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系統識別號 U0026-0208201915042600
論文名稱(中文) 利用半自發製程由雙十二碳鏈離子對雙親分子及添加劑製備液胞結構
論文名稱(英文) Fabrication of vesicular structures from didodecyl-chained ion pair amphiphile with additives by using a semi-spontaneous process
校院名稱 成功大學
系所名稱(中) 化學工程學系
系所名稱(英) Department of Chemical Engineering
學年度 107
學期 2
出版年 108
研究生(中文) 陳學陵
研究生(英文) Samuel Sitorus
學號 N36067074
學位類別 碩士
語文別 英文
論文頁數 122頁
口試委員 指導教授-張鑑祥
口試委員-周宗翰
口試委員-楊毓民
口試委員-賁煜
中文關鍵字 none 
英文關鍵字 Catanionic vesicles  Intra-vesicular approach  Inter-vesicle approach  Semi-spontaneous process  Homogenizing time  Ion Pair Amphiphile 
學科別分類
中文摘要 none
英文摘要 ABSTRACT
In this study, ion pair amphiphile (IPA), dodecyltrimethylammonium-dodecylsulfate (DTMA-DS), composed of anionic surfactant, sodium dodecylsulfate (SDS), and cationic surfactant, dodecyltrimethylammonium bromide (DTMAB), was successfully fabricated. Then, catanionic vesicles were prepared from the IPA by a semispontaneous approach. The effects of added cholesterol and cationic surfactants, dihexadecyldimethylammonium (DHDAB) and ditetradecyldimethylammonium bromide (DTDAB), DTMA-DS/cholesterol vesicles on the physical properties and stability of the catanionic vesicles were evaluated. Without the addition of cationic surfactants, a negative charge character of the vesicle surfaces was detected, in contrast with the addition of cationic surfactants. A fluorescence polarization study was performed to investigate the bilayer packing characteristics of the vesicles.
Physical stability of the catanionic vesicles determined by visual and vesicle size was monitored with time at room temperature. The mean sizes of the vesicles ranged from 156 to 224 nm with narrow distributions. Negatively charged characteristic of the vesicles was confirmed based on the zeta potential values varying from -21 to -37 mV. The zeta potential of the vesicles with added cationic surfactants (DHDAB or DTDAB) varied from 50 to 132 mV. Incorporation of cholesterol and the homogenizing time were found to be crucial in the formation of stable DTMA-DS/DHDAB and DTMA-DS/ DTDAB catanionic vesicles.
DTDAB was found to provide a positively charged characteristic for the catanionic vesicles, which induced the repulsive interaction between vesicles and thus inhibited the fusion or aggregation of the vesicles. The presence of cholesterol in the DTMA-DS/DTDAB bilayers would increase the distance between the charged headgroups and decrease the counterion binding on the bilayer surfaces, which could explain the cholesterol-enhanced charge character of the catanionic vesicles. The addition of ethanol in the DTMA-DS/DTDAB vesicle system did not enhance the stability of the vesicles, probably because the solvophobic effect of the headgroups tend to diminish the vesicular structures. Transmission electron microscopy (TEM) images have confirmed the spherical structures of the vesicles.
Keyword: Catanionic vesicles; Intra-vesicular approach; Inter-vesicular approach;Ion pair amphiphile; Semi-spontaneous process
論文目次 TABLE OF CONTENTS
Page
ABSTRACT i
ACKNOWLEDGEMENT iii
TABLE OF CONTENTS v
LIST OF TABLES vii
LIST OF FIGURES ix
CHAPTER I INTRODUCTION 1
1.1. Background 1
1.2. Research Motivation 6
CHAPTER II LITERATURE REVIEW 8
2.1. Drug Delivery 8
2.1.1 High-Density Charged Surface 9
2.1.2 Reduction of Disulphide Bridges 10
2.1.3 Zeta Potential Changing Methodology 11
2.2 Ion Pair Amphiphile 13
2.3 Formation of Catanionic Vesicles 17
2.4 The Packing Parameter 21
2.5 Additional Charged Surfactant 30
2.6 Effects of Cholesterol 34
2.7 Effect of Ethanol 38
CHAPTER III EXPERIMENTAL 45
3.1. Materials 45
3.2. Equipments 45
3.2.1 Homogenizer 45
3.2.2 Particle Size/ Zeta Potential Analyzer 51
3.2.3 Laser Doppler Electrophoresis Zeta Potential Analyzer 52
3.2.4 Transmission Electron Microscope 53
3.2.5 Multi-Mode Microplate Reader 54
3.3. Methodology 54
3.3.1 Preparation of DTMA-DS 54
3.3.2 Preparation of Catanionic Vesicles 55
3.3.3 Size Distribution of Catanionic Vesicles 56
3.3.4 Zeta Potential of Catanionic Vesicles 56
3.3.5 Transmission Electron Microscope Observation 56
3.3.6 Fluorescence Polarization Measurement 57
CHAPTER 4 RESULTS AND DISCUSSION 62
4.1. Formation Of Catanionic Vesicles 62
4.1.1 Catanionic Vesicles Formed by DTMA-DS 62
4.1.2 Catanionic Vesicles Formed by DTMA-DS/Cholesterol in Buffer Solution 67
4.1.3 FP Analysis Result 81
4.1.4 Temperature Effect Analysis on the Vesicular Structure 84
4.2 Catanionic Vesicles Formed by DTMA-DS/DHDAB /Cholesterol 87
4.2.1 Zeta Potential Result 98
4.2.2 FP Analysis Result 100
4.2.3. Temperature Effect on The Vesicular Structure 102
4.2.4 Effect of Added Ethanol on the Modified Catanionic Vesicles. 104
CHAPTER V SUMMARY 108
REFERENCES 110
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