Greiner AN, Hellings PW, Rotiroti G, Scadding GK. 2011. Allergic rhinitis. Lancet 378: 2112-22.
Hassmanova V, Vaneckova J, Bousova K. 2000. [Occupational diseases caused by chromium and its compounds]. Acta Medica (Hradec Kralove) Suppl 43: 33-6.
Hawrylowicz CM, O'Garra A. 2005. Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma. Nat Rev Immunol 5: 271-83.
Herbarth O, Franck U, Geiss O, Kohajda T, Matysik S, Tirendi S, et al. 2008. Exposure Pattern Assessment-the NOMIRACLE and the MILAGRO Project-importance of Indoor VOC for Allergic Symptoms/Eczema. Epidemiology 19: S176-S.
Hulin M, Annesi-Maesano I, Caillaud D. 2011. Indoor air quality at school and allergy and asthma among schoolchildren. Differences between rural and urban areas. Revue Francaise D Allergologie 51: 419-24.
Hulin M, Caillaud D, Annesi-Maesano I. 2010. Indoor air pollution and childhood asthma: variations between urban and rural areas. Indoor Air 20: 502-14.
Huss-Marp J, Eberlein-Konig B, Breuer K, Mair S, Ansel A, Darsow U, et al. 2006. Influence of short-term exposure to airborne Der p 1 and volatile organic compounds on skin barrier function and dermal blood flow in patients with atopic eczema and healthy individuals. Clinical and Experimental Allergy 36: 338-45.
Jensen JM, Folster-Holst R, Baranowsky A, Schunck M, Winoto-Morbach S, Neumann C, et al. 2004. Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis. Journal of Investigative Dermatology 122: 1423-31.
Kabesch M. 2004. [Genetics and allergies: consequences for the practitioner?]. MMW Fortschr Med 146: 45, 7-8.
2010. ABC of asthma. 6 ed. Hoboken, New Jersey (United States): Wiley-Blackwell.
Kanoh M, Kaneita Y, Hara M, Harada S, Gon Y, Kanamaru H, et al. 2012. Longitudinal study of parental smoking habits and development of asthma in early childhood. Preventive Medicine 54: 94-6.
Kemp AS. 2003. Cost of illness of atopic dermatitis in children - A societal perspective. Pharmacoeconomics 21: 105-13.
Kim BJ, Kwon JW, Kwon HJ, Leem JH, Kim HC, Yu J, et al. 2011a. The Exposure to Ozone Is Associated With Asthma, Allergic Rhinitis, and Allergic Sensitization in Schoolchildren. Epidemiology 22: S198-S9.
Kim BJ, Kwon JW, Seo JH, Kim HB, Lee SY, Park KS, et al. 2011b. Association of ozone exposure with asthma, allergic rhinitis, and allergic sensitization. Annals of Allergy Asthma & Immunology 107: 214-9.
Kolarik B, Bornehag CG, Naydenov K, Sundell J, Stavova P, Nielsen OF. 2008a. The concentrations of phthalates in settled dust in Bulgarian homes in relation to building characteristic and cleaning habits in the family. Atmos Environ 42: 8553-9.
Kolarik B, Naydenov K, Larsson M, Bornehag CG, Sundell J. 2008b. The association between phthalates in dust and allergic diseases among Bulgarian children. Environ Health Perspect 116: 98-103.
Koshy G, Delpisheh A, Brabin BJ. 2010. Trends in prevalence of childhood and parental asthma in Merseyside, 1991-2006. Journal of Public Health 32: 488-95.
Larsson M, Hagerhed-Engman L, Kolarik B, James P, Lundin F, Janson S, et al. 2010. PVC - as flooring material - and its association with incident asthma in a Swedish child cohort study. Indoor Air 20: 494-501.
Larsson M, Hagerhed-Engman L, Sigsgaard T, Janson S, Sundell J, Bornehag CG. 2008. Incidence rates of asthma, rhinitis and eczema symptoms and influential factors in young children in Sweden. Acta Paediatrica 97: 1210-5.
