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系統識別號 U0026-0812200912093601
論文名稱(中文) 長期跑步機運動對大鼠被動逃避學習行為的影響-探討血清素系統所扮演的可能角色
論文名稱(英文) Effects of Chronic Treadmill Exercise on Passive Avoidance Task in Rats -Possible Roles of Serotonergic System
校院名稱 成功大學
系所名稱(中) 生理學研究所
系所名稱(英) Department of Physiology
學年度 94
學期 2
出版年 95
研究生(中文) 林俐君
研究生(英文) Li-Chun Lin
學號 s3693402
學位類別 碩士
語文別 英文
論文頁數 70頁
口試委員 指導教授-陳洵瑛
口試委員-黃阿敏
召集委員-游一龍
中文關鍵字 1A/2A亞型受體  跑步機運動  恐懼記憶  血清素 
英文關鍵字 treadmill exercise  serotonin  fear memory  HTR1A/HTR2A 
學科別分類
中文摘要   從過去研究已知運動能促進腦功能,其中包括神經可塑性及大腦的學習記憶功能。雖然已知在調控恐懼記憶中,杏仁核及血清素扮演重要的角色,但對於運動所促進恐懼記憶的機制中,血清素系統是否參與,至今尚未有明確的證據。因此,本研究藉由雄性大鼠給予四星期的跑步機中度運動訓練方式,來探討被動逃避學習行為受到長期運動訓練的變化,並測量腦中前額葉,海馬迴及杏仁核區域的血清素1A,2A亞型受體,血清素轉運子的蛋白質表現量,及各腦區血清素及其代謝物的濃度。此外更近一步以藥理方式探討血清素系統在運動促進恐懼記憶所扮演的角色。研究結果發現 (1) 長期跑步機運動訓練提升了足部電極刺激24小時之後的被動逃避學習行為; (2) 藉由西方點墨法得知長期運動訓練降低杏仁核之血清素1A,2A亞型受器的蛋白質表現量; 然而,在前額葉及海馬迴的腦區中,其表現量並不受運動訓練影響; 血清素轉運子的蛋白質表現量亦不受影響; (3)長期跑步機運動訓練降低海馬迴中的血清素濃度; (4) 在被動逃避學習行為測驗中,預處理全身性注射血清素1A亞型受體作用劑 (8-OH-DPAT)和促血清素釋放複合物 (PCA) 會損害恐懼記憶學習表現,但在運動組中只有8-OH-DPAT的全身性注射預處理會損害恐懼記憶。此外,藉由熱板測試評估顯示,血清素藥物預處理並不會造成痛覺敏感度改變。所以,以上結果暗示長期跑步機運動訓練向下調整杏仁核中的血清素1A亞型受體可能參與運動促進恐懼記憶的分子生物機制。

英文摘要   It is known that exercise has beneficial effects on brain functions, including neural plasticity and learning and memory, and that amygdala and serotonin (5-HT) system play critical roles in regulating fear memory. However, whether exercise-enhanced fear memory is regulated at least in part by serotonin system is still unknown. Therefore, we examined step-through passive avoidance, and levels of 5-HT and its metabolite (5-HIAA), protein expression of 5-HT1A, 5-HT2A receptors and 5-HT transporter in related brain regions, including prefrontal cortex, hippocampus, and amygdala, after 4-wk compulsive treadmill running in male Sprague-Dawley rats. The role of serotonergic system in exercise-enhanced avoidance task was further investigated by pharmacological approaches. Our results demonstrated that (1) treadmill exercise training enhanced passive avoidance learning performance 24h after passive avoidance training; (2) exercise decreased 5-HT1A and 5-HT2A receptors protein expression, determined by Western blotting, in the right amygdala, but not in the prefrontal cortex and hippocampus. In addition, the expression of 5-HT transporter protein remained unaltered after exercise; (3) treadmill exercise decreased 5-HT levels, measured by HPLC, in the hippocampus; (4) pretreatment of the selective 5-HT1A receptor agonist (8-OH-DPAT) and the 5-HT releasing compound (PCA) impaired passive avoidance performance, but only the administration of 8-OH-DPAT abolish exercise-enhanced fear memory. In addition, the pretreatment of 5-HT drugs did not produce a significant change in pain sensitivity, assessed by hot-plate test. The results suggest that down-regulation of 5-HT1A receptor may be involved in exercise-enhanced fear memory. Whether the reduction of 5-HT1A and 5-HT2A receptors expression in amygdala is involved in the beneficial effects of physical activity on fear memory will be further clarified.

論文目次 Table of contents
Section Content Page

Abstract in Chinese I
Abstract III
Acknowledgments………………………………… IV
Table of Contents………………………………………… V
List of Figures………………………………………… .VIII
Abbreviations…………………………… …..X

1.0 Introduction

1.1 Exercise and learning/memory……………………………..1
1.2 Serotonin system…………………………………………....1
1.3 Exercise on serotonin system………………………… ….3
1.3.1 Serotonin synthesis.................................3
1.3.2 Acute exercise on serotonin system………………...3
1.3.3 Chronic exercise on serotonin levels……… …….4
1.3.4 Exercise on 5-HT receptor system……..…………….5
1.4 Fear memory………………………………………..… …….6
1.4.1 Role of serotonin in fear memory………… ………..6
1.4.2 Role of serotonin receptors in fear memory…… …7
Aim………………………………………………..………..…… ….10
Research Questions………………………………………………………11
Significance………………………………………………… ………… 12
2.0 Materials and methods
Animals…………………………………………………… …………… 13
Reagents………………………………………………….... 13
Exercise training protocol………………………………….14
Citrate synthesis assay……………………………………...15
Surgery……………………………………………………...15
Histological verification…………………………………….16
Serotonin drugs administration……………………………..16
Step-through passive avoidance task………………………..17
Hot plate test………………………………………………..18
Tissue preparation…………………………………………..19
Protein determination……………………………………….19
Western blot analysis………………………………………..19
Double immunofluorescence staining………………………21
High performance liquid chromatography(HPLC) analysis...22
Statistical analysis……………………………………………23

3.0 Results
Effect of 4-wk treadmill exercise on the citrate synthesis activity
in soleus muscles……………………….………………..……………...24
Effects of 4-wk treadmill exercise on memory retention in step-through
passiveavoidance task…………………………………………………...24
Effects of 4-wk treadmill exercise on serotonin level………………….….25
Effects of exercise training on the expression of serotonin receptors……..25
Effects of pre-training systemic injection of HTR1A agonist and 5-HT
releasing compound on retention of passive avoidance task in control group……………………………………………………………………..26
Effects of pretraining systemic injection of HTR1A agonist and 5-HT releasing compound on retention of passive avoidance task in exercise group…………………………………………………………….…….....27
Effect of pretraining systemic injection of HTR1A agonist (8-OH-DPAT) and 5-HT releasing compound (PCA) in hot plate test………………………27
Effects of post-training intra-amygdala injection of HTR1A agonist……...28

4.0 Discussion 29

5.0 Conclusion 38

6.0 References 39

7.0 Appendix

A.1 The classifications of 5-HT receptors…………………………...67
A.2 Model of the serotonergic system at rest and…………………....68
during prolonged exercise
A.3 The circuitry of amygdala and its interactions with……………..69
other brain structures in fear memory

8.0 About the author………………………………………………….70
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