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系統識別號 U0026-0812200910241557
論文名稱(中文) 長期疲勞症候群患者執行持續性認知作業的 量化腦波及行為表現
論文名稱(英文) The performance and quantitative EEG on continuous cognitive tasks in patients with chronic fatigue syndrome
校院名稱 成功大學
系所名稱(中) 行為醫學研究所
系所名稱(英) Institute of Behavioral Medicine
學年度 90
學期 2
出版年 91
研究生(中文) 謝明慧
研究生(英文) Ming-Hui Hsieh
學號 s8688108
學位類別 碩士
語文別 中文
論文頁數 75頁
口試委員 召集委員-謝毅興
指導教授-游一龍
口試委員-楊建銘
中文關鍵字 長期疲勞症候群  量化腦波  持續性認知作業 
英文關鍵字 CFS  continuous cognitive task  QEEG 
學科別分類
中文摘要 中文摘要

研究目的:過去研究指出長期疲勞症候群(Chronic Fatigue Syndrome, CFS)的個案在認知功能上的主要問題可能在於訊息處理功能的缺損及處理速度不足,而影響了個案的記憶力及注意力功能,但也有相當不一致的研究結果,同時缺乏直接觀察CFS個案在執行認知作業的過程中大腦活動狀態的研究,因此無法了解CFS個案認知功能缺損的原因及內在能量的運用情形。本研究主要是利用Quantitative EEG (QEEG) 來測量CFS個案在執行持續性的認知作業的過程中,腦部活動及能量運用的變化,藉此了解CFS個案在執行長時間的認知作業時所呈現的行為表現及腦部活動的現象,進一步能夠了解CFS個案認知功能缺損及容易疲倦的可能原因。方法:本研究共收了12個CFS個案,12個健康控制組,使用警覺性測驗、高難度及低難度運作記憶作業為工具。在作業進行過程中除了記錄個案的反應時間、正確與否等行為表現,同時也持續測量個案的腦波。另外,在測驗前後皆請個案填寫情緒評量表,也分別測量六分鐘的resting EEG。結果:研究分析結果顯示,CFS個案在執行低難度運作記憶作業時的反應時間較控制組長,但其正確率並無明顯問題,而其腦波呈現出CFS個案一開始維持較高的警覺度,但也很快呈現疲勞的現象,此外,控制組的反應時間上呈現明顯的學習效果及疲勞或無聊效果,但CFS個案卻無這樣的表現。在高難度的作業表現上,CFS個案在反應錯誤率上比控制組低,但腦波變化並無不同的表現。CFS個案和控制組個案在警覺性作業的行為表現及腦波變化則無明顯不同。另外,CFS個案在一段長時間熟悉作業後,主觀的緊張程度仍明顯增加。整體而言,CFS個案在處理訊息的過程中,似乎維持了較高的警覺性,而未有效地運用內在能量,這可能是造成CFS個案在進行一些花費心力的工作後容易疲勞的原因。
英文摘要 Abstract
Objective: The purpose of this study was to explore the pattern of inner resources utilization while doing continuous cognitive tasks in chronic fatigue syndrome (CFS) patients, in order to understand the cognitive impairments and the phenomenon of fatigue in these patients. Methods: Twelve CFS subjects and twelve healthy control subjects participated in this study. Their reaction time and EEG were recorded when they were performing an easy and a difficult version of working memory tasks, and a vigilance task. Also, 6 minutes of resting EEG were collected for all subjects and they were asked to complete a mood visual analogue scale before and after doing all the tasks. Results: When performing the easy version of working memory task, CFS subjects had longer reaction time but same omission and commission rate. When the task were divided into 4 segments over time, the average reaction time in healthy control subjects showed a learning effect as well as a boredom or fatigue effect, which were not present in CFS group. For the EEG measures, CFS subjects had higher arousal level even while performing the easy version of working memory task, but showed EEG pattern of fatigue level sooner. In difficult version of working memory, CFS subjects had lower commission rate than control subjects had, but there were no differences in EEG pattern. After performing all the tasks, CFS subjects rated their subjective anxiety level higher than in the beginning of all the tasks. In contrast, control subjects showed a decline in their level of anxiety. Conclusion: Behaviorally, CFS patients tend to maintain a constant level of performance, disregarding the increase in familiarity with the task. However, EEG data indicated earlier sign of fatigue and increased level of arousal in CFS patients. The results suggested a defect in the utilization of inner resources in CFS patients. They strive to maintain a constant level of performance and lack of the flexibility to modulate their mental efforts according to outside situation. This might contribute to their reported fatigue and impaired cognitive function.
論文目次 目錄

中文摘要 ………………………………….. 1-2
英文摘要 ………………………………….. 3-4
誌謝 ………………………………….. 5-6
目錄 ………………………………….. 7
表目錄 ………………………………….. 8-10
圖目錄 ………………………………….. 11
序論 ………………………………….. 12-20
方法 ………………………………….. 21-28
結果 ………………………………….. 29-42
討論 ………………………………….. 43-47
結果圖表 ………………………………….. 48-68
參考文獻 ………………………………….. 69-75