Le Cann P, Bonvallot N, Glorennec P, Deguen S, Goeury C, Le Bot B. 2011. Indoor environment and children's health: recent developments in chemical, biological, physical and social aspects. Int J Hyg Environ Health 215: 1-18.
Lee YL, Hwang BF, Lin YC, Guo YL. 2007. Time trend of asthma prevalence among school children in Taiwan: ISAAC phase I and III surveys. Pediatric Allergy and Immunology 18: 188-95.
Li XB, Xu ST. 2012. Analysis on Thermal Reliability of Key Electronic Components on PCB. Information-an International Interdisciplinary Journal 15: 5719-24.
Liao MF, Huang JL, Chiang LC, Wang FY, Chen CY. 2005. Prevalence of asthma, rhinitis, and eczema from ISAAC survey of schoolchildren in Central Taiwan. J Asthma 42: 833-7.
Manion AB. 2013. Asthma and Obesity: The Dose Effect. Nursing Clinics of North America 48: 151-+.
Surveillance for asthma - United States 1960-1995 [update; cited 2013 Available from: http://www.cdc.gov/mmwr/preview/mmwrhtml/00052262.htm.
Masoli M, Fabian D, Holt S, Beasley R, Program G. 2004. The global burden of asthma: executive summary of the GINA Dissemination Committee Report. Allergy 59: 469-78.
Mathew AC, Steephen S, David R, Ramalingam S, Krishnamurthy S. 2011. Parental atopy and exposure to pets on asthma: a hospital-based case-control study. Int J Prev Med 2: 151-7.
McAleer MA, Flohr C, Irvine AD. 2012. Management of difficult and severe eczema in childhood. British Medical Journal 345.
McGwin G, Lienert J, Kennedy JI. 2011. Formaldehyde exposure and asthma in children: a systematic review. Cien Saude Colet 16: 3845-52.
Meltzer EO. 2001. Quality of life in adults and children with allergic rhinitis. Journal of Allergy and Clinical Immunology 108: S45-S53.
Meltzer EO, Blaiss MS, Derebery MJ, Mahr TA, Gordon BR, Sheth KK, et al. 2009. Burden of allergic rhinitis: Results from the Pediatric Allergies in America survey. Journal of Allergy and Clinical Immunology 124: S43-S70.
Mendell MJ. 2007. Indoor residential chemical emissions as risk factors for-respiratory and allergic effects in children: a review. Indoor Air 17: 259-77.
Messer A. 2010. Mini-review: polybrominated diphenyl ether (PBDE) flame retardants as potential autism risk factors. Physiol Behav 100: 245-9.
Meyer HW, Wurtz H, Suadicani P, Valbjorn O, Sigsgaard T, Gyntelberg F. 2005. Molds in floor dust and building-related symptoms among adolescent school children: a problem for boys only? Indoor Air 15 Suppl 10: 17-24.
Montefort S, Ellul P, Montefort M, Caruana S, Grech V, Muscat HA. 2012. The effect of cigarette smoking on allergic conditions in Maltese children (ISAAC). Pediatric Allergy and Immunology 23: 472-8.
Moonie SA, Sterling DA, Figgs L, Castro M. 2006. Asthma Status and Severity Affects Missed School Days. Journal of School Health 76: 18-24.
Nomura I, Tanaka K, Tomita H, Katsunuma T, Ohya Y, Ikeda N, et al. 1999. Evaluation of the staphylococcal exotoxins and their specific IgE in childhood atopic dermatitis. Journal of Allergy and Clinical Immunology 104: 441-6.
Okabe Y, Adachi Y, Itazawa T, Yoshida K, Ohya Y, Odajima H, et al. 2012. Association between obesity and asthma in Japanese preschool children. Pediatr Allergy Immunol 23: 550-5.
Osman M, Hansell AL, Simpson CR, Hollowell J, Helms PJ. 2007. Gender-specific presentations for asthma, allergic rhinitis and eczema in primary care. Prim Care Respir J 16: 28-35.
Palvo F, Toledo EC, Menin AMCR, Jorge PPO, Godoy MF, Sole D. 2008. Risk factors of childhood asthma in Sao Jose do Rio Preto, Sao Paulo, Brazil. J Trop Pediatr 54: 253-7.
