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系統識別號 U0026-0402202023392000
論文名稱(中文) 具除法功能之應用於電化學阻抗頻譜量測系統之頻率可調信號處理晶片
論文名稱(英文) Design of a Wide-Range Programmable Frequency Signal Processing IC with a Divider for Electrochemical Impedance Spectroscopy Measurement System
校院名稱 成功大學
系所名稱(中) 電機工程學系
系所名稱(英) Department of Electrical Engineering
學年度 108
學期 1
出版年 109
研究生(中文) 林昊緯
研究生(英文) Hao-Wei Lin
學號 N26060240
學位類別 碩士
語文別 英文
論文頁數 73頁
口試委員 指導教授-魏嘉玲
口試委員-張順志
口試委員-蔡建泓
口試委員-鄭光偉
口試委員-黃崇勛
中文關鍵字 生物晶片  電化學阻抗頻普分析法  可攜式電化學阻抗頻譜量測系統 
英文關鍵字 Biochip  Electrochemical impedance spectroscopy  Automatic EIS measurement system 
學科別分類
中文摘要 隨著高齡化社會的到來,因此老人的居家照護已變成一重要課題。有別於醫療院所使用之高精確大型檢測儀器,輕量化、便於攜帶、快速檢測之居家照顧儀器的市場正在穩定發展,因此將整個系統晶片化是目前的趨勢,以此來達成降低成本和體積的需求。電化學阻抗頻譜分析法(Electrical Impedance Spectroscopy, EIS) 是一項常用的電化學檢測方式,本晶片實現一大頻寬範圍之電化學阻抗頻譜分析晶片,並藉由筆記型電腦、資料截取卡和離散電路組成一完整自動量測系統。
本晶片使用台灣積體電路公司0.35μm 2P4M混合訊號製程製作而成,晶片尺寸約為2.0166×2.4004mm2,以48 S/B封裝,處理信號頻率範圍為100mHz到100kHz,藉由資料截取卡與電腦連接,並由一九伏電池為系統供電,以達成一可攜、即時量測系統。
英文摘要 As many countries have been aging society, home care issue has been more and more important. Different from the high accuracy and expansive instruments used in hospitals, light, real-time, and portable instruments for home care have drown more and more attention. The market of those instruments has grown a lot in recent years. One of the recent trends is to integrate the system into one signal chip to reduce the cost and volume of the system. Electrical Impedance Spectroscopy (EIS) is one of the commonly-used detection methods. The proposed chip could realize a wide-range frequency EIS detection. By connecting the chip with a laptop by data acquisition (DAQ) card, an automatic EIS measurement system could be achieved.
The proposed chip was fabricated by TSMC 0.35μm 2P4M CMOS/MEMS mixed-signal process, and the chip size is 2.0166×2.4004mm2. The frequency range of the chip is from 100mHz to 100kHz. Since the whole PCB is powered by a single 9V-battery, a portable and real-time system could be achieved.
