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系統識別號 U0026-0812200915071574
論文名稱(中文) 體外震波消脂術之動物實驗
論文名稱(英文) Animal Experiment of Extracorporeal Shock Wave Lipotripsy
校院名稱 成功大學
系所名稱(中) 航空太空工程學系碩博士班
系所名稱(英) Department of Aeronautics & Astronautics
學年度 97
學期 1
出版年 98
研究生(中文) 鄭匡復
研究生(英文) Kuang-Fu Zheng
電子信箱 p4695144@mail.ncku.edu.tw
學號 p4695144
學位類別 碩士
語文別 中文
論文頁數 78頁
口試委員 指導教授-梁勝明
指導教授-溫志湧
口試委員-張建成
口試委員-馬亞尼
口試委員-顏經州
中文關鍵字 病理檢驗  體外震波  能量強度  消脂術  動物實驗 
英文關鍵字 Animal experiment  Lipotripsy  energy intensity  Extracorporeal Shock Wave  Pathological examination 
學科別分類
中文摘要   體外震波消脂術是運用體外震波聚焦在脂肪細胞內,將震波所產生的空蝕現象來破壞脂肪組織。由體內的酵素分解這些被破壞的脂肪細胞,再經由循環系統將這些脂肪代謝出體外或是再吸收利用,而使得我們的聚焦區也就是我們希望消脂的區域內脂肪細胞大量減少達到消脂的目的。
  本研究首先使用PVDF壓力探針測量10kV的電壓所擊發的體外震波在水中以及在脂肪中的壓力波型,再利用積分程式計算出能量強度。之後,使用六月齡雄性紐西蘭大白兔和二月齡LY品系的公豬做為本研究的實驗動物,使用電壓10kV的震波聚焦在實驗動物的脂肪區域中。在震波試驗後,觀察實驗動物的生理情形以及副作用,並犧牲實驗動物取下檢體進行病理檢驗、切片染色,並用顯微鏡觀察證明震波對於實驗動物脂肪的破壞情形。在動物實驗中可以證明震波空蝕效應的能量確實可以破壞生物體內的脂肪細胞,但是同時也會造成一些輕微的副作用如輕微的出血。還有發現以10kV的震波操作電壓擊發震波六百次和震波的聚焦區域內0.112 之高能量密度,即可造成實驗動物內脂肪細胞受到傷害,而此結果可做為未來臨床實驗之參考。
英文摘要 Extracorporeal shock wave lipotripsy is a technology that applies extracorporeal shock wave focusing on an adipose tissue to destroy adipose cells by effects of shock-wave compression and micro-jets from cavitation. The damaged adipose cells are decomposed by body’s enzyme. The circulatory system re-digests or metabolizes the damaged adipose cells. As a result, unwanted fat cells disappear by the non-invasive method.
In this study, a PVDF pressure sensor was used to detect the focused shock form and to measure the focused pressure in water and in adipose tissue at an operation voltage of 10kV. The corresponding energy intensity was calculated. Six-month-old male rabbits of New Zealand breed and two-month-old male pigs of LY breed were used for experiment. After shock wave administration on the chosen adipose tissue of experimental animals, we inspected animal’s physiological conditions and side effects by eyes. After examination, the tested animal was sacrificed and was taken for pathological examination and slice staining. Finally we confirmed the shock wave destruction on the sample by a microscope. Though animal experiments, the energy of shock waves needed for destroying adipose cells was determined. During animal experiments, it was found that a little side effect like slight bleeding was inevitable. Moreover, it was found that 600 shock-wave firings with 10kV voltage setting can damage fat cells, resulting in an energy intensity of 0.112 in the focal area. This result can serve as a reference for future clinical experiments.
論文目次 中文摘要........................................................................................................ i
英文摘要....................................................................................................... ii
致謝.............................................................................................................. iii
目錄.............................................................................................................. iv
表目錄.......................................................................................................... vi
圖目錄......................................................................................................... vii
符號說明...................................................................................................... xi
第一章 緒論 1
§1-1 前言 1
§1-2 研究動機與目的 1
§1-3 文獻回顧 2
第二章 理論分析 5
§2-1 震波基本原理 5
§2-1-1 球震波之基本特性 6
§2-1-2 電水式震波產生器 8
§2-1-3 空蝕現象 10
§2-2 脂質與肥胖 11
§2-3 壓力波型與能量強度計算 13
第三章 實驗設備方法、與步驟 16
§3-1 實驗設備 16
§3-1-1 體外震波碎石機 19
§3-1-2 壓力量測系統 21
§3-1-3 資料擷取系統 22
§3-2 實驗方法 23
§3-2-1 橢圓反射體之物理第二焦點尋找 23
§3-2-2 實驗動物 24
§3-2-2動物實驗之手術器材、藥品與其他輔助工具 27
§3-3 實驗目的與步驟 28
§3-3-1 壓力量測部份 28
§3-3-2 動物實驗部份 28
§3-3-3 檢驗方法 31
第四章 結果與討論 33
§4-1 震波參數 33
§4-2 震波能量強度 34
§4-3 動物實驗 42
§4-3-1 巨觀檢驗結果 42
§4-3-2 微觀檢驗結果 53
§4-3-3 震波對脂肪傷害評估 66
§4-4 副作用分析 67
第五章 結論與建議 71
§5-1 結論 71
§5-2 未來工作與建議 72
參考文獻 74
附錄 計算能量強度積分程式 77
自述 78
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