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系統識別號 U0026-0812200915253464
論文名稱(中文) 運動訓練對第二型糖尿病大鼠於內毒素血症時心肺功能的影響
論文名稱(英文) Effect of exercise pretraining on cardiopulmonary functions in Type II diabetic rats during endotoxemia
校院名稱 成功大學
系所名稱(中) 物理治療研究所
系所名稱(英) Department of Physical Therapy
學年度 97
學期 2
出版年 98
研究生(中文) 高銘鍵
研究生(英文) Ming-chein Kao
電子信箱 t6695108@mail.ncku.edu.tw
學號 t6695108
學位類別 碩士
語文別 中文
論文頁數 128頁
口試委員 口試委員-鄭瑞棠
指導教授-洪菁霞
口試委員-陳郁文
中文關鍵字 胰島素阻抗  腫瘤壞死因子α  運動訓練  心肺功能  內毒素血症  熱休克蛋白72 
英文關鍵字 HSP72  exercise training  cardiopulmonary function  TNF-α  endotoxemia  insulin resistance  type 2 diabetes mellitus  fructose-fed rat 
學科別分類
中文摘要 研究背景及目的:全世界罹患糖尿病的族群中約有90%屬於第二型糖尿病,而第二型糖尿病的病程發展到後來,容易因周圍神經病變造成感覺遲鈍,肢段受傷不自知而引起傷口感染,導致細菌進入血液而產生內毒素血症;嚴重的內毒素血症會造成血液灌流不足的低血壓及心肺功能衰竭,而內毒素引起的全身性發炎反應,會產生腫瘤壞死因子(TNF-α)等發炎前驅物質,進一步引起肺部損傷和多重器官衰竭。運動是第二型糖尿病患的主要治療方式之一,而胰島素阻抗為第二型糖尿病發展之初最主要的症狀之一;透過運動訓練或熱刺激能在大鼠多重器官內,誘發保護性熱休克蛋白72(HSP72),保護受到破壞的蛋白質以維持其正常的功能。
過去的研究已證實,運動訓練可於第一型糖尿病大鼠誘發內毒素血症後有效延長存活時間及增加存活率,且於大鼠許多臟器產生HSP72,因此,我們欲了解是否經運動訓練後的第二型糖尿病大鼠,於肌肉、心臟、肺臟等器官相同會產生大量HSP72,以保護組織、維持器官功能。研究方法:將Wistar大鼠分成第二型糖尿病及正常鼠,第二型糖尿病鼠以60%果糖飼料誘發胰島素阻抗動物模式,兩種大鼠再進行4週、30~60分鐘/週並以20~30公尺/分鐘的速度於自動跑步機運動訓練。最後一次運動訓練後24小時,將大鼠麻醉後注射LPS誘發內毒素血症,監測平均動脈壓、心跳、血壓、心輸出量及心搏量。誘發內毒素血症後四小時,偵測血液氣體變化、血清及肺灌洗液中TNF-α濃度、肺部病理切片、肺灌洗液中白蛋白含量及肺乾濕重比;並取下大鼠心臟、肺臟、肝臟、腎臟、骨骼肌、延腦背側區之孤立束核及下視丘以測其中HSP72的含量。結果:正常鼠及第二型糖尿病鼠誘發內毒素血症後,血液動力學參數顯著下降、血清內TNF-α含量增加、肺乾溼重比增加、動脈氧分壓增加和動脈二氧化碳分壓減少以及病理切片中發現肺泡間隙變厚且白血球浸潤的現象,但肺灌洗液內TNF-α及白蛋白含量則無顯著差異。誘發內毒素血症後,經4週運動訓練後的正常鼠及第二型糖尿病鼠於上述的許多器官顯著增加HSP72含量,而其存活時間及存活率較未運動組顯著增加,TNF-α含量及肺乾溼重比顯著改善,但肺灌洗液白蛋白含量仍無顯著差異,動脈氧分壓顯著增加但動脈二氧化碳分壓則無顯著改變。結論:運動訓練顯著增加及延長第二型糖尿病鼠誘發內毒素血症後的存活率及存活時間,此延長大鼠存活時間、降低肺損傷、維持心臟功能的效果可能與各臟器誘發產生的HSP72有關。
英文摘要 Background and Purpose: Diabetic patients are susceptible to E. coli lipopolysaccharide (LPS) infection, resulting in endotoxemia with cardiopulmonary failure and high mortality rate. We have also demonstrated that heat shock protein-72 can be detected in various organs from normal and type I diabetic rats with exercise training. The purpose of the current study was to characterize effects of exercise preconditioning on endotoxemia-induced cardiopulmonary dysfunction in the rat model of type II diabetes. Methods: Aged 6 weeks male Wistar rat fed 60% fructose-rich chow for 6-8 weeks. When loss of plasma glucose lowering response to tolbutamide were considered as type II diabetes with insulin resistance and randomly assigned to sedentary or exercise groups. The trained rats run gradually on a treadmill 5 days/week, 30-60 min/day with intensity 20-30m/min for 4 weeks. After 24 hrs from the last training session, we compared the temporal profiles of mean arterial pressure, heart rate, cardiac output, and stroke volume of urethane-anesthetized rats after intravenous injection of LPS. At the 4th hour after LPS injection, we determined arterial blood gas, tumor necrosis factor-alpha level in serum and lavage and lung edema. In addition, the HSP72 expression in multiple organs were determined in different groups. Results: After exercise training, we found that HSP72 expression in multiple organs were significantly greater in rats with exercise training than sedentary rats. The survival time was significantly longer in exercised-diabetic rat after administration of LPS. During endotoxemia, prior exercise training could significantly attenuate tumor necrosis factor-alpha level in serum and lavage, diminish the degree of lung edema and prolong the survival time of rats. Conclusions: The current study showed that exercise pretraining prolonged survival time and increased survival rate of fructose-fed diabetic rats after administration of LPS. Clinical Relevance: We provided important information for disclosing the effects of exercise for type II diabetic patients.