表目錄

表一 個案年齡、教育年數的平均數(標準差)
、性別比例的統計結果…………………………………………………48
表二 執行運作記憶作業不同時間點的平均反應時間(標準差)
及統計結果(以秒為單位) ……………………………………..49
表三 執行運作記憶作業時不同時間點反應遺漏率
(omission rate)的平均數(標準差)及統計結………………..50
表四 執行運作記憶作業時不同時間點的反應錯誤率
(commission rate)平均數(標準差)及統計結果…………….51
表五 執行運作記憶作業時不同時間點log alpha power
平均數(標準差)及統計結果……………………………….52
表六 執行運作記憶作業時不同時間點log beta2 power
的平均數(標準差)及統計結果…………………………….53
表七 執行運作記憶作業時不同時間點log theta power
的平均數(標準差)及統計結果……………………..………54
表八 執行運作記憶作業時不同時間點log beta1 power
的平均數(標準差)及統計結果……………………………55

表九 執行警覺性作業時不同時間點的平均反應時間
(標準差)及統計結果(以秒為單位)…………………………..56
表十 執行警覺性作業時不同時間點反應遺漏率
(omission rate)的平均數(標準差)及統計結果…………….…57
表十一 執行警覺性作業時不同時間點反應錯誤率
(commission rate)的平均數(標準差)及統計結果…………....58
表十二 執行警覺性作業時不同時間點的d’ 值(標準差)
及統計結果…………………………………………………….59
表十三 執行警覺性作業時不同時間點log alpha power
的平均數(標準差)及統計結果………………………….…60
表十四 執行警覺性作業時不同時間點log theta power
的平均數(標準差)及統計結果………………………………61
表十五 執行警覺性作業時不同時間點log beta2 power
的平均數(標準差)及統計結果…………………………….62
表十六 執行警覺性作業時不同時間點log beta1 power
的平均數(標準差)及統計結果…………………………….63
表十七 睜眼及閉眼狀況下的前後測Resting EEG 的
log alpha power 平均數(標準差)及統計結果…………….64
表十八 睜眼及閉眼狀況下的前後測Resting EEG 的
log theta power 平均數(標準差)及統計結果…………….65
表十九 睜眼及閉眼狀況下的前後測Resting EEG 的
log beta2 power 平均數(標準差)及統計結果……………66
表二十 睜眼及閉眼狀況下的前後測Resting EEG 的
log beta1 power 平均數(標準差)及統計結果……………67
表二十一 情緒評量表前後測的平均數(標準差)及統計結果……..68


圖目錄

圖一 認知作業施測順序 ………………………………………… 24

圖二 警覺性作業目標刺激及非目標刺激圖…………………….26
參考文獻 Aaronson LS, Teel CS, Cassmeyer V et al. Defining and measuring fatigue. Journal of Nursing Scholarship 1999; 31(1): 45-50.

Aeschbach D, Matthews JR, Postolache T et al. Dynamics of the human EEG during prolonged wakefulness:evidence for frequency-specific circadian and homeostatic influences. Neuroscience Letters 1997; 239: 121-124.

Ahsberg E, Ganberale F, Gustafsson K. Perceived fatigue after mental work:an experimental evaluation of a fatigue inventory. Ergonomics 2000; 43(2): 252-268.

Chapotot F, Jouny C, Muzet A, Buguet A, Brandenberger G. High frequency waking EEG: reflection of a slow ultradian rhythm in daytime arousal. NeuroReport ; 2000; 11(10): 2223 – 2227.

Corsi-Cabrera M, Arce C, Ramos J et al. Time course of reaction time and EEG while performing a vigilance task during total sleep deprivation. Sleep 1996; 19(7):563-569.

Costa L, Arruda JE, Stern RA, Somerville JA. Asymptomatic HIV-infected women:preliminary study of quantitative EEG activity and performance on a continuous performance test. Perceptual and Motor Skills 1997; 85:1395-1408.

Cummings L, Dane A, Rhodes J et al. Diurnal variation in the quantitative EEG in healthy adult volunteers. Journal of Clinical Pharmacology 2000; 50: 21-26.

DeLuca J, Jonhson SK, Ellis SP, Natelson BH. Cognitive functioning is impaired in patients with chronic fatigue syndrome devoid of psychiatric disease. Journal of Neurology , Neurosurgery , and Psychiatry 1997; 62:151-155

DeLuca J, Johnson SK, Beldowicz D, Natelson BH. Neuropsychological impairments in chronic fatigue syndrome, multiple sclerosis, and depression. Journal of Neurology , Neurosurgery , and Psychiatry 1995; 58:38-43.

DeLuca J, Johnson SK, Natelson BH. Information processing efficiency in chronic fatigue syndrome and multiple sclerosis. Archives of Neurology 1993; 50:301-304.

Fukuda K, Straus SE, Hickie I et al. The chronic fatigue syndrome:A comprehensive approach to its definition and study. Annals of Internal Medicine 1994; 121:953-959.

