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系統識別號 U0026-1102201914451100
論文名稱(中文) 利用兆赫波塑膠線波導之消逝場實現分子感測應用
論文名稱(英文) Terahertz wave sensing applications using the evanescent field of a plastic wire waveguide
校院名稱 成功大學
系所名稱(中) 光電科學與工程學系
系所名稱(英) Department of Photonics
學年度 107
學期 1
出版年 108
研究生(中文) 曾琬玲
研究生(英文) Wan-Ling Tseng
學號 L76044218
學位類別 碩士
語文別 中文
論文頁數 144頁
口試委員 指導教授-呂佳諭
口試委員-李佳榮
口試委員-劉子安
口試委員-游博文
中文關鍵字 兆赫波  次波長波導  分子感測  波導消逝場 
英文關鍵字 terahertz waves  subwavlength waveguide  molecular sensing  waveguide evanescent wave 
學科別分類
中文摘要 此論文成功證實兆赫波塑膠線波導於微量分子感測應用,從實驗觀察中分析塑膠介質核心的幾何形狀,與其可傳頻率範圍之關係,以及樣品基板中之奈米孔洞結構之必要性,此研究進一步使用磷酸鹽緩衝液為標準樣品,成功取得塑膠線消逝波在各種孔洞尺寸基板之感測能力,並且與彩帶波導比較其感測能力;在同樣的兆赫波頻率與微量分子條件下,塑膠線整合樣品基板之感測靈敏度比彩帶波導載負樣品之感測靈敏度高。基於此塑膠線整合樣品基板之最佳光學條件,可以展現各種顆粒狀與液滴狀分子造成樣品基板之不同波導響應,包括穿透率低值(或是損耗峰值)頻譜偏移,0.3 THz之損耗係數變化,以及等效波導折射係數或是損耗係數之頻譜變化等。此論文成功辨識醣類分子,包括葡萄糖、蔗糖、乳糖等,其感測解析能力約4-7 nmol/mm2左右,也成功辨識鹽類分子,包括海鹽與磷酸鹽兩種,其中感測解析能力約在20-60 nmol/mm2,此外,此波導感測技術法也能夠辨識抗體-抗原分子結合前後之差異。根據等效介質概念,此論文也發展塑膠線波導消逝波波之折射係數感測模型,期望可以從所量測的樣品基板之波導折射係數頻譜,進而可以取得待測分子之本質折射係數頻譜,這是目前所有光學感測技術法中最具挑戰而不容易達到之處,此論文已經從純液體沾附樣品基板之感測實驗中,說明此模型中所需要的樣品條件與其可信度,因此,塑膠線波導之消逝波感測技術法,未來將可以配合不同奈米孔洞尺寸的基板,將極微量的分子呈現可辨識的兆赫頻譜訊號,供應生物、化學等分析用途。
英文摘要 The thesis successfully demonstrates a plastic-wire terahertz (THz) waveguide is workable for sensing the minute molecules. The experimental observation first illustrates the relation between dielectric core geometry and the waveguide spectrum. The sample substrate with nano-porous structure is then revealed as the critical element of the waveguide sensing configuration. Based on the sensitivity calibration with the standard sample of DPBS (Dulbecco's Phosphate-Buffered Saline), various porous substrates are discussed for their sensing abilities while being integrated with evanescent waves of a plastic-wire waveguide. The sensitivity of substrate-integrated plastic wire sensor is also compared with the ribbon waveguides with the porous structures in the study. For the same waveguide frequency and minute amounts of sample, the sensitivity of substrate-integrated plastic wire sensor is higher than that of a ribbon waveguide sensor. Based on the optimal geometry of substrate-integrated plastic-wire sensor, molecules in particles and drops can be recognized from different waveguide properties of the sample substrate, including the spectral shift of transmittance dip (or attenuation peak), attenuation coefficient variation at 0.3 THz, and the variation of effective waveguide refractive indices or attenuation coefficients.
論文目次 目錄
考試合格證明………………………………………...……………………....I
摘要……………………..…………………...…………………….………....II
Extended Abstract……………………………………...………..………...III
致謝……………………………………………………………………....….VI
目錄………………………………………………………………..…….....VII
圖目錄………………………………………………………………….……IX
表目錄…………………………………………………………….…......XVIII
第一章 簡介…………………..…………………...………….……………...1
第二章 兆赫波介質波導之傳輸特性……………………..…………….…..3
2-1量測系統與方法……………………..…………………...………………….3
2-2各類型式介質波導……………………..……………………………….....…4
2-3波導傳輸參數定義……………………..…………………........…….………8
2-4量測結果……………………..…………………...…………………...……9
2-5分析與討論……………………..…………………....................………….22
第三章 兆赫波導之光學感測方法………………………...………………24
3-1塑膠線波導感測系統……………………..……………………………...…24
3-2樣品使用與製備方法……………………..………………………...………33
3-3光學感測執行步驟……………………..………………………………...…38
3-4波導系統感測靈敏度……………………..…………………………...……42
第四章 兆赫波塑膠線波導之感測模型……………………..…………….57
4-1波導折射係數感測模型……………………..…………………...……….…57
4-2實現波導折射係數感測模型之可行性評估……………………..……….…..72
第五章 兆赫波塑膠線波導之分子感測應用……………………..….……83
5-1醣類分子感測……………………..………………………………..……...83
5-2鹽類分子感測……………………..………………………………..…...…92
5-3有機高分子感測與討論分析……………………..……………….…………96
5-4生物抗體-抗原分子感測……………………..……………………...……..101
第六章 結論與未來展望……………………..………………………...…108
參考文獻……………………..………………….....………………………111
附錄……………………..………………………………………………….114
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