論文目次 中文摘要 2
英文摘要 4
縮寫表 7
表目錄 9
圖目錄 10
第一章 緒論 11
第二章 實驗方法及材料 28
第三章 實驗結果 38
第四章 討論 53
第五章 結論 73
參考文獻 75
附表 95
附圖 99
參考文獻 參考文獻
1. Alberti KG and Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetic Medicine 15(7):539-53, 1998.
2. Anderson RE, Tan WK, Martin HS and Meyer FB. Effects of glucose and PaO2 modulation on cortical intracellular acidosis, NADH redox state, and infarction in the ischemic penumbra. Stroke 30(1):160-70, 1999.
3. Angus DC, Linde-Zwirble WT, Clermont G, Ball DE, Basson BR, Ely EW, Laterre PF, Vincent JL, Bernard G, van HB and PROWESS I. Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis. Critical Care Medicine 31(1):1-11, 2003.
4. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J and Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical Care Medicine 29(7):1303-10, 2001.
5. Annane D, Bellissant E and Cavaillon JM. Septic shock. Lancet 365(9453):63-78, 2005.
6. Atalay M, Oksala NK, Laaksonen DE, Khanna S, Nakao C, Lappalainen J, Roy S, Hanninen O and Sen CK. Exercise training modulates heat shock protein response in diabetic rats. Journal of Applied Physiology 97(2):605-11, 2004.
7. Banfi G, Dolci A, Verna R and Corsi MM. Exercise raises serum heat-shock protein 70 (Hsp70) levels. Clinical Chemistry & Laboratory Medicine 42(12):1445-6, 2004.
8. Benfield T, Jensen JS and Nordestgaard BG. Influence of diabetes and hyperglycaemia on infectious disease hospitalisation and outcome. Diabetologia 50(3):549-54, 2007.
9. Bizeau ME and Pagliassotti MJ. Hepatic adaptations to sucrose and fructose. Metabolism: Clinical & Experimental 54(9):1189-201, 2005.
10. Blake MJ, Klevay LM, Halas ES and Bode AM. Blood pressure and heat shock protein expression in response to acute and chronic stress. Hypertension 25(4 Pt 1):539-44, 1995.
11. Bone RC. Let's agree on terminology: definitions of sepsis. Critical Care Medicine 973-976, 1919.
12. Browne JA, Cook C, Pietrobon R, Bethel MA and Richardson WJ. Diabetes and early postoperative outcomes following lumbar fusion. Spine 32(20):2214-9, 2007.
13. Bupha-Intr T and Wattanapermpool J. Cardioprotective effects of exercise training on myofilament calcium activation in ovariectomized rats. Journal of Applied Physiology 96(5):1755-60, 2004.
14. Buras JA, Holzmann B and Sitkovsky M. Animal models of sepsis: setting the stage. Nature Reviews Drug Discovery 4(10):854-65, 2005.
15. Calabrese V, Mancuso C, Sapienza M, Puleo E, Calafato S, Cornelius C, Finocchiaro M, Mangiameli A, Di MM, Stella AM and Castellino P. Oxidative stress and cellular stress response in diabetic nephropathy. Cell Stress & Chaperones 12(4):299-306, 2007.
16. Chen CC, Liu IM and Cheng JT. Improvement of insulin resistance by miracle fruit (Synsepalum dulcificum) in fructose-rich chow-fed rats. Phytotherapy Research 987-992, 2006.
17. Chen HI, Hsieh SY, Yang FL, Hsu YH and Lin CC. Exercise training attenuates septic responses in conscious rats. Medicine & Science in Sports & Exercise 39(3):435-42, 2007.
18. Chien CT, Chen CF, Hsu SM, Lee PH and Lai MK. Protective mechanism of preconditioning hypoxia attenuates apoptosis formation during renal ischemia/reperfusion phase. Transplantation Proceedings 31(5):2012-3, 1999.
19. Chien MY and Wu Y. Insulin Resistance and the Effect of Exercise Training-A Molecular and Cellular Approach. Formosan Journal of Physical Therapy 31(2):130-141 2006.
20. Chuang LM, Tsai ST, Huang BY, Tai TY and DIABCARE (Taiwan) Study Group. The current state of diabetes management in Taiwan. Diabetes Research & Clinical Practice 54 Suppl 1:S55-65, 2001.