Gasser T, Bacher P, Mocks J. Transformations towards the normal distribution of broad band spectral parameters of the EEG. Electorencephalography and Clinical Neurophysiology 1982; 53: 119- 124.

Gevins A, Smith ME. Detecting transient cognitive impairment with EEG pattern recognition methods. Aviation Space Environmental Medicine 1999; 70: 1018-1024.

Gevins A, Smith ME, McEvoy L, Yu D. High-resolution EEG mapping of cortical activation related to working memory: effects of task difficulty, type of processing, and practice. Cerebral Cortex 1997; 7:374-385.

Gevins A, Smith ME et al. High resolution evoked potential imaging of the cortical dynamics of human working memory. Electroencephalography and Clinical Neurophysiology 1996; 327-348.

Grafman J, Schwartz V, Dale JK, Scheffers M et al. Analysis of neuropsychological functioning in patients with chronic fatigue syndrome. Journal of Neurology , Neurosurgery , and Psychiatry 1993; 56: 684-689.

Gundel A, Wilson GF. Topographical changes in the ongoing EEG related to the difficulty of mental tasks. Brain Topography 1992; 5(1) :17-25.

Holmes GP, Kaplan JE, Gantz NM et al. Chronic fatigue syndrome:A working case definition. Annals of Internal Medicine 1988; 108: 387-389.

Johnson SK, Lange G, DeLuca J, Korn L, Natelson BH. The effects of fatigue on neuropsychological performance in patients with chronic fatigue syndrome, multiple sclerosis, and depression. Applied Neuropsychology 1997; 4(3): 145-153.

Johnson SK, DeLuca J, Fiedler N, Natelson BH. Cognitive functioning in chronic fatigue syndrome. Clinical Infectious Disease 1994; 18 (suppl 1):s84-5.

Kim E. A brief history of chronic fatigue syndrome. JAMA 1994; 272(13): 1070-1071.

Krupp LB, Sliwinski M, Masur DM, Friedberg F et al. Cognitive functioning and depression in patients with chronic fatigue syndrome and multiple sclerosis. Archives of Neurology 1994; 51:705-710.

Makeig S and Jung TP. Changes in alertness are a principal component of variance in the EEG spectrum. NeuroReport 1995; 7:213-216.

Markand ON. Alpha rhythms. Journal of Clinical Neurophysiology 1990; 7(2): 163-189.

Marshall PS, Forstot M, Callies A et al. Cognitive slowing and working memory difficulties in chronic fatigue syndrome. Psychosomatic Medicine 1997; 59:58-66.

Marshall PS, Watson D, Steinberg P, Cornblatt B et al. An assessment of cognitive function and mood in chronic fatigue syndrome. Biological Psychiatry 1996; 39: 199-206.

Matousek M and Peterson I A method for assessing alertness fluctuations from EEG spectra. Electrencephalography and Clinical Neurophysiology 1983; 55: 108-113.

McEvoy LK, Smith ME, Gevins A. Test-retest reliability of cognitive EEG. Clinical Neurophysiology 2000; 111:457-463.

Michiels V, Cluydts R. Neuropsychological functioning in chronic fatigue syndrome: a review Acta Psychiatrica Scandinavica 2001; 103: 84 – 93.

Michiels V, Gucht V, Cluydts R et al. Attention and information processing efficiency in patients with chronic fatigue syndrome. Journal of Clinical and Experimental Neuropsychology 1999; 21(5): 709-729.

Nuwer MR. Quantitative EEG:I. Techniques and problems of frequency analysis and topographic mapping. Journal of Clinical Neurophysiology 1988; 5(1):1-43.

Pivik RT, Broughton RJ, Coppola RJ et al., Guidelines for the recording and quantitative analysis of electroencephalographic activity in research contexts. Psychophysiology 1993; 30: 547-558.

Prasher D, Smith A, Findley L. Sensory and cognitive event related potentials in myalgic encephalomyelitis. Journal of Neurology , Neurosurgery , and Psychiatry 1990;1;253-257.

Scheffers MK, Johnson R, Grafman J, Dale JK, Straus SE. Attention and short-term memory in chronic fatigue syndrome patients:An event-related potential analysis. Neurology 1992; 42:1667-1675.

Sharpe MC, Archard LC, Banatvala JE el al. A report – chronic fatigue syndrome: guidelines for research. Journal of the Royal Society of Medicine 1991; 84: 118 – 121.

Vercoulen JHMM, Bazelmans E et al. Evaluating neuropsychological impairment in chronic fatigue syndrome. Journal of Clinical and Experimental Neuropsychology 1998; 20(2): 144-156.

Wearden A, Appleby L. Cognitive performance and complaints of cognitive impairment in chronic fatigue syndrome (CFS). Psychlogical Medicine 1997; 27: 81-90.

Wilson GF, Fisher F. Cognitive task classification based upon topographic EEG data. Biological psychology 1995; 40: 239-250.
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