Pappas GP, Herbert RJ, Henderson W, Koenig J, Stover B, Barnhart S. 2000. The respiratory effects of volatile organic compounds. Int J Occup Environ Health 6: 1-8.
2004. Asthma. 21 ed. United States: Elsevier.
2007. 100 Questions and Answers About Your Child's Asthma. 1 ed. Ontario, Canada: Jonhn and Bartlett.
Quirce S, Barranco P. 2010. Cleaning Agents and Asthma. Journal of Investigational Allergology and Clinical Immunology 20: 542-50.
Renkonen J, Mattila P, Parviainen V, Joenvaara S, Toppila-Salmi S, Renkonen R. 2010. A network analysis of the single nucleotide polymorphisms in acute allergic diseases. Allergy 65: 40-7.
Ring J. 1993. The Skin and the Environment. Hautarzt 44: 625-35.
Rullo VE, Rizzo MC, Arruda LK, Sole D, Naspitz CK. 2002. Daycare centers and schools as sources of exposure to mites, cockroach, and endotoxin in the city of Sao Paulo, Brazil. J Allergy Clin Immunol 110: 582-8.
S B. 1998. Volatile Organic Compounds (VOCs) from electrical equipment in the home & office.
Sehra S, Tuana FMB, Holbreich M, Mousdicas N, Kaplan MH, Travers JB. 2008. Clinical correlations of recent developments in the pathogenesis of atopic dermatitis. Anais Brasileiros De Dermatologia 83: 57-73.
Selgrade MK, Lemanske RF, Gilmour MI, Neas LM, Ward MDW, Henneberger PK, et al. 2006. Induction of asthma and the environment: What we know and need to know. Environ Health Perspect 114: 615-9.
Seltzer JM. 1994. Biological Contaminants. Journal of Allergy and Clinical Immunology 94: 318-26.
Sharma R, Gaur SN, Singh VP, Singh AB. 2012. Association between indoor fungi in Delhi homes and sensitization in children with respiratory allergy. Medical Mycology 50: 281-90.
Shyu CS, Lin HK, Lin CH, Fu LS. 2012. Prevalence of attention-deficit/hyperactivity disorder in patients with pediatric allergic disorders: a nationwide, population-based study. J Microbiol Immunol Infect 45: 237-42.
Steyn NP, Labadarios D, Nel JH. 2011. Factors which influence the consumption of street foods and fast foods in South Africa-a national survey. Nutrition Journal 10.
Strachan DP. 2000. The role of environmental factors in asthma. British Medical Bulletin 56: 865-82.
Su JC, Kemp AS, Varigos GA, Nolan TM. 1997. Atopic eczema: Its impact on the family and financial cost. Arch Dis Child 76: 159-62.
Sublett JL. 2011. Effectiveness of Air Filters and Air Cleaners in Allergic Respiratory Diseases: A Review of the Recent Literature. Curr Allergy Asthma Rep 11: 395-402.
Sultan ZM, Nilsson GJ, Magee RJ. 2011. Removal of ultrafine particles in indoor air: Performance of various portable air cleaner technologies. Hvac&R Research 17: 513-25.
Tanaka-Kagawa T, Jinno H, Furukawa Y, Nishimura T. 2010. [Volatile organic compounds (VOCs) emitted from furniture and electrical appliances]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku: 71-7.
Tanaka K, Miyake Y, Arakawa M. 2012. Smoking and prevalence of allergic disorders in Japanese pregnant women: baseline data from the Kyushu Okinawa Maternal and Child Health Study. Environmental Health 11.
Tavernier GO, Fletcher GD, Francis HC, Oldham LA, Fletcher AM, Blacklock G, et al. 2005. Endotoxin exposure in asthmatic children and matched healthy controls: results of IPEADAM study. Indoor Air 15 Suppl 10: 25-32.
Tsai HJ, Tsai AC, Nriagu J, Ghosh D, Gong M, Sandretto A. 2007. Associations of BMI, TV-watching time, and physical activity on respiratory symptoms and asthma in 5th grade schoolchildren in taipei, taiwan. Journal of Asthma 44: 397-401.