21. Chung J, Nguyen AK, Henstridge DC, Holmes AG, Chan MH, Mesa JL, Lancaster GI, Southgate RJ, Bruce CR, Duffy SJ, Horvath I, Mestril R, Watt MJ, Hooper PL, Kingwell BA, Vigh L, Hevener A and Febbraio MA. HSP72 protects against obesity-induced insulin resistance. Proceedings of the National Academy of Sciences of the United States of America 105(5):1739-44, 2008.
22. Ciriello J. Brainstem projections of aortic baroreceptor afferent fibers in the rat. Neuroscience Letters 36(1):37-42, 1983.
23. Cohen J. The immunopathogenesis of sepsis. Nature 420(6917):885-91, -26, 2002.
24. Daugaard M, Rohde M and Jaattela M. The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions. FEBS Letters 581(19):3702-10, 2007.
25. Dauphinee SM and Karsan A. Lipopolysaccharide signaling in endothelial cells. Laboratory Investigation 86(1):9-22, 2006.
26. Demirel HA, Powers SK, Caillaud C, Coombes JS, Naito H, Fletcher LA, Vrabas I, Jessup JV and Ji LL. Exercise training reduces myocardial lipid peroxidation following short-term ischemia-reperfusion. Medicine & Science in Sports & Exercise 30(8):1211-6, 1998.
27. Demirel HA, Powers SK, Naito H and Tumer N. The effects of exercise duration on adrenal HSP72/73 induction in rats. Acta Physiologica Scandinavica 167(3):227-31, 1999.
28. Dyson A, Stidwill R, Taylor V and Singer M. Tissue oxygen monitoring in rodent models of shock. American Journal of Physiology - Heart & Circulatory Physiology 293(1):H526-33, 2007.
29. Dyson A, Stidwill R, Taylor V and Singer M. Tissue oxygen monitoring in rodent models of shock. American Journal of Physiology - Heart & Circulatory Physiology 293(1):H526-33, 2007.
30. Ebihara S, Hussain SN, Danialou G, Cho WK, Gottfried SB and Petrof BJ. Mechanical ventilation protects against diaphragm injury in sepsis: interaction of oxidative and mechanical stresses. American Journal of Respiratory & Critical Care Medicine 165(2):221-8, 2002.
31. Ebihara S, Hussain SN, Danialou G, Cho WK, Gottfried SB and Petrof BJ. Mechanical ventilation protects against diaphragm injury in sepsis: interaction of oxidative and mechanical stresses. American Journal of Respiratory & Critical Care Medicine 165(2):221-8, 2002.
32. Ecochard L, Lhenry F, Sempore B and Favier R. Skeletal muscle HSP72 level during endurance training: influence of peripheral arterial insufficiency. Pflugers Archiv - European Journal of Physiology 440(6):918-24, 2000.
33. Fink MP and Heard SO. Laboratory models of sepsis and septic shock. Journal of Surgical Research 49(2):186-96, 1990.
34. Gabai VL, Meriin AB, Mosser DD, Caron AW, Rits S, Shifrin VI and Sherman MY. Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance. Journal of Biological Chemistry 272(29):18033-7, 1997.
35. Galipeau D, Arikawa E, Sekirov I and McNeill JH. Chronic thromboxane synthase inhibition prevents fructose-induced hypertension. Hypertension 38(4):872-6, 2001.
36. Genuth S, Alberti KG, Bennett P, Buse J, Defronzo R, Kahn R, Kitzmiller J, Knowler WC, Lebovitz H, Lernmark A, Nathan D, Palmer J, Rizza R, Saudek C, Shaw J, Steffes M, Stern M, Tuomilehto J, Zimmet P and Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26(11):3160-7, 2003.
37. Geroulanos S and Douka ET. Historical perspective of the word "sepsis". Intensive Care Medicine 32(12):2077, 2006.
38. Giacca A, Groenewoud Y, Tsui E, McClean P and Zinman B. Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. Diabetes 47(11):1763-70, 1998.
39. Giacconi R, Caruso C, Lio D, Muti E, Cipriano C, Saba V, Boccoli G, Gasparini N, Malavolta M and Mocchegiani E. 1267 HSP70-2 polymorphism as a risk factor for carotid plaque rupture and cerebral ischaemia in old type 2 diabetes-atherosclerotic patients. Mechanisms of Ageing & Development 126(8):866-73, 2005.
40. Gilby KL, Armstrong JN, Currie RW and Robertson HA. The effects of hypoxia-ischemia on expression of c-Fos, c-Jun and Hsp70 in the young rat hippocampus. Brain Research Molecular Brain Research 48(1):87-96, 1997.
41. Hamilton KL, Staib JL, Phillips T, Hess A, Lennon SL and Powers SK. Exercise, antioxidants, and HSP72: protection against myocardial ischemia/reperfusion. Free Radical Biology & Medicine 34(7):800-9, 2003.
42. Harada S, Kamiya K, Masago A, Iwata A and Yamada K. Subarachnoid hemorrhage induces c-fos, c-jun and hsp70 mRNA expression in rat brain. Neuroreport 8(15):3399-404, 1997.
43. Hatanaka N, Kamiike W, Morimoto Y, Shimizu S, Miyata M, Yoshida Y and Matsuda H. Protective effects of feeding and of fructose against hypoxic damage in the perfused liver. Transplantation Proceedings 26(2):916-7, 1994.