論文目次 Chapter 1 Introduction 1
1.1 Motivation 1
1.2 Organization 1
Chapter 2 Background of Biomedical Detection Technology 2
2.1 Methods of Electrochemical Analysis 3
2.1.1 Cyclic Voltammetry (CV) 3
2.1.2 Chronopotentiometry 5
2.1.3 Electrochemical Impedance Spectroscopy (EIS) 7
2.2 Adopted Architecture of EIS and Previous Version 9
2.2.1 Switched-Capacitor Filter 10
2.2.2 Phase-to-Digital Converter 11
2.2.3 Divider 12
Chapter 3 System Architecture and Circuit Design 13
3.1 Block Diagram 13
3.2 Clock Generator 14
3.3 Reference Circuit 16
3.4 Wide-Range Programmable Frequency Sinewave Generator 17
3.5 Switched-Capacitor Band-Pass Filter 19
3.6 Magnitude Detector 20
3.7 Magnitude Detector and Divider Controller 22
3.8 Divider 24
3.8.1 Voltage to Pulse Generator 25
3.8.2 Pulse Divider 27
3.8.3 Counter 31
3.9 Phase-to-Digital Converter 32
Chapter 4 Design of an EIS System of Printed Circuit Board 33
4.1 PCB Circuit and Design 33
4.1.1 Battery-Powered Supply Circuit 34
4.1.2 Level Shifting and Amplitude Adjustment Circuit 34
4.1.3 Transimpedance Amplifier 34
4.1.4 Filter and Instrumentation Amplifier (IA) 36
4.2 PCB Schematic and Layout 36
4.3 LabVIEW Program and Data Acquisition (DAQ) 38
4.3.1 Control Signal 39
4.3.2 Data Acquiring 41
4.3.3 Data Processing 41
Chapter 5 Simulation Result and Layout 43
5.1 Simulation Result 43
5.1.1 Low-Pass Filter 43
5.1.2 Band-Pass Filter 44
5.1.3 Magnitude Detector 45
5.1.4 Divider 47
5.1.5 Phase-to-Digital Converter 51
5.2 Layout 52
5.3 Bounding Wire Diagram 53
Chapter 6 Measurement Result 54
6.1 Chip Function Measurement 54
6.1.1 Measurement Environment 54
6.1.2 SC Filter 56
6.1.3 Magnitude Detector 58
6.1.4 Divider 60
6.1.5 Phase-to-Digital Converter 64
6.2 System Measurement 65
6.2.1 Measurement Environment 65
6.2.2 Measurement Result 66
6.3 Specification 70
Chapter 7 Conclusion and Future Work 71
References 72
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[5] X. Liu, D. Rairigh, C. Yang, and A. Mason, “Impedance-to-digital Converter for Sensor Array Microsystems,” in Circuits and Systems, 2009. ISCAS 2009. IEEE International Symposium on. IEEE, 2009, pp. 353–356
[6] Yi-Wen Wang, Chia-Ling Wei, “A Wide-Rang Programmable Sinusoidal Frequency Synthesizer for Electrochemical Impedance Spectroscopy Measurement System,” M.S. thesis, Dept. of Elect. Eng., National Cheng Kung Univ., Tainan, Taiwan, R.O.C., Jul., 2012.
[7] Chia-Ning Su, Chia-Ling Wei, “Design of a Wide-Frequency-Range Signal Processing IC for Electrochemical Impedance Spectroscopy Measurement System,” M.S. thesis, Dept. of Elect. Eng., National Cheng Kung Univ., Tainan, Taiwan, R.O.C., Jul., 2016.
[8] Wen-Jui Wu, Chia-Ling Wei, “Design of an Impedance-to-Digital Converter for Electrochemical Impedance Spectroscopic Measurement System,” M.S. thesis, Dept. of Elect. Eng., National Cheng Kung Univ., Tainan, Taiwan, R.O.C., Jun. 2013.
[9] Kuan-Hung Chen, Chia-Ling Wei, “Novel High-Accuracy Low-Power Voltage-Mode Analog Divider with Digital Output” M.S. thesis, Dept. of Elect. Eng., National Cheng Kung Univ., Tainan, Taiwan, R.O.C., Jul , 2018.
[10] Tse-An Chen, Wen-Jui Wu, Chia-Ling Wei, and Bin-Da Liu, “Novel 10-Bit Impedance-to-Digital Converter for Electrochemical Impedance Spectroscopy Measurements,” IEEE Trans. Biomed. Circuits Syst., vol. 11, no. 2, Apr. 2017, pp.370-379.
[11] Siang-Wei Wang, Chia-Ling Wei, “Design of Peak Detector and Divider for Electrochemical Impedance Spectroscopy Measurement System” M.S. thesis, Dept. of Elect. Eng., National Cheng Kung Univ., Tainan, Taiwan, R.O.C., Jan., 2017.
[12] Diodes Incorporated, Inc., (2011), AP1117, Plano, TX. [Online]. Available: https://www.diodes.com/assets/Datasheets/AP1117_R21.pdf
[13] Texas Instruments, Inc., (2008), OPA344, Dallas TX. [Online]. Available: https://www.ti.com/lit/ds/symlink/opa344.pdf
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[15] Metrohm DropSens, Inc., (2008), 250AT, Herisau, Switzerland [Online]. Available: http://www.dropsens.com/pdfs_productos/dropsens_catalogue.pdf
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