Tsuang HA, Su HJJ, Kao FF, Shih HC. 2003. Effects of changing risk factors on increasing asthma prevalence in southern Taiwan. Paediatr Perinat Epidemiol 17: 3-9.
EPA. Child-Specific Exposure Factors Handbook (Final Report) 2008 [update; cited 2013 Available from: http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=199243.
van Beijsterveldt CEM, Boomsma DI. 2007. Genetics of parentally reported asthma, eczema and rhinitis in 5-yr-old twins. European Respiratory Journal 29: 516-21.
Vicedo-Cabrera AM, Garcia-Marcos L, Llopis-Gonzalez A, Lopez-Silvarrey-Varela A, Miner-Canflanca I, Batlles-Garrido J, et al. 2012. Atopic dermatitis and indoor use of energy sources in cooking and heating appliances. BMC Public Health 12.
Wen S, Yang FX, Gong Y, Zhang XL, Hui Y, Li JG, et al. 2008. Elevated levels of urinary 8-hydroxy-2'-deoxyguanosine in male electrical and electronic equipment dismantling workers exposed to high concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans, polybrominated diphenyl ethers, and polychlorinated biphenyls. Environ Sci Technol 42: 4202-7.
Weschler CJ. 2009. Changes in indoor pollutants since the 1950s. Atmos Environ 43: 153-69.
Williams H, Robertson C, Stewart A, Ait-Khaled N, Anabwani G, Anderson R, et al. 1999. Worldwide variations in the prevalence of symptoms of atopic eczema in the international study of asthma and allergies in childhood. Journal of Allergy and Clinical Immunology 103: 125-38.
Wirehn ABE, Karlsson HM, Carstensen JM. 2007. Estimating disease prevalence using a population-based administrative healthcare database. Scand J Public Health 35: 424-31.
Yan DC, Ou LS, Tsai TL, Wu WF, Huang JL. 2005. Prevalence and severity of symptoms of asthma, rhinitis, and eczema in 13-to 14-year-old children in Taipei, Taiwan. Annals of Allergy Asthma & Immunology 95: 579-85.
Yang HJ, Kim HJ, Yu J, Lee E, Jung YH, Kim HY, et al. 2013. Inhalation toxicity of humidifier disinfectants as a risk factor of children's interstitial lung disease in Korea: a case-control study. PLoS One 8: e64430.
Yeh KW, Chiang LC, Huang JL. 2008. Epidemiology and current status of asthma and associated allergic diseases in Taiwan- ARIA Asia-Pacific Workshop report. Asian Pac J Allergy Immunol 26: 257-64.
Yeh KW, Ou LS, Yao TC, Chen LC, Lee WI, Huang JL. 2011. Prevalence and risk factors for early presentation of asthma among preschool children in Taiwan. Asian Pac J Allergy Immunol 29: 120-6.
Yu KP, Lee GWM, Hsieh CP, Lin CC. 2011. Evaluation of ozone generation and indoor organic compounds removal by air cleaners based on chamber tests. Atmos Environ 45: 35-42.
Zhang X, Diamond ML, Robson M, Harrad S. 2011a. Sources, emissions, and fate of polybrominated diphenyl ethers and polychlorinated biphenyls indoors in Toronto, Canada. Environ Sci Technol 45: 3268-74.
Zhang YP, Mo JH, Li YG, Sundell J, Wargocki P, Zhang JS, et al. 2011b. Can commonly-used fan-driven air cleaning technologies improve indoor air quality? A literature review. Atmos Environ 45: 4329-43.
Zuraimi MS, Tham KW, Chew FT, Ooi PL. 2007. The effect of ventilation strategies of child care centers on indoor air quality and respiratory health of children in Singapore. Indoor Air 17: 317-27.
Zuraimi MS, Tham KW, Chew FT, Ooi PL, Koh D. 2011. Home air-conditioning, traffic exposure, and asthma and allergic symptoms among preschool children. Pediatric Allergy and Immunology 22: e112-e8.
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