44. Hawley JA and Houmard JA. Introduction-preventing insulin resistance through exercise: a cellular approach. Medicine & Science in Sports & Exercise 36(7):1187-90, 2004.
45. Heidemann SM and Glibetic M. Heat stress protects against lung injury in the neutropenic, endotoxemic rat. Inflammation 29(1):47-53, 2005.
46. Hotamisligil GS. Inflammation and metabolic disorders. Nature 444(7121):860-7, 2006.
47. Hotchkiss R, Nunnally I, Lindquist S, Taulien J, Perdrizet G and Karl I. Hyperthermia protects mice against the lethal effects of endotoxin. American Journal of Physiology 265(6 Pt 2):R1447-57, 1993.
48. Hotchkiss RS and Karl IE. The pathophysiology and treatment of sepsis. New England Journal of Medicine 348(2):138-50, 2003.
49. Hung CH, Chang NC, Cheng BC and Lin MT. Progressive exercise preconditioning protects against circulatory shock during experimental heatstroke. Shock 23(5):426-33, 2005.
50. Hung CH, Chen YW, Shao DZ, Chang CN, Tsai YY and Cheng JT. Exercise pretraining attenuates endotoxin-induced hemodynamic alteration in type I diabetic rats. Applied Physiology, Nutrition, & Metabolism = Physiologie Appliquee, Nutrition et Metabolisme 33(5):976-83, 2008.
51. Hwang IS, Ho H, Hoffman BB and Reaven GM. Fructose-induced insulin resistance and hypertension in rats. Hypertension 10(5):512-6, 1987.
52. Jacob A, Steinberg ML, Yang J, Dong W, Ji Y and Wang P. Sepsis-induced inflammation is exacerbated in an animal model of type 2 diabetes. Int J Clin Exp Med 1: 22-31, 2008.
53. Jacober SJ and Sowers JR. An update on perioperative management of diabetes. Archives of Internal Medicine 159(20):2405-11, 1999.
54. Jagadeesha DK, Lindley TE, Deleon J, Sharma RV, Miller F and Bhalla RC. Tempol therapy attenuates medial smooth muscle cell apoptosis and neointima formation after balloon catheter injury in carotid artery of diabetic rats. American Journal of Physiology - Heart & Circulatory Physiology 289(3):H1047-53, 2005.
55. Jesmin S, Gando S, Matsuda N, Sakuma I, Kobayashi S, Sakuraya F and Hattori Y. Temporal changes in pulmonary expression of key procoagulant molecules in rabbits with endotoxin-induced acute lung injury: elevated expression levels of protease-activated receptors. Thrombosis & Haemostasis 92(5):966-79, 2004.
56. Jordan JE, Simandle SA, Tulbert CD, Busija DW and Miller AW. Fructose-fed rats are protected against ischemia/reperfusion injury. Journal of Pharmacology & Experimental Therapeutics 307(3):1007-11, 2003.
57. Joshi N, Caputo GM, Weitekamp MR and Karchmer AW. Infections in patients with diabetes mellitus. New England Journal of Medicine 341(25):1906-12, 1999.
58. Joyeux-Faure M, Rossini E, Ribuot C and Faure P. Fructose-fed rat hearts are protected against ischemia-reperfusion injury. Experimental Biology & Medicine 231(4):456-62, 2006.
59. Kalyanaraman M, Heidemann SM and Sarnaik AP. Macrophage inflammatory protein-2 predicts acute lung injury in endotoxemia. Journal of Investigative Medicine 46(6):275-8, 1998.
60. Kanakura H and Taniguchi T. The antiinflammatory effects of propofol in endotoxemic rats during moderate and mild hypothermia. Journal of Anesthesia 21(3):354-60, 2007.
61. Katsch D. Work therapy for diabetes patients. Erg Physikal Diat The 1: 1-36, 1939.
62. Kavanagh K, Zhang L and Wagner JD. Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys. Cell Stress & Chaperones 14(3):291-9, 2009.
63. Kawamura T, Yoshida K, Sugawara A, Nagasaka M, Mori N, Takeuchi K and Kohzuki M. Impact of exercise and angiotensin converting enzyme inhibition on tumor necrosis factor-alpha and leptin in fructose-fed hypertensive rats. Hypertension Research - Clinical & Experimental 25(6):919-26, 2002.
64. Kiang JG and Tsokos GC. Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacology & Therapeutics 80(2):183-201, 1998.
65. Kim KB, Kim MH and Lee DJ. The effect of exercise in cool, control and hot environments on cardioprotective HSP70 induction. Journal of Physiological Anthropology & Applied Human Science 23(6):225-30, 2004.
66. King H, Aubert RE and Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 21(9):1414-31, 1998.
67. Klaus S, Staubach KH, Heringlake M, Gliemroth J, Schmucker P and Bahlmann L. Tissue metabolism during endotoxin shock after pretreatment with monophosphoryl lipid A. Cardiovascular Research 59(1):105-12, 2003.
68. Koga K, Ogata M, Takenaka I, Matsumoto T and Shigematsu A. Ketamine suppresses tumor necrosis factor-alpha activity and mortality in carrageenan-sensitized endotoxin shock model. Circulatory Shock 44(3):160-8, 1994.
69. Koranyi L, Hegedus E, Peterfal E and Kurucz I. The role of hsp60 and hsp70 kDa heat shock protein families in different types of diabetes mellitus. Orvosi Hetilap 145(9):467-72, 2004.
70. Kotchen TA, Reddy S and Zhang HY. Increasing insulin sensitivity lowers blood pressure in the fructose-fed rat. American Journal of Hypertension 10(9 Pt 1):1020-6, 1997.
71. Kregel KC. Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance. Journal of Applied Physiology 92(5):2177-86, 2002.
72. Kwoun MO, Ling PR, Lydon E, Imrich A, Qu Z, Palombo J and Bistrian BR. Immunologic effects of acute hyperglycemia in nondiabetic rats. Jpen: Journal of Parenteral & Enteral Nutrition 21(2):91-5, -Apr, 1997.
73. Laffey JG, Honan D, Hopkins N, Hyvelin JM, Boylan JF and McLoughlin P. Hypercapnic acidosis attenuates endotoxin-induced acute lung injury. American Journal of Respiratory & Critical Care Medicine 169(1):46-56, 2004.
74. Law WR, Mourelatos MG, Krahmer R, Dziki AJ, Lynch WH and Ferguson JL. Effects of phentolamine or yohimbine on naloxone's actions during endotoxin shock in rats. Shock 7(3):217-24, 1997.
75. Lennon SL, Quindry J, Hamilton KL, French J, Staib J, Mehta JL and Powers SK. Loss of exercise-induced cardioprotection after cessation of exercise. Journal of Applied Physiology 96(4):1299-305, 2004.
76. Li G, Ali IS and Currie RW. Insulin induces myocardial protection and Hsp70 localization to plasma membranes in rat hearts. American Journal of Physiology - Heart & Circulatory Physiology 291(4):H1709-21, 2006.
77. Li JC, Fu CC and Wu DA. The diagnosis and therapy of diabetes mellitus. TZU CHI Medical Journal 18(Suppl 1): 1-9, 2006.
78. Li PL, Chao YM, Chan SH and Chan JY. Potentiation of baroreceptor reflex response by heat shock protein 70 in nucleus tractus solitarii confers cardiovascular protection during heatstroke. Circulation 103(16):2114-9, 2001.
79. Liacos C, Katsaragakis S, Konstadoulakis MM, Messaris EG, Papanicolaou M, Georgiadis GG, Menenakos E, Vasiliadi-Chioti A and Androulakis G. Apoptosis in cells of bronchoalveolar lavage: a cellular reaction in patients who die with sepsis and respiratory failure. Critical Care Medicine 29(12):2310-7, 2001.
80. Ling PR, Mueller C, Smith RJ and Bistrian BR. Hyperglycemia induced by glucose infusion causes hepatic oxidative stress and systemic inflammation, but not STAT3 or MAP kinase activation in liver in rats. Metabolism: Clinical & Experimental 52(7):868-74, 2003.
81. Liu TP, Lee CS, Liou SS, Liu IM and Cheng JT. Improvement of insulin resistance by Acanthopanax senticosus root in fructose-rich chow-fed rats. Clinical & Experimental Pharmacology & Physiology 32(8):649-54, 2005.
82. Liu Y, Lormes W, Baur C, Opitz-Gress A, Altenburg D, Lehmann M and Steinacker JM. Human skeletal muscle HSP70 response to physical training depends on exercise intensity. International Journal of Sports Medicine 21(5):351-5, 2000.
83. Liu Y, Mayr S, Opitz-Gress A, Zeller C, Lormes W, Baur S, Lehmann M and Steinacker JM. Human skeletal muscle HSP70 response to training in highly trained rowers. Journal of Applied Physiology 86(1):101-4, 1999.
84. Locke M, Noble EG and Atkinson BG. Exercising mammals synthesize stress proteins. American Journal of Physiology 258(4 Pt 1):C723-9, 1990.
85. Lopez-Bojorquez LN, Dehesa AZ and Reyes-Teran G. Molecular mechanisms involved in the pathogenesis of septic shock. Archives of Medical Research 35(6):465-79, -Dec, 2004.
86. Maier S, Pajk W, Ulmer H, Hausdorfer H, Torgersen C, Klocker J, Hasibeder W and Knotzer H. Epoprostenol improves mucosal tissue oxygen tension in an acute endotoxemic pig model. Shock 31(1):104-10, 2009.
87. Marti-Carvajal A, Salanti G and Cardona AF. Human recombinant activated protein C for severe sepsis. Cochrane Database of Systematic Reviews (3):CD004388, 2007.
88. Matsuda N, Nishihira J, Takahashi Y, Kemmotsu O and Hattori Y. Role of macrophage migration inhibitory factor in acute lung injury in mice with acute pancreatitis complicated by endotoxemia. American Journal of Respiratory Cell & Molecular Biology 35(2):198-205, 2006.
89. Matz PG, Sundaresan S, Sharp FR and Weinstein PR. Induction of HSP70 in rat brain following subarachnoid hemorrhage produced by endovascular perforation. Journal of Neurosurgery 85(1):138-45, 1996.
90. McCuskey RS, Urbaschek R and Urbaschek B. The microcirculation during endotoxemia. Cardiovascular Research 32(4):752-63, 1996.
91. McMahon MM and Bistrian BR. Host defenses and susceptibility to infection in patients with diabetes mellitus. Infectious Disease Clinics of North America 9(1):1-9, 1995.
92. Merx MW and Weber C. Sepsis and the heart. Circulation 116(7):793-802, 2007.
93. Mikami T, Sumida S, Ishibashi Y and Ohta S. Endurance exercise training inhibits activity of plasma GOT and liver caspase-3 of mice [correction of rats] exposed to stress by induction of heat shock protein 70. Journal of Applied Physiology 96(5):1776-81, 2004.
94. Miller AW, Katakam PV and Ujhelyi MR. Impaired endothelium-mediated relaxation in coronary arteries from insulin-resistant rats. Journal of Vascular Research 36(5):385-92, -Oct, 1999.
95. Milne KJ and Noble EG. Exercise-induced elevation of HSP70 is intensity dependent. Journal of Applied Physiology 93(2):561-8, 2002.
96. Milne KJ, Thorp DB, Melling CW and Noble EG. Castration inhibits exercise-induced accumulation of Hsp70 in male rodent hearts. American Journal of Physiology - Heart & Circulatory Physiology 290(4):H1610-6, 2006.
97. Minuk HL, Vranic M, Marliss EB, Hanna AK, Albisser AM and Zinman B. Glucoregulatory and metabolic response to exercise in obese noninsulin-dependent diabetes. American Journal of Physiology 240(5):E458-64, 1981.
98. Mitaka C, Hirata Y, Yokoyama K, Nagura T, Tsunoda Y and Amaha K. Improvement of renal dysfunction in dogs with endotoxemia by a nonselective endothelin receptor antagonist. Critical Care Medicine 27(1):146-53, 1999.
99. Moran L, Mirault ME, Arrigo AP, Goldschmidt-Clermont M and Tissieres A. Heat shock of Drosophila melanogaster induces the synthesis of new messenger RNAs and proteins. Philosophical Transactions of the Royal Society of London - Series B: Biological Sciences 283(997):391-406, 1978.
100. Nathan DM, Davidson MB, DeFronzo RA, Heine RJ, Henry RR, Pratley R, Zinman B and American Diabetes Association. Impaired fasting glucose and impaired glucose tolerance: implications for care. Diabetes Care 30(3):753-9, 2007.
101. Navarro-Cid J, Maeso R, Perez-Vizcaino F, Cachofeiro V, Ruilope LM, Tamargo J and Lahera V. Effects of losartan on blood pressure, metabolic alterations, and vascular reactivity in the fructose-induced hypertensive rat. Hypertension 26(6 Pt 2):1074-8, 1995.
102. Niess AM, Fehrenbach E, Schlotz E, Sommer M, Angres C, Tschositsch K, Battenfeld N, Golly IC, Biesalski HK, Northoff H and Dickhuth HH. Effects of RRR-alpha-tocopherol on leukocyte expression of HSP72 in response to exhaustive treadmill exercise. International Journal of Sports Medicine 23(6):445-52, 2002.
103. Noble EG, Milne KJ and Melling CW. Heat shock proteins and exercise: a primer. Applied Physiology, Nutrition, & Metabolism = Physiologie Appliquee, Nutrition et Metabolisme 33(5):1050-65, 2008.
104. Noble EG, Moraska A, Mazzeo RS, Roth DA, Olsson MC, Moore RL and Fleshner M. Differential expression of stress proteins in rat myocardium after free wheel or treadmill run training. Journal of Applied Physiology 86(5):1696-701, 1999.
105. O'Brien JM, Jr. and Abraham E. Human models of endotoxemia and recombinant human activated protein C. Critical Care Medicine 32(5 Suppl):S202-8, 2004.
106. Ofenstein JP, Heidemann S, Juett-Wilstermann A and Sarnaik A. Expression of stress proteins HSP 72 & HSP 32 in response to endotoxemia. Annals of Clinical & Laboratory Science 30(1):92-8, 2000.
107. Ogura H, Offner PJ, Saitoh D, Jordan BS, Johnson AA, Pruitt BA, Jr. and Cioffi WG, Jr. The pulmonary effect of nitric oxide synthase inhibition following endotoxemia in a swine model. Archives of Surgery 129(12):1233-9, 1994.
108. Padkin A, Goldfrad C, Brady AR, Young D, Black N and Rowan K. Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Critical Care Medicine 31(9):2332-8, 2003.
109. Palsson-McDermott EM and O'Neill LA. Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology 113(2):153-62, 2004.
110. Park HS, Lee JS, Huh SH, Seo JS and Choi EJ. Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase. EMBO Journal 446-456, 1920.
111. Parker SJ and Watkins PE. Experimental models of gram-negative sepsis. British Journal of Surgery 88(1):22-30, 2001.
112. Paroo Z, Tiidus PM and Noble EG. Estrogen attenuates HSP 72 expression in acutely exercised male rodents. European Journal of Applied Physiology & Occupational Physiology 80(3):180-4, 1999.
