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系統識別號 U0026-0812200915251335
論文名稱(中文) 利用異質接面高分子於光介電泳晶片操控微粒子
論文名稱(英文) Bulk-heterojunction polymers in optically-induced dielectrophoretic devices for the manipulation of microparticles
校院名稱 成功大學
系所名稱(中) 工程科學系碩博士班
系所名稱(英) Department of Engineering Science
學年度 97
學期 2
出版年 98
研究生(中文) 王瑋
研究生(英文) Wei Wang
電子信箱 willymailbox@gmail.com
學號 N9696435
學位類別 碩士
語文別 中文
論文頁數 69頁
口試委員 指導教授-李國賓
口試委員-楊瑞珍
指導教授-郭宗枋
中文關鍵字 異質接面高分子  光介電泳  微機電系統 
英文關鍵字 optically-induced dielectrophoresis(ODEP)  bulk-heterojunction polymer  Micro-Electro-Mechanical System(MEMS) 
學科別分類
中文摘要 此篇論文利用高分子當作為光介電泳晶片的材料,應用在相關的細胞及奈米微珠的操控中,其中研究的主題包含了材料光電轉換機制,晶片製程參數及晶片效能提升。首先,文中以一個嶄新的材料來針對光介電泳晶片製造上的改良,可以利用移動式的光之圖形操控微粒子或細胞。光的主動層個結構是由P3HT/PCBM所構成的異質接面的高分子薄膜。當以一投影機光源照射至單層異質接面結構之材料表面時,此時因為電子施體(Donor)-受體(Acceptor)間之接觸面積較大,當材料吸收光能轉換為激發子(exitcon)後,能有效被分離成電子與電洞(dissociation),在主動層中的電子與電洞將引致不均勻電場來對細胞或微粒子進行操控。用投影機光源之投影圖像在異質接面高分子介電泳晶片,所誘發產生之虛擬電極將可用來對生物體進行操控,同時也針對高分子膜層結構及高分子膜厚對整體效能進行分析及研究研究,當厚度達最大值497nm時(5wt%, 600rpm),最大拖曳速度為202 µm/s,同時,所誘發之DEP力量亦達最大值38.2 pN 。晶片最大效能在操控350分鐘時仍呈現穩定之DEP力量大小。本研究提供一種新型高分子薄膜試片。以往非晶矽基板受限於複雜的製程,現在高分子薄膜晶片不僅成本低且在低溫下具有快速生產的潛質,若配合便宜的塑膠基板或可撓曲式(flexible)基板以取代傳統的玻璃基板,並輔以噴墨壓印技術快速生產,其成本上的絕對優勢使此基板能以可拋棄式的型態使用於生物的應用上。
英文摘要 This paper presents a new material for fabricating optically-induced dielectrophoretic (ODEP) devices, which can manipulate microparticles or cells by using moving light patterns. A thin film of a bulk-heterojunction (BHJ) polymer, a mixture of regioregular poly(3-hexylthiophene) and [6,6]-phenyl C61-butyric acid methyl ester, is used as a light-activated layer. When illuminated by a projected light beam, the photo-induced charge carriers created by the electron transfer of excitons at a donor/acceptor interface in the BHJ layer, disturbs the uniformly-distributed electric field applied on the ODEP devices. A negative DEP force is then generated by virtual electrodes defined by the optical images from a computer-programmable projector to manipulate microparticles, thus providing a flexible platform for particle manipulation. The effect of the polymer thickness and composition on the magnitude of the generated DEP force has been extensively investigated. The maximum particle velocity and the drag force applied on 20 m diameter polystyrene beads are measured to be around 202 m/s and 38.2 pN, respectively, for a device with a 497-nm thick BHJ layer. The lifetime of the developed device is also explored. This BHJ polymer may provide a promising candidate for future ODEP devices capable of nanoparticle and cell manipulation. The amorphous silicon substrate was constrained by its complex manufacture procedure. On the contrary, the polymer thin film chip can be spin-coated at a relatively low temperature for mass production of the ODEP chips. It is also feasible to fabricate the ODEP device on large-area and flexible polymer substrates through a continuous roll-to-roll coating process. Furthermore, the low-cost advantage enables the chips to be disposable in biological applications.
論文目次 摘要….…………………………………………………………………I
Abstract ……………………………………………………………III
致謝……………………………………………………………………V
目錄……………………………………………………………………VI
圖目錄…………………………………………………………………IX
符號與縮寫……………………………………………………………XII
第一章 序論…………………………………………………………1
1-1 前言 ……………………………………………………………1
1-2 生物微機電系統 ………………………………………………1
1-3 介電泳效應………………………………………………………2
1-4 光介電泳操控原理………………………………………………5
1-5 無機光導層之製備………………………………………………7
1-6 研究動機…………………………………………………………8
1.7 本文架構………………………………………………………10
第二章、異質接面高分子材料理論………………………………15
2-1 前言……………………………………………………………15
2-2 共軛高分子起源 ………………………………………………15
2-3 共軛高分子之能階圖…………………………………………16
2-4 載子傳遞的機制 ………………………………………………17
2-5 共軛高分子材料的起源與發展………………………………18
2-6 異質接面高分子材料的起源與發展…………………………19
2-7 異質接面高分子工作原理……………………………………19
2-8 電子予體與電子受體的材料………………………………21
2-9 電洞修飾層材料 ………………………………………………24
2-10 高分子與非晶矽之工作原理與特性分析…………………26
第三章、新穎高分子薄膜材料應用於光介電泳晶片之設計及實驗架設……………………………………………………………………31
3-1 前言 …………………………………………………………31
3-2 實驗部分……………………………………………………31
3-3 導電玻璃清洗………………………………………………32
3-4 高分子材料溶液配置………………………………………33
3-5 電動收集層之塗佈…………………………………………34
3-6 P3HT:PCBM薄膜表面結晶……………………………………34
3-7 絕水氧層之熱蒸鍍…………………………………………35
3-8 晶片上下板黏合封裝………………………………………36
3-9 實驗架設………………………………………………………36
第四章、異質接面高分子光介電泳晶片效能分析………………44
4-1 晶片介電泳力大小之定義……………………………………44
4-2 異質接面光主動層材料之特性………………………………45
4-3 光主動層厚度與光學吸收之關係…………………………46
UV-Vis圖譜………………………………………………………47
4-4主動層厚度與介電泳力大小之關係…………………………48
4-5 主動層厚度與絕水層與否之使用壽命關係…………………48
4-6 聚苯乙烯微珠操控……………………………………………49
4-7 材料吸收曲線分布與投影機光譜圖之關係…………………50
4-8 不同色光及光電特性分析……………………………………51
4-9 不同色光及介電泳力量大小分析……………………………52
4-10 細胞操控………………………………………………………53
4-11 異質接面高分子光介電泳晶片之優勢………………………53
4-12 結論 ……………………………………………………………54
第五章、結論與未來展望……………………………………………61
5-1 結論………………………………………………………………61
5-2 未來展望…………………………………………………………62
參考文獻………………………………………………………………63
自述……………………………………………………………………68
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