113. Pass LJ, Schloerb PR, Pearce FJ and Drucker WR. Cardiopulmonary response of the rat to gram-negative bacteremia. American Journal of Physiology 246(3 Pt 2):H344-50, 1984.
114. Paulsen G, Vissing K, Kalhovde JM, Ugelstad I, Bayer ML, Kadi F, Schjerling P, Hallen J and Raastad T. Maximal eccentric exercise induces a rapid accumulation of small heat shock proteins on myofibrils and a delayed HSP70 response in humans. American Journal of Physiology - Regulatory Integrative & Comparative Physiology 293(2):R844-53, 2007.
115. Plachinta RV, de Klaver MJ, Hayes JK and Rich GF. The protective effect of protein kinase C and adenosine triphosphate-sensitive potassium channel agonists against inflammation in rat endothelium and vascular smooth muscle in vitro and in vivo. Anesthesia & Analgesia 99(2):556-61, table of contents, 2004.
116. Plante GE, Perreault M, Lanthier A, Marette A and Maheux P. Reduction of endothelial NOS and bradykinin-induced extravasation of macromolecules in skeletal muscle of the fructose-fed rat model. Cardiovascular Research 59(4):963-70, 2003.
117. Porta F, Takala J, Kolarova A, Ma Y, Redaelli CA, Brander L, Bracht H and Jakob SM. Oxygen extraction in pigs subjected to low-dose infusion of endotoxin after major abdominal surgery. Acta Anaesthesiologica Scandinavica 49(5):627-34, 2005.
118. Powers SK, Demirel HA, Vincent HK, Coombes JS, Naito H, Hamilton KL, Shanely RA and Jessup J. Exercise training improves myocardial tolerance to in vivo ischemia-reperfusion in the rat. American Journal of Physiology 275(5 Pt 2):R1468-77, 1998.
119. Preiser JC, Sun Q, Hadj-Sadok D and Vincent JL. Differential effects of a selective inhibitor of soluble guanylyl cyclase on global and regional hemodynamics during canine endotoxic shock. Shock 465-468, 2003.
120. Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS and Wenzel RP. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA 273(2):117-23, 1995.
121. Rinaldi B, Corbi G, Boccuti S, Filippelli W, Rengo G, Leosco D, Rossi F, Filippelli A and Ferrara N. Exercise training affects age-induced changes in SOD and heat shock protein expression in rat heart. Experimental Gerontology 41(8):764-70, 2006.
122. Ritossa F. A new puffing pattern induced by temperature shock and DNP in drosophila. Cellular and Molecular Life Sciences18(12): 571-573 18: 571-573, 19620.
123. Rosen P, Ohly P and Gleichmann H. Experimental benefit of moxonidine on glucose metabolism and insulin secretion in the fructose-fed rat. Journal of Hypertension - Supplement 15(1):S31-8, 1997.
124. Rosselet A, Feihl F, Markert M, Gnaegi A, Perret C and Liaudet L. Selective iNOS inhibition is superior to norepinephrine in the treatment of rat endotoxic shock. American Journal of Respiratory & Critical Care Medicine 157(1):162-70, 1998.
125. Ruetten H, Thiemermann C and Vane JR. Effects of the endothelin receptor antagonist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rat. British Journal of Pharmacology 118(1):198-204, 1996.
126. Ryan AJ, Flanagan SW, Moseley PL and Gisolfi CV. Acute heat stress protects rats against endotoxin shock. Journal of Applied Physiology 73(4):1517-22, 1992.
127. Sakaguchi S and Furusawa S. Oxidative stress and septic shock: metabolic aspects of oxygen-derived free radicals generated in the liver during endotoxemia. FEMS Immunology & Medical Microbiology 47(2):167-77, 2006.
128. Saltiel AR. Series introduction: the molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases. Journal of Clinical Investigation 106(2):163-4, 2000.
129. Shah BR and Hux JE. Quantifying the risk of infectious diseases for people with diabetes. Diabetes Care 26(2):510-3, 2003.
130. Shimamoto K and Ura N. Mechanisms of insulin resistance in hypertensive rats. Clinical & Experimental Hypertension (New York) 28(6):543-52, 2006.
131. Singh S and Evans TW. Organ dysfunction during sepsis. Intensive Care Medicine 32(3):349-60, 2006.
132. Stanhope KL and Havel PJ. Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance. Current Opinion in Lipidology 16-24, 1919.
133. Starkie R, Ostrowski SR, Jauffred S, Febbraio M and Pedersen BK. Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. FASEB Journal 17(8):884-6, 2003.
134. Starnes JW, Choilawala AM, Taylor RP, Nelson MJ and Delp MD. Myocardial heat shock protein 70 expression in young and old rats after identical exercise programs. Journals of Gerontology Series A-Biological Sciences & Medical Sciences 60(8):963-9, 2005.
135. Stewart TE, Valenza F, Ribeiro SP, Wener AD, Volgyesi G, Mullen JB and Slutsky AS. Increased nitric oxide in exhaled gas as an early marker of lung inflammation in a model of sepsis. American Journal of Respiratory & Critical Care Medicine 151(3 Pt 1):713-8, 1995.
136. Taniguchi T, Kanakura H, Takemoto Y and Yamamoto K. The antiinflammatory effects of ketamine in endotoxemic rats during moderate and mild hypothermia. Anesthesia & Analgesia 98(4):1114-20, 2004.
137. Taniguchi T, Kidani Y, Kanakura H, Takemoto Y and Yamamoto K. Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats. Critical Care Medicine 32(6):1322-6, 2004.
138. Taniguchi T, Kurita A, Kobayashi K, Yamamoto K and Inaba H. Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats. Journal of Anesthesia 22(3):221-8, 2008.
139. Taniguchi T, Shibata K and Yamamoto K. Ketamine inhibits endotoxin-induced shock in rats. Anesthesiology 95(4):928-32, 2001.
140. Taniguchi T, Takemoto Y, Kanakura H, Kidani Y and Yamamoto K. The dose-related effects of ketamine on mortality and cytokine responses to endotoxin-induced shock in rats. Anesthesia & Analgesia 97(6):1769-72, 2003.
141. Taniguchi T, Takemoto Y, Tsuda K, Inaba H and Yamamoto K. Effects of post-treatment with direct hemoperfusion using a CTR column on mortality and inflammatory responses to endotoxin-induced shock in rats. Blood Purification 24(5-6):460-4, 2006.
142. Thomas JR, Harlan JM, Rice CL and Winn RK. Role of leukocyte CD11/CD18 complex in endotoxic and septic shock in rabbits. Journal of Applied Physiology 73(4):1510-6, 1992.
143. Thorburn AW, Storlien LH, Jenkins AB, Khouri S and Kraegen EW. Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats. American Journal of Clinical Nutrition 49(6):1155-63, 1989.
144. Thorp DB, Haist JV, Leppard J, Milne KJ, Karmazyn M and Noble EG. Exercise training improves myocardial tolerance to ischemia in male but not in female rats. American Journal of Physiology - Regulatory Integrative & Comparative Physiology 293(1):R363-71, 2007.
145. Tu YY and Sheu WH. Dysglycemia and Cardiovascular Disease. Journal of Internal Medicine of Taiwan 2008.
146. Villar J, Ribeiro SP, Mullen JB, Kuliszewski M, Post M and Slutsky AS. Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model. Critical Care Medicine 22(6):914-21, 1994.
147. Vincent HK, Powers SK, Stewart DJ, Shanely RA, Demirel H and Naito H. Obesity is associated with increased myocardial oxidative stress. International Journal of Obesity & Related Metabolic Disorders: Journal of the International Association for the Study of Obesity 23(1):67-74, 23: 67-74, 1999.
148. Wakayama F, Fukuda I, Suzuki Y and Kondo N. Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model. Annals of Thoracic Surgery 83(1):153-60, 2007.
149. Walsh RC, Koukoulas I, Garnham A, Moseley PL, Hargreaves M and Febbraio MA. Exercise increases serum Hsp72 in humans. Cell Stress & Chaperones 6(4):386-93, 2001.
150. Wannamethee SG, Lowe GD, Shaper AG, Rumley A, Lennon L and Whincup PH. Insulin resistance, haemostatic and inflammatory markers and coronary heart disease risk factors in Type 2 diabetic men with and without coronary heart disease. Diabetologia 47(9):1557-65, 2004.
151. Watowich SS and Morimoto RI. Complex regulation of heat shock- and glucose-responsive genes in human cells. Molecular & Cellular Biology 8(1):393-405, 1988.
152. Wei M, Gibbons LW, Mitchell TL, Kampert JB, Lee CD and Blair SN. The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men. Annals of Internal Medicine 130(2):89-96, 1999.
153. Wei Y, Wang D, Topczewski F and Pagliassotti MJ. Fructose-mediated stress signaling in the liver: implications for hepatic insulin resistance. Journal of Nutritional Biochemistry 18(1):1-9, 2007.
154. Wheeler AP and Bernard GR. Treating patients with severe sepsis. New England Journal of Medicine 340(3):207-14, 1999.
155. Wheeler DS and Wong HR. Heat shock response and acute lung injury. Free Radical Biology & Medicine 42(1):1-14, 2007.
156. Winnick JJ, Sherman WM, Habash DL, Stout MB, Failla ML, Belury MA and Schuster DP. Short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole-body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivity. Journal of Clinical Endocrinology & Metabolism 93(3):771-8, 2008.
157. Yabunaka N, Ohtsuka Y, Watanabe I, Noro H, Fujisawa H and Agishi Y. Elevated levels of heat-shock protein 70 (HSP70) in the mononuclear cells of patients with non-insulin-dependent diabetes mellitus. Diabetes Research & Clinical Practice 30(2):143-7, 1995.
158. Yamagishi N, Nakayama K, Wakatsuki T and Hatayama T. Characteristic changes of stress protein expression in streptozotocin-induced diabetic rats. Life Sciences 69(22):2603-9, 2001.
159. Zhuo H, Ichikawa H and Helke CJ. Neurochemistry of the nodose ganglion. Progress in Neurobiology 52(2):79-107, 1997.
160. Zimmet P, Alberti KG and Shaw J. Global and societal implications of the diabetes epidemic. Nature 414(6865):782-7, 